CoChat
Sign Up
Cited by 376Schizophrenia research and treatmentAdvanced Neuroimaging Techniques and ApplicationsMental Health and Psychiatry

Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study

Open access
Kubicki, Marek, Westin, Carl-Fredrik, Nestor, Paul G, Wible, Cynthia G, Frumin, Melissa, Maier, Stephan E, Kikinis, Ron, Jolesz, Ferenc A +2 more·2003·Biological Psychiatry
DOI 10.1016/s0006-3223(03)00419-0PMC PMC2806222
Open this paper in CoChat — free account

Abstract

Evidence suggests that a disruption in limbic system network integrity and, in particular, the cingulate gyrus (CG), may play a role in the pathophysiology of schizophrenia; however, the cingulum bundle (CB), the white matter tract furnishing both input and output to CG, and the most prominent white matter fiber tract in the limbic system, has not been evaluated in schizophrenia using the new technology of diffusion tensor imaging (DTI). We used line scan DTI to evaluate diffusion in the CB in 16 male schizophrenia patients and 18 male control subjects, group-matched for age, parental socioeconomic status, and handedness. We acquired 4-mm-thick coronal slices through the entire brain. Maps of fractional anisotropy (FA) were generated to quantify diffusion within the left and right CB on eight slices that included the central portion of the CB. Results showed group differences, bilaterally, in area and mean FA for CB, where patients showed smaller area and less anisotropy than controls. For patients, decreased left CB correlated significantly with attention and working memory measures as assessed by the Wisconsin Card Sorting Test. These data provide strong evidence for CB disruptions in schizophrenia, which may be related to disease-related attention and working memory abnormalities.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0006-3223(03)00419-0

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In schizophrenia, primary sensorimotor fasciculi appear comparatively unaffected, while structural abnormalities are consistently reported in frontal fasciculi connecting the frontal lobe with the rest of the brain, including the uncinate, arcuate, superior longitudinal, and cingulum bundle.

    “Specifically, while the primary sensorimotor fasciculi appear to be comparatively unaffected in patients in schizophrenia, structural abnormalities have consistently been reported in the fasciculi connecting the frontal lobe with the rest of the brain, such as the uncinate fasciculus, 25,26 arcuate fasciculus, 27,28 superior longitudinal fasciculus, 29,30 and cingulum bundle.31,32”

    From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [29]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV-TR Axis I Disorders. New York: Biometrics Research Department, New York State Psychiatric Institute; 2001. pp. 67–71. Research Version, Nonpatient Edition. [Google Scholar]
  2. Wilkinson GS. Wide Achievement Test. 3. Wilmington, DE: Wide Range Inc; 1993. [Google Scholar]

Cited by

Sorted by citations

Related

Authors
Kubicki, M., Westin, C.-F., Nestor, P. G., Wible, C. G., Frumin, M., Maier, S. E., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Corresponding author
Shenton, Martha E
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2003-12
Volume
54
Issue
11
Pages
1171-1180
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(03)00419-0
PMC
PMC2806222
OpenAlex
W2088060544
Cited by
376
References
72
Citations by year
2026: 1 · 2025: 6 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 8 · 2018: 4 · 2017: 10 · 2016: 16 · 2015: 17 · 2014: 12 · 2013: 18 · 2012: 15
FWCI
13.10
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • U.S. Public Health Service (P41 1321, 11747)
  • National Institute of Mental Health (R01 MH40799, K02MH001110, R01MH050740, R01MH040799, R01MH 50747, K02MH 01110)
  • National Institute of Neurological Disorders and Stroke (R01NS039335, R01 NS 39335)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
schizophrenia, cingulum, white matter integrity, fractional anisotropy, limbic system, cingulate gyrus, attention, working memory, Wisconsin Card Sorting Test
MeSH terms
Adult, Brain Mapping, Chronic Disease, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Schizophrenia, Anisotropy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review