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Cited by 568Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studiesAging and Gerontology Research

Outcome over seven years of healthy adults with and without subjective cognitive impairment

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Reisberg, Barry, Shulman, Melanie B., Torossian, Carol, Leng, Ling, Zhu, Wei·2010·Alzheimer's & Dementia
DOI 10.1016/j.jalz.2009.10.002PMC PMC3873197
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Abstract

Background: Subjective cognitive impairment (SCI) in older persons without manifest symptomatology is a common condition with a largely unclear prognosis. We hypothesized that (1) examining outcome for a sufficient period by using conversion to mild cognitive impairment (MCI) or dementia would clarify SCI prognosis, and (2) with the aforementioned procedures, the prognosis of SCI subjects would differ significantly from that of demographically matched healthy subjects, free of SCI, termed no cognitive impairment (NCI) subjects. Methods: A consecutive series of healthy subjects, aged ≥40 years, presenting with NCI or SCI to a brain aging and dementia research center during a 14‐year interval, were studied and followed up during an 18‐year observation window. The study population (60 NCI, 200 SCI, 60% female) had a mean age of 67.2 ± 9.1 years, was well‐educated (mean, 15.5 ± 2.7 years), and cognitively normal (Mini‐Mental State Examination, 29.1 ± 1.2). Results: A total of 213 subjects (81.9% of the study population) were followed up. Follow‐up occurred during a mean period of 6.8 ± 3.4 years, and subjects had a mean of 2.9 ± 1.6 follow‐up visits. Seven NCI (14.9%) and 90 SCI (54.2%) subjects declined (P < .0001). Of NCI decliners, five declined to MCI and two to probable Alzheimer's disease. Of SCI decliners, 71 declined to MCI and 19 to dementia diagnoses. Controlling for baseline demographic variables and follow‐up time, Weibull proportional hazards model revealed increased decline in SCI subjects (hazard ratio, 4.5; 95% confidence interval, 1.9–10.3), whereas the accelerated failure time model analysis with an underlying Weibull survival function showed that SCI subjects declined more rapidly, at 60% of the rate of NCI subjects (95% confidence interval, 0.45–0.80). Furthermore, mean time to decline was 3.5 years longer for NCI than for SCI subjects (P = .0003). Conclusions: These results indicate that SCI in subjects with normal cognition is a harbinger of further decline in most subjects during a 7‐year mean follow‐up interval. Relevance for community populations should be investigated, and prevention studies in this at‐risk population should be explored.

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  • Individuals with subjective cognitive decline may eventually be diagnosed with mild cognitive impairment, MCI due to Alzheimer's disease, or another form of dementia.

    “Individuals with SCD may eventually be diagnosed with MCI, MCI due to Alzheimer's disease, or another form of dementia.[251][252][253]”

    From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [252]

    The Results (section 3.2; page unavailable) report that participants with subjective cognitive impairment progressed to MCI, probable Alzheimer’s dementia, or dementia associated with other conditions. The Discussion (section 4; page unavailable) suggests that progression to MCI might precede Alzheimer’s dementia, but the study does not report a distinct diagnosis of “MCI due to Alzheimer’s disease.” (LLM, conf=0.84)

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  • Not all those who experience subjective cognitive decline go on to develop MCI or dementia, but many do.

    “Not all those who experience subjective cognitive decline go on to develop MCI or dementia, but many do.”

    From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [278]

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Research works printed but not linked: 2

  1. [5]Reisberg B Gordon B McCarthy M Ferris SH de Leon MJ Stanley B Insight and denial accompanying progressive cognitive decline in normal aging and Alzheimer’s disease Geriatric psychiatry: ethical and legal issues 1985 Washington, DC American Psychiatric Press 37 79
  2. [33]Hsieh HK Savage test Encyclopedia of statistical sciences 1988 Vol 8 New York, NY Wiley 267 270

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Authors
Reisberg, B., Shulman, M. B., Torossian, C., Leng, L., & Zhu, W.
Affiliations
  • New York University (US)
  • Stony Brook University (US)
  • State University of New York (US)
Corresponding author
Reisberg, Barry
ORCID
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2010-01
Volume
6
Issue
1
Pages
11-24
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
DOI
10.1016/j.jalz.2009.10.002
PMC
PMC3873197
OpenAlex
W2107537187
Cited by
568
References
55
Citations by year
2026: 16 · 2025: 23 · 2024: 32 · 2023: 29 · 2022: 36 · 2021: 52 · 2020: 58 · 2019: 53 · 2018: 49 · 2017: 36 · 2016: 42 · 2015: 50 · 2014: 35 · 2013: 23 · 2012: 15
FWCI
12.46
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (P30 AG08051, AG03051, AG09127, AG11505)
  • National Institutes of Health (MH43486)
  • Forest Laboratories
  • National Center for Research Resources (M01 RR00096)
  • Fisher Center for Alzheimer's Research Foundation
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
Keywords
subjective cognitive impairment, mild cognitive impairment
MeSH terms
Age Factors, Aged, Cognition Disorders, Disability Evaluation, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Psychiatric Status Rating Scales, Retrospective Studies, Geriatric Assessment, Disease Progression

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