The relationship between domain-specific subjective cognitive decline and Alzheimer's pathology in normal elderly adults
Open accessAbstract
We evaluated the associations of subjective (self-reported everyday cognition [ECog]) and objective cognitive measures with regional amyloid-β (Aβ) and tau accumulation in 86 clinically normal elderly subjects from the Alzheimer's Disease Neuroimaging Initiative. Regression analyses were conducted to identify whether individual ECog domains (Memory, Language, Organization, Planning, Visuospatial, and Divided Attention) were equally or differentially associated with regional [18 F]florbetapir and [18 F]flortaucipir uptake and how these associations compared to those obtained with objective cognitive measures. A texture analysis, the weighted 2-point correlation, was used as an additional approach for estimating the whole-brain tau burden without positron emission tomography intensity normalization. Although the strongest models for ECog domains included either tau (planning and visuospatial) or Aβ (memory and organization), the strongest models for all objective measures included Aβ. In Aβ-negative participants, the strongest models for all ECog domains of executive functioning included tau. Our results indicate differential associations of individual subjective cognitive domains with Aβ and tau in clinically normal adults. Detailed characterization of ECog may render a valuable prescreening tool for pathological prediction.
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Amyloid and tau pathologies may give rise to different subjective cognitive domains.
“Specifically, amyloid and tau pathologies may give rise to different subjective cognitive domains [191].”
From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [191]
Both tau protein and amyloid pathology contribute to the manifestation of subjective cognitive decline.
“Studies using amyloid PET and tau PET have coincidentally suggested that both tau protein and amyloid pathology contributed to the manifestation of SCD [190, 191].”
From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [191]
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Sorted by citations
Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease
Wang, X., Huang, W., Su, L., Xing, Y., Jessen, F., Sun, Y., Shu, N., & Han, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00395-3 · Cited by 265 · see citing works
- Authors
- Shokouhi, S., Conley, A. C., Baker, S. L., Albert, K., Kang, H., Gwirtsman, H. E., & Newhouse, P. A.
- Affiliations
- Vanderbilt University Medical Center (US)
- Lawrence Berkeley National Laboratory (US)
- VA Tennessee Valley Healthcare System (US)
- Corresponding author
- Shokouhi, Sepideh
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 81
- Pages
- 22-29
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC6732237
- OpenAlex
- W2946714776
- Cited by
- 31
- References
- 4
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 4
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurobiology of Aging (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- subjective cognitive decline, Alzheimer's disease, amyloid-beta, tau protein, everyday cognition, 18F-florbetapir, 18F-flortaucipir, texture analysis, executive function, memory, visuospatial cognition, divided attention
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Aniline Compounds, Brain, Cognition, Ethylene Glycols, Fluorine Radioisotopes, Humans, Amyloid beta-Peptides, tau Proteins, Radiopharmaceuticals, Positron-Emission Tomography, Neuroimaging, Cognitive Dysfunction
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