Beta amyloid deposition maps onto hippocampal and subiculum atrophy in dementia with Lewy bodies
Open accessAbstract
Although dementia with Lewy bodies (DLB) is a synucleinopathy, it is frequently accompanied by beta amyloid (Aβ) accumulation. Elucidating the relationships of Aβ with gray matter atrophy in DLB may yield insights regarding the contributions of comorbid Alzheimer's disease to its disease progression. Twenty healthy controls and 25 DLB subjects underwent clinical assessment, [18 F]-Florbetapir, and 3T magnetic resonance imaging. FreeSurfer was used to estimate cortical thickness and subcortical volumes, and PetSurfer was used to quantify [18 F]-Florbetapir standardized uptake value ratio. Principal component analysis was used to identify the dominant Aβ component for correlations with regional cortical thickness, hippocampal subfields, and subcortical structures. Relative to healthy controls, the DLB group demonstrated increased Aβ in widespread regions encompassing the frontal and temporoparietal cortices, whereas cortical thinning was restricted to the temporal lobe. Among DLB subjects, the Aβ component was significantly associated with more severe hippocampal and subiculum atrophy. These findings may reflect an early process of superimposed AD-like atrophy in DLB, thereby conferring support for the therapeutic potential of anti-Aβ interventions in people with DLB.
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Amyloid PET positivity in LBD may be suggestive of faster neurodegeneration and worse clinical progression compared to negative status.
“Amyloid PET has however been associated with cortical thinning in the hippocampus and greater grey matter loss in the cingulate gyrus and temporal lobe in DLB and this may be suggestive of faster neurodegeneration and worse clinical progression in positive Aβ LBD compared to negative status [46, 174, 176].”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [176]
Amyloid PET has been associated with cortical thinning in the hippocampus and greater grey matter loss in the cingulate gyrus and temporal lobe in DLB.
“Amyloid PET has however been associated with cortical thinning in the hippocampus and greater grey matter loss in the cingulate gyrus and temporal lobe in DLB and this may be suggestive of faster neurodegeneration and worse clinical progression in positive Aβ LBD compared to negative status [46, 174, 176].”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [176]
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Self-citationMak, E., Gabel, S., Su, L., Williams, G. B., Arnold, R., Passamonti, L., Vazquez Rodríguez, P., Surendranathan, A., Bevan-Jones, W. R., Rowe, J. B., et al. (2017) · International Psychogeriatrics · doi:10.1017/s1041610216002143 · Cited by 66 · see citing works
Self-citationMak, E., Su, L., Williams, G. B., Watson, R., Firbank, M., Blamire, A. M., & O'Brien, J. T. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.01.017 · Cited by 51 · see citing works
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The use of neuroimaging techniques in the early and differential diagnosis of dementia
Chouliaras, L., & O’Brien, J. T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02215-8 · Cited by 186 · see citing works
“…has however been associated with cortical thinning in the hippocampus and greater grey matter loss in the cingulate gyrus and temporal lobe in DLB and this may be suggestive of faster neurodegeneration and worse clinical progression in positive A β LBD compared to negative status [46, 174, 176].”
ResultSelf-citation
- Authors
- Mak, E., Donaghy, P. C., McKiernan, E., Firbank, M. J., Lloyd, J., Petrides, G. S., Thomas, A. J., & O'Brien, J. T.
- Affiliations
- University of Cambridge (GB)
- Newcastle University (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Corresponding author
- O'Brien, John T.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 73
- Pages
- 74-81
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2889855813
- Cited by
- 29
- References
- 9
- Citations by year
- 2025: 4 · 2024: 9 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Eli Lilly and Company
- National Institute for Health and Care Research (CL-2016-01-007, ACF-2015-01-010)
- NIHR Newcastle Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- dementia with Lewy bodies, amyloid-beta deposition, hippocampal atrophy, cortical thinning, Alzheimer's disease comorbidity, 18F-florbetapir PET, gray matter atrophy, anti-amyloid therapy, synucleinopathies
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Amyloid beta-Peptides, Disease Progression, Lewy Body Disease, Positron-Emission Tomography
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