Prevention of age-related changes in hippocampal levels of 5-methylcytidine by caloric restriction
Open accessAbstract
Aberrant DNA methylation patterns have been linked to molecular and cellular alterations in the aging brain. Caloric restriction (CR) and upregulation of antioxidants have been proposed as interventions to prevent or delay age-related brain pathology. Previously, we have shown in large cohorts of aging mice, that age-related increases in DNA methyltransferase 3a (Dnmt3a) immunoreactivity in the mouse hippocampus were attenuated by CR, but not by overexpression of superoxide dismutase 1 (SOD1). Here, we investigated age-related alterations of 5-methylcytidine (5-mC), a marker of DNA methylation levels, in a hippocampal subregion-specific manner. Examination of 5-mC immunoreactivity in 12- and 24-month-old wild type (WT) mice on control diet, mice overexpressing SOD1 on control diet, wild type mice on CR, and SOD1 mice on CR, indicated an age-related increase in 5-mC immunoreactivity in the hippocampal dentate gyrus, CA3, and CA1-2 regions, which was prevented by CR but not by SOD1 overexpression. Moreover, positive correlations between 5-mC and Dnmt3a immunoreactivity were observed in the CA3 and CA1-2. These findings suggest a crucial role for DNA methylation in hippocampal aging and in the mediation of the beneficial effects of CR on aging.
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A calorie-restricted diet prevents age-related epigenetic and cellular changes.
“prevent age-related epigenetic 44–46 and cellular changes 47”
From Resilience in mental health: linking psychological and neurobiological perspectives. (2013) · cites this paper as [44]
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Resilience in mental health: linking psychological and neurobiological perspectives.
Rutten, B. P. F., Hammels, C., Geschwind, N., Menne‐Lothmann, C., Pishva, E., Schruers, K., van den Hove, D., Kenis, G., van Os, J., & Wichers, M. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12095 · Cited by 418 · see citing works
Self-citationThe epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works
Self-citationReconfiguration of DNA methylation in aging
Zampieri, M., Ciccarone, F., Calabrese, R., Franceschi, C., Bürkle, A., & Caiafa, P. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.02.002 · Cited by 254 · see citing works
Revisiting the genomic hypomethylation hypothesis of aging
Unnikrishnan, A., Hadad, N., Masser, D. R., Jackson, J., Freeman, W. M., & Richardson, A. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13533 · Cited by 113 · see citing works
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion
Ansere, V. A., Ali-Mondal, S., Sathiaseelan, R., Garcia, D. N., Isola, J. V. V., Henseb, J. D., Saccon, T. D., Ocañas, S. R., Tooley, K. B., Stout, M. B., et al. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111425 · Cited by 101 · see citing works
Chouliaras, L., L.A. van den Hove, D., Kenis, G., Keitel, S., R. Hof, P., van Os, J., W.M. Steinbusch, H., Schmitz, C., & P.F. Rutten, B. (2012) · Current Alzheimer Research · doi:10.2174/156720512800618035 · Cited by 91 · see citing works
Self-citation
- Authors
- Chouliaras, L., van den Hove, D. L. A., Kenis, G., Keitel, S., Hof, P. R., van Os, J., Steinbusch, H. W. M., Schmitz, C., & Rutten, B. P. F.
- Affiliations
- Maastricht University Medical Centre (NL)
- Icahn School of Medicine at Mount Sinai (US)
- Anatomische Anstalt (DE)
- Corresponding author
- Rutten, Bart P.F.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 33
- Issue
- 8
- Pages
- 1672-1681
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC3355211
- OpenAlex
- W2068128042
- Cited by
- 78
- References
- 89
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 9 · 2017: 6 · 2016: 2 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 12
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Internationale Stichting Alzheimer Onderzoek (09552, 07551)
- Marie Curie Host Fellowship (MC-EST 020589)
- NIH (P50 AG05138)
- NWO (91106003)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- caloric restriction, DNA methylation, 5-methylcytidine, hippocampus, brain aging, DNMT3A, superoxide dismutase 1, dentate gyrus, CA3, hippocampal subfields
- MeSH terms
- Superoxide Dismutase-1, DNA Methyltransferase 3A, Aging, Animals, Cytidine, Hippocampus, Male, Mice, Inbred C57BL, Mice, Transgenic, Superoxide Dismutase, DNA Methylation, Caloric Restriction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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