The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Inhibition and generation of saccades: Rapid event-related fMRI of prosaccades, antisaccades, and nogo trials
Abstract
Flexible, adaptive behavior often requires the inhibition of automatic responses in favor of voluntary response generation. The antisaccade task requires active inhibition of the automatic saccade to a peripheral stimulus followed by generation of a voluntary antisaccade to the opposite location. Previous studies demonstrated greater functional magnetic resonance imaging (fMRI) activation for antisaccades than prosaccades in cortical saccade areas but did not distinguish the relative contributions of saccadic inhibition and generation. To address this question, we compared prosaccades, antisaccades, and nogo trials in a rapid event-related fMRI experiment with ten human subjects (6 female, 4 male). Trials were compound, containing a colored fixation point to cue trial type, followed by a 200-ms gap and then peripheral stimulus presentation and response. Required responses for prosaccade, antisaccade, and nogo trials, respectively, were to generate a saccade to the stimulus, look away from it, and inhibit the automatic saccade while maintaining central fixation. Frontal and supplementary eye fields, anterior cingulate cortex, intraparietal sulcus, and precuneus, exhibited surprisingly similar activation patterns for prosaccade and nogo responses, suggesting that BOLD signal in cortical saccade regions might predominantly reflect visual detection and attention processes rather than saccade generation or inhibition. These regions displayed greater activation for antisaccade responses versus prosaccade or nogo responses, possibly due to visuospatial remapping or increased attention levels in the antisaccade task. In right superior frontal sulcus, right supramarginal gyrus, and posterior cingulate sulcus, activation was greater for nogo compared to prosaccade responses, suggesting a role in active saccadic inhibition.
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“Work in humans and non-human primates have delineated a widely-distributed circuitry that supports AS performance including the frontal, supplementary, and parietal eye fields (FEF, SEF, PEF respectively), as well as prefrontal cortex (PFC) and various subcortical structures such as striatum, thalamus, and cerebellum”
From Developmental changes in brain function underlying the influence of reward processing on inhibitory control (2011) · cites this paper as Brown et al., 2006
In the citing paper
“The brain regions supporting the generation of voluntary saccadic eye movements as well as the processing of rewards are well-delineated”
From Developmental changes in brain function underlying the influence of reward processing on inhibitory control (2011) · cites this paper as Brown et al., 2006
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Immaturities in reward processing and its influence on inhibitory control in adolescence.
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“This is a quantitatively validated approach to estimating components within a trial (Ollinger, Corbetta, and Shulman 2001; Ollinger, Shulman, and Corbetta 2001; Goghari and MacDonald 2008), and it has been previously reported in the literature (Shulman et al. 1999; Corbetta et al. 2000; Wheeler et al. 2005; Brown et a…”
BackgroundMethodInfluentialMcDowell, J. E., Dyckman, K. A., Austin, B. P., & Clementz, B. A. (2008) · Brain and Cognition · doi:10.1016/j.bandc.2008.08.016 · Cited by 417
“…to FEF, increased saccade-related activity in SEF has been observed in a number of functional neuroimaging studies (e.g. Berman et al., 1999; Brown et al., 2006; DeSouza et al., 2003; Dyckman et al., 2007; Gagnon et al., 2002; Kimmig et al., 2001; Matsuda et al., 2004; McDowell et al.,…”
BackgroundResultInfluential
Metadata
- Authors
- Brown, M. R. G., Goltz, H. C., Vilis, T., Ford, K. A., & Everling, S.
- Affiliations
- Western University (CA)
- Corresponding author
- Brown, Matthew R.G.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 33
- Issue
- 2
- Pages
- 644-659
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1990113525
- Cited by
- 143
- References
- 78
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 13 · 2013: 11 · 2012: 8
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- saccades, antisaccade task, prosaccades, saccadic inhibition, oculomotor control, supplementary eye field, anterior cingulate cortex, intraparietal sulcus, precuneus, superior frontal sulcus, supramarginal gyrus, posterior cingulate cortex, attention, BOLD signal
- MeSH terms
- Adult, Brain Mapping, Evoked Potentials, Female, Humans, Kinetics, Magnetic Resonance Imaging, Male, Photic Stimulation, Reaction Time, Reference Values, Saccades
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