Increased working memory-related brain activity in middle-aged women with cognitive complaints
Open accessAbstract
Individuals who report subjective cognitive complaints but perform normally on neuropsychological tests might be at increased risk for pathological cognitive aging. The current study examined the effects of the presence of subjective cognitive complaints on functional brain activity during a working memory task in a sample of middle-aged postmenopausal women. Twenty-three postmenopausal women aged 50-60 completed a cognitive complaint battery of questionnaires. Using 20% of items endorsed as the threshold, 12 women were categorized as cognitive complainers (CC) and 11 were noncomplainers (NC). All subjects then took part in a functional magnetic resonance imaging scanning session during which they completed a visual-verbal N-back test of working memory. Results showed no difference in working memory performance between CC and NC groups. However, the CC group showed greater activation relative to the NC group in a broad network involved in working memory including the middle frontal gyrus (Brodmann area [BA] 9 and 10), the precuneus (BA 7), and the cingulate gyrus (BA 24 and 32). The CC group recruited additional regions of the working memory network compared with the NC group as the working memory load and difficulty of the task increased. This study showed brain activation differences during working memory performance in a middle-aged group of postmenopausal women with subjective cognitive complaints but without objective cognitive deficit. These findings suggest that subjective cognitive complaints in postmenopausal women might be associated with increased cortical activity during effort-demanding cognitive tasks.
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In one study, subjects with subjective cognitive decline showed increased activation in the middle frontal gyrus, precuneus and cingulate gyrus relative to healthy controls during working memory tasks.
“In one study, subjects with SCD showed increased activation in the middle frontal gyrus, the precuneus and the cingulate gyrus relative to HCs during working memory tasks [145].”
From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [145]
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Outcome over seven years of healthy adults with and without subjective cognitive impairment
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Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease
Wang, X., Huang, W., Su, L., Xing, Y., Jessen, F., Sun, Y., Shu, N., & Han, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00395-3 · Cited by 265 · see citing works
Snitz, B. E., Lopez, O. L., McDade, E., Becker, J. T., Cohen, A. D., Price, J. C., Mathis, C. A., & Klunk, W. E. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150113 · Cited by 93 · see citing works
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- Authors
- Dumas, J. A., Kutz, A. M., McDonald, B. C., Naylor, M. R., Pfaff, A. C., Saykin, A. J., & Newhouse, P. A.
- Affiliations
- University of Vermont (US)
- Indiana University Indianapolis (US)
- Corresponding author
- Dumas, Julie A.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 34
- Issue
- 4
- Pages
- 1145-1147
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC3540200
- OpenAlex
- W1985968648
- Cited by
- 61
- References
- 1
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 9 · 2014: 3 · 2013: 2
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- NIA (K01 AG030380, R01 AG021476, R01 AG19771, P30 AG10133, NCRR-00109, DoE SC 0001753, NCI R01 CA101318)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- subjective cognitive complaints, working memory, postmenopausal women, middle-aged women, brain activation, n-back task, precuneus, middle frontal gyrus, cingulate gyrus, cognitive aging, middle frontal cortex
- MeSH terms
- Brain Mapping, Cerebral Cortex, Cognition, Cognition Disorders, Female, Humans, Male, Memory, Short-Term, Middle Aged, Nerve Net, Postmenopause
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