The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
The noradrenaline precursor L-DOPS reduces pathology in a mouse model of Alzheimer’s disease
Open accessAbstract
Damage to noradrenergic neurons in the locus coeruleus (LC) is a hallmark of Alzheimer's disease (AD) and may contribute to disease progression. In 5xFAD transgenic mice, which accumulate amyloid burden at early ages, the LC undergoes stress as evidenced by increased astrocyte activation, neuronal hypertrophy, reduced levels of LC-enriched messenger RNAs (mRNAs), and increased inflammatory gene expression. Central nervous system (CNS) noradrenaline (NA) levels in 5-month-old male 5xFAD mice were increased using the NA precursor L-threo-3,4-dihydroxyphenylserine (L-DOPS). After 1 month, L-DOPS treatment improved learning in the Morris water maze test compared with vehicle-treated mice. L-DOPS increased CNS NA levels, and average latency times in the water maze test were inversely correlated to NA levels. L-DOPS reduced astrocyte activation and Thioflavin-S staining; increased mRNA levels of neprilysin and insulin degrading enzyme, and of several neurotrophins; and increased brain-derived neurotrophic factor protein levels. These data demonstrate the presence of LC stress in a robust mouse model of AD, and suggest that raising CNS NA levels could provide benefit in AD.
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“a reduced plaque burden has been shown to be accompanied by a reduced glial activation [6], [60].”
From Galantamine Slows Down Plaque Formation and Behavioral Decline in the 5XFAD Mouse Model of Alzheimer’s Disease (2014) · cites this paper as [60]
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BackgroundMethodThe locus coeruleus and noradrenergic modulation of cognition
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Reboxetine Treatment Reduces Hippocampal Gliosis in the P301S Tauopathy Mouse Model
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Metadata
- Authors
- Kalinin, S., Polak, P. E., Lin, S. X., Sakharkar, A. J., Pandey, S. C., & Feinstein, D. L.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Feinstein, Douglas L.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 33
- Issue
- 8
- Pages
- 1651-1663
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC3646366
- OpenAlex
- W1991513124
- Cited by
- 116
- References
- 59
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 2 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 15 · 2016: 11 · 2015: 4 · 2014: 9 · 2013: 9 · 2012: 5
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Department of Veterans Affairs
- American Alzheimer's Association
- NIH (RO1-AA010005)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, norepinephrine, locus coeruleus, 5xFAD mice, amyloid, astrocyte activation, neuroinflammation, learning disabilities, brain-derived neurotrophic factor, neprilysin, insulin-degrading enzyme, neurotrophins, noradrenergic neurons
- MeSH terms
- Alzheimer Disease, Animals, Antiparkinson Agents, Locus Coeruleus, Male, Mice, Transgenic, Norepinephrine, Droxidopa, Treatment Outcome, Maze Learning, Mice, Adrenergic Neurons
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