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Cited by 295Advanced Neuroimaging Techniques and ApplicationsHemispheric Asymmetry in NeuroscienceSchizophrenia research and treatment

White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study.

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Park, Hae-Jeong, Westin, Carl-Fredrik, Kubicki, Marek, Maier, Stephan E., Niznikiewicz, Margaret, Baer, Aaron, Frumin, Melissa, Kikinis, Ron +3 more·2004·NeuroImage
DOI 10.1016/j.neuroimage.2004.04.036PMC PMC2794419
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Abstract

Hemisphere asymmetry was explored in normal healthy subjects and in patients with schizophrenia using a novel voxel-based tensor analysis applied to fractional anisotropy (FA) of the diffusion tensor. Our voxel-based approach, which requires precise spatial normalization to remove the misalignment of fiber tracts, includes generating a symmetrical group average template of the diffusion tensor by applying nonlinear elastic warping of the demons algorithm. We then normalized all 32 diffusion tensor MRIs from healthy subjects and 23 from schizophrenic subjects to the symmetrical average template. For each brain, six channels of tensor component images and one T2-weighted image were used for registration to match tensor orientation and shape between images. A statistical evaluation of white matter asymmetry was then conducted on the normalized FA images and their flipped images. In controls, we found left-higher-than-right anisotropic asymmetry in the anterior part of the corpus callosum, cingulum bundle, the optic radiation, and the superior cerebellar peduncle, and right-higher-than-left anisotropic asymmetry in the anterior limb of the internal capsule and the anterior limb's prefrontal regions, in the uncinate fasciculus, and in the superior longitudinal fasciculus. In patients, the asymmetry was lower, although still present, in the cingulum bundle and the anterior corpus callosum, and not found in the anterior limb of the internal capsule, the uncinate fasciculus, and the superior cerebellar peduncle compared to healthy subjects. These findings of anisotropic asymmetry pattern differences between healthy controls and patients with schizophrenia are likely related to neurodevelopmental abnormalities in schizophrenia.

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  • Hemispheric asymmetry in the UF has been observed for both volume and diffusion metrics, but there are inconsistencies in the directionality of such asymmetry.

    “Hemispheric asymmetry in the UF has been observed for both volume and diffusion metrics but there are inconsistencies in the directionality of such asymmetry of the UF.”

    From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Park et al., 2004

    The Discussion (page unavailable) reports differing left–right patterns of uncinate fasciculus fractional anisotropy and concludes that its asymmetry remains controversial. It also cites a postmortem finding for cross-sectional area and fiber number, but does not report an uncinate fasciculus volume measurement; that specific part of the claim is not established by our copy. (LLM, conf=0.85)

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References 72 · Cited by 295

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Authors
Park, H.-J., Westin, C.-F., Kubicki, M., Maier, S. E., Niznikiewicz, M., Baer, A., Frumin, M., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Corresponding author
Shenton, Martha E.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2004-09
Volume
23
Issue
1
Pages
213-223
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2004.04.036
PMC
PMC2794419
OpenAlex
W2162632094
Cited by
295
References
72
Citations by year
2026: 2 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 12 · 2018: 17 · 2017: 14 · 2016: 11 · 2015: 14 · 2014: 10 · 2013: 9 · 2012: 19
FWCI
15.92
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • Korea Science and Engineering Foundation
  • National Institutes of Health (K02 MH 01110, R01 MH 40799, R01 MH 50747, R01 NS 39335, RO3 MH068464-01)
  • National Center for Research Resources (11747, P41-RR13218)
  • U.S. Department of Veterans Affairs
  • National Alliance for Research on Schizophrenia and Depression
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
schizophrenia, hemispheric lateralization, white matter, fractional anisotropy, corpus callosum, cingulum, optic radiation, superior cerebellar peduncle, internal capsule, uncinate fasciculus, superior longitudinal fasciculus, Demons algorithm, spatial normalization, neurodevelopmental abnormalities
MeSH terms
Adult, Algorithms, Brain, Cerebellum, Corpus Callosum, Dominance, Cerebral, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Nerve Fibers, Optic Nerve, Reference Values, Schizophrenia, Artifacts, Anisotropy, Prefrontal Cortex, Perforant Pathway, Internal Capsule, Diffusion Magnetic Resonance Imaging

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