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Gene expression reveals overlap between normal aging and Alzheimer's disease genes

Avramopoulos, Dimitrios, Szymanski, Megan, Wang, Ruihua, Bassett, Susan·2011·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2010.04.019PMC PMC2945399
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Crossref · 10.1016/j.neurobiolaging.2010.04.019

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  • Intersection of the microglia signature gene list with 46 publicly available data sets for differentially regulated genes in neurodegenerative and behavioral disorders revealed significant enrichment or depletion of microglia signature genes in 28 of the 46 data sets.

    “We then intersected this gene list with 46 publicly available data sets for differentially regulated genes in neurodegenerative and behavioral disorders derived from microarray or RNA-seq analysis of intact tissue (39–53). Two-sided Fisher’s exact tests revealed significant enrichment or depletion of microglia signature genes in 28 of the 46 data sets (Table S3).”

    From An environment-dependent transcriptional network specifies human microglia identity (2017) · cites this paper as [39]

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Cited by

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Authors
Avramopoulos, D., Szymanski, M., Wang, R., & Bassett, S.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2011-12
Volume
32
Issue
12
Pages
2319.e27-2319.e34
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2010.04.019
PMC
PMC2945399
Cited by
40
References
5
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
NIA (RO1AG022099, RO1AG021804)

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