White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia
Open accessAbstract
White matter hyperintensities (WMHs) are commonly assumed to represent non-specific cerebrovascular disease comorbid to neurodegenerative processes, rather than playing a synergistic role. We compared the impact of WMHs on grey matter (GM) atrophy and cognition in normal aging (n = 571), mild cognitive impairment (MCI, n = 551), Alzheimer's dementia (AD, n = 212), fronto-temporal dementia (FTD, n = 125), and Parkinson's disease (PD, n = 271). Longitudinal data were obtained from ADNI, FTLDNI, and PPMI datasets. Mixed-effects models were used to compare WMHs and GM atrophy between patients and controls and assess the impact of WMHs on GM atrophy and cognition. MCI, AD, and FTD patients had significantly higher WMH loads than controls. WMHs were related to GM atrophy in insular and parieto-occipital regions in MCI/AD, and frontal regions and basal ganglia in FTD. In addition, WMHs contributed to more severe cognitive deficits in AD and FTD compared to controls, whereas their impact in MCI and PD was not significantly different from controls. These results suggest potential synergistic effects between WMHs and proteinopathies in the neurodegenerative process in MCI, AD and FTD.
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WMH were associated with more severe cognitive deficits in AD and FTD but had no impact in MCI and PD.
“WMH were associated with more severe cognitive deficits in AD and FTD but had no impact in MCI and PD.”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [30]
There is a significant association between WMH, grey matter atrophy and cognitive decline in AD and FTD.
“Nevertheless, there is a significant association between WMH, grey matter atrophy and cognitive decline in AD and FTD.”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [30]
WMH were related to grey matter atrophy in insular and parieto-occipital regions in MCI/AD and frontal regions and basal ganglia in FTD.
“WMH were related to grey matter atrophy in insular and parieto-occipital regions in MCI/AD and frontal regions and basal ganglia in FTD.”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [30]
Dadar et al. found significantly higher WMH loads in MCI, AD and FTD compared to controls.
“They found significantly higher WMH loads in MCI, AD and FTD compared to controls.”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [30]
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MRI data-driven algorithm for the diagnosis of behavioural variant frontotemporal dementia
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The use of neuroimaging techniques in the early and differential diagnosis of dementia
Chouliaras, L., & O’Brien, J. T. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02215-8 · Cited by 186 · see citing works
“…in AD and FTD. Dadar et al. compared 571 normal aging subjects with 551 MCI, 212 AD, 125 FTD and 271 PD from the Alzheimer ’ s disease neuroimaging initiative (ADNI), the frontotemporal lobe degeneration neuroimaging initiative and the Parkinson ’ s Progression Markers Initiative datasets [30].”
BackgroundWhite matter hyperintensities in Alzheimer's disease: Beyond vascular contribution
Garnier‐Crussard, A., Cotton, F., Krolak‐Salmon, P., & Chételat, G. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13057 · Cited by 139 · see citing works
- Authors
- Dadar, M., Manera, A. L., Ducharme, S., & Collins, D. L.
- Affiliations
- Montreal Neurological Institute and Hospital (CA)
- Corresponding author
- Dadar, Mahsa
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 111
- Pages
- 54-63
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W4200317098
- Cited by
- 78
- References
- 8
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 18 · 2023: 17 · 2022: 5
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@McGill (McGill) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (5u01ag024904-10)
- Canadian Institutes of Health Research
- National Institute on Aging (U01-AG-024904, R01AG032306)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- white matter hyperintensities, gray matter atrophy, cognitive decline, Alzheimer's disease, frontotemporal dementia, mild cognitive impairment, Parkinson's disease, cerebrovascular disease, proteinopathies, insula, basal ganglia, parieto-occipital cortex, frontal cortex, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cognition, Female, Humans, Male, Middle Aged, Parkinson Disease, Diffusion Tensor Imaging, Frontotemporal Dementia, Cognitive Dysfunction, White Matter, Gray Matter
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