Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies
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BACKGROUND: Volumetric atrophy and microstructural alterations in diffusion tensor imaging (DTI) measures of the hippocampus have been reported in people with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, no study to date has jointly investigated concomitant microstructural and volumetric changes of the hippocampus in dementia with Lewy bodies (DLB). METHODS: A total of 84 subjects (23 MCI, 17 DLB, 14 AD, and 30 healthy controls) were recruited for a multi-modal imaging (3T MRI and DTI) study that included neuropsychological evaluation. Freesurfer was used to segment the total hippocampus and delineate its subfields. The hippocampal segmentations were co-registered to the mean diffusivity (MD) and fractional anisotropy (FA) maps obtained from the DTI images. RESULTS: Both AD and MCI groups showed significantly smaller hippocampal volumes compared to DLB and controls, predominantly in the CA1 and subiculum subfields. Compared to controls, hippocampal MD was elevated in AD, but not in MCI. DLB was characterized by both volumetric and microstructural preservation of the hippocampus. In MCI, higher hippocampal MD was associated with greater atrophy of the hippocampus and CA1 region. Hippocampal volume was a stronger predictor of memory scores compared to MD within the MCI group. CONCLUSIONS: Through a multi-modal integration, we report novel evidence that the hippocampus in DLB is characterized by both macrostructural and microstructural preservation. Contrary to recent suggestions, our findings do not support the view that DTI measurements of the hippocampus are superior to volumetric changes in characterizing group differences, particularly between MCI and controls.
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EC and hippocampus are two key vulnerable brain regions in AD, becoming affected in the early stages of AD.
“The EC and hippocampus are two key vulnerable brain regions in AD, becoming affected in the early stages of AD (Mak et al., 2017, Hett et al., 2019).”
From Disrupted structural connectivity in ArcAβ mouse model of Aβ amyloidosis (2020) · cites this paper as Mak et al., 2017
The Results and Discussion report hippocampal atrophy in both AD and MCI, and the Discussion says tau accumulates early in the hippocampus. The Discussion mentions the entorhinal cortex only as connected to hippocampal CA1; it does not say that the entorhinal cortex is affected early in AD. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Self-citationEffect of Gender on Development of Hippocampal Subregions From Childhood to Adulthood
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Hippocampus diffusivity abnormalities in classical trigeminal neuralgia
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“The EC and hippocampus are two key vulnerable brain regions in AD, becoming affected in the early stages of AD (Mak et al., 2017, Hett et al., 2019).”
BackgroundUsing Electroencephalography in Dementia Practice From Diagnostic to Clinical Outcomes
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3D Visualization of the Human Hippocampus Using a Different Imaging Technique
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- Authors
- Mak, E., Gabel, S., Su, L., Williams, G. B., Arnold, R., Passamonti, L., Vazquez Rodríguez, P., Surendranathan, A., Bevan-Jones, W. R., Rowe, J. B., & O'Brien, J. T.
- Affiliations
- University of Cambridge (GB)
- MRC Cognition and Brain Sciences Unit (GB)
- Corresponding author
- Mak, Elijah
- ORCID
- Venue
- International Psychogeriatrics
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 29
- Issue
- 4
- Pages
- 545-555
- ISSN
- 1041-6102 (ISSN-L)
- PMC
- PMC5819731
- OpenAlex
- W2573011376
- Cited by
- 66
- References
- 40
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 10 · 2021: 4 · 2020: 12 · 2019: 10 · 2018: 8 · 2017: 2
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Psychogeriatrics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo (cc-by)
- Funders
- Wellcome Trust (103838)
- NIHR Cambridge Biomedical Research Centre
- PSP Association
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- hippocampus, mild cognitive impairment, Alzheimer's disease, dementia with Lewy bodies, hippocampal subfields, hippocampal atrophy, mean diffusivity, fractional anisotropy, hippocampal volume, CA1, subiculum, memory performance, multimodal MRI
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Female, United Kingdom, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Regression Analysis, Multivariate Analysis, Case-Control Studies, Lewy Body Disease, Diffusion Tensor Imaging, Cognitive Dysfunction
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