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Cited by 123Advanced Neuroimaging Techniques and ApplicationsSchizophrenia research and treatmentFunctional Brain Connectivity Studies

Abnormal brain connectivity in first-episode psychosis: a diffusion MRI tractography study of the corpus callosum

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Price, Gary, Cercignani, Mara, Parker, Geoffrey J.M., Altmann, Daniel R., Barnes, Thomas R.E., Barker, Gareth J., Joyce, Eileen M., Ron, Maria A.·2007·NeuroImage
DOI 10.1016/j.neuroimage.2006.12.019PMC PMC2387200
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Abstract

A model of disconnectivity involving abnormalities in the cortex and connecting white matter pathways may explain the clinical manifestations of schizophrenia. Recently, diffusion imaging tractography has made it possible to study white matter pathways in detail and we present here a study of patients with first-episode psychosis using this technique. We selected the corpus callosum for this study because there is evidence that it is abnormal in schizophrenia. In addition, the topographical organization of its fibers makes it possible to relate focal abnormalities to specific cortical regions. Eighteen patients with first-episode psychosis and 21 healthy subjects took part in the study. A probabilistic tractography algorithm (PICo) was used to study fractional anisotropy (FA). Seed regions were placed in the genu and splenium to track fiber tracts traversing these regions, and a multi-threshold approach to study the probability of connection was used. Multiple linear regressions were used to explore group differences. FA, a measure of tract coherence, was reduced in tracts crossing the genu, and to a lesser degree the splenium, in patients compared with controls. FA was also lower in the genu in females across both groups, but there was no gender-by-group interaction. The FA reduction in patients may be due to aberrant myelination or axonal abnormalities, but the similar tract volumes in the two groups suggest that severe axonal loss is unlikely at this stage of the illness.

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  • Such analyses have been applied to study how white matter fiber tracts are affected in individuals with different disease severity, how tracts relate to cognitive and socio-emotional function, and how tracts develop during human neurodevelopment and aging.

    “Such analyses have been applied to study, e.g., how white matter fiber tracts are affected in individuals with different disease severity (Cha et al., 2015; Chiang et al., 2016; Price et al., 2007), how tracts relate to cognitive and socio-emotional function (Zekelman et al., 2021), and how tracts are developing during human neurodevelopment and aging (Gertheiss et al., 2013; Hasan et al., 2009a;”

    From Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: A review (2022) · cites this paper as Price et al., 2007

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Authors
Price, G., Cercignani, M., Parker, G. J. M., Altmann, D. R., Barnes, T. R. E., Barker, G. J., Joyce, E. M., & Ron, M. A.
Affiliations
  • UCL Queen Square Institute of Neurology (GB)
  • London School of Hygiene & Tropical Medicine (GB)
  • Imperial College London (GB)
  • King's College London (GB)
Corresponding author
Price, Gary
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2007-04
Volume
35
Issue
2
Pages
458-466
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2006.12.019
PMC
PMC2387200
OpenAlex
W2107425325
Cited by
123
References
7
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 12 · 2012: 4
FWCI
7.55
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • Wellcome Trust
  • Multiple Sclerosis Society
  • Engineering and Physical Sciences Research Council (GR/T02669/01)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
first-episode psychosis, schizophrenia, corpus callosum, white matter connectivity, fractional anisotropy, tractography, corpus callosum genu, splenium of corpus callosum, sex differences, myelination, axonal loss
MeSH terms
Adolescent, Adult, Corpus Callosum, Female, Humans, Male, Psychotic Disorders, Schizophrenia, Case-Control Studies, Diffusion Magnetic Resonance Imaging

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