A tensor based morphometry study of longitudinal gray matter contraction in FTD
Open accessAbstract
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by progressive behavioural abnormalities and frontotemporal atrophy. Here we used tensor based morphometry (TBM) to identify regions of longitudinal progression of gray matter atrophy in FTD compared to controls. T1-weighted MRI images were acquired at presentation and 1-year follow-up from 12 patients with mild to moderate FTD and 12 healthy controls. Using TBM as implemented in SPM2, a voxel-wise estimation of regional tissue volume change was derived from the deformation field required to warp a subject's late to early anatomical images. A whole brain analysis was performed, in which a level of significance of p<0.05 corrected for multiple comparisons (family wise error-FWE) was accepted. Based on prior studies, a region of interest (ROI) analysis was also performed, including in the search area bilateral medial and orbital frontal regions, anterior cingulate gyrus, insula, amygdala and hippocampus. Within this ROI a level of significance of p<0.001 uncorrected was accepted. In the whole brain analysis, the anterior cingulate/paracingulate gyri were the only regions that showed significant atrophy change over 1 year. In the ROI analysis, the left ventro-medial frontal cortex, right medial superior frontal gyrus, anterior insulae and left amygdala/hippocampus showed significant longitudinal changes. In conclusion, limbic and paralimbic regions showed detectable gray matter contraction over 1 year in FTD, confirming the susceptibility of these regions to the disease and the consistency with their putative role in causing typical presenting behaviours. These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ROI-based studies identified anterior cingulate, paracingulate, medial temporal, medial frontal and insular regions (1 year) as important for longitudinal change in bvFTD.
“anterior cingulate, paracingulate, medial temporal, medial frontal and insular regions (1 year) (Brambati et al., 2007)”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Brambati et al., 2007
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Development and validation of a geriatric depression screening scale: a preliminary report
Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90033-4 · Cited by 15,025 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688 · see citing works
Maldjian, J., Laurienti, P., Kraft, R., & Burdette, J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,453 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Self-citationCognitive Stimulation in Patients with Dementia: Randomized Controlled Trial
Mapelli, D., Rosa, E. D., Nocita, R., & Sava, D. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353457 · Cited by 3,468 · see citing works
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627 · see citing works
Frackowiak, R. S. J. (1997) · Cited by 1,713 · see citing works
Dynamics of Gray Matter Loss in Alzheimer's Disease
Thompson, P. M., Hayashi, K. M., de Zubicaray, G., Janke, A. L., Rose, S. E., Semple, J., Herman, D., Hong, M. S., Dittmer, S. S., Doddrell, D. M., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00994.2003 · Cited by 1,132 · see citing works
Precentral gyrus discrepancy in electronic versions of the Talairach atlas
Maldjian, J. A., Laurienti, P. J., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.032 · Cited by 868 · see citing works
Patterns of brain atrophy in frontotemporal dementia and semantic dementia
Rosen, H. J., Gorno–Tempini, M. L., Goldman, W. P., Perry, R. J., Schuff, N., Weiner, M., Feiwell, R., Kramer, J. H., & Miller, B. L. (2002) · Neurology · doi:10.1212/wnl.58.2.198 · Cited by 841 · see citing works
Self-citationSurvival in frontotemporal dementia
Hodges, J. R., Davies, R., Xuereb, J. H., Kril, J. J., & Halliday, G. M. (2003) · Neurology · doi:10.1212/01.wnl.0000078928.20107.52 · Cited by 406 · see citing works
Frontotemporal dementia progresses to death faster than Alzheimer disease
Roberson, E. D., Hesse, J., Rose, K. D., Slama, H., Johnson, J. K., Yaffe, K. S., Forman, M. S., Miller, C. A., Trojanowski, J. Q., Kramer, J. H., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000173837.82820.9f · Cited by 290 · see citing works
Self-citationStaging disease severity in pathologically confirmed cases of frontotemporal dementia
Broe, M., Hodges, J., Schofield, E., Shepherd, C., Kril, J., & Halliday, G. (2003) · Neurology · doi:10.1212/01.wnl.0000052685.09194.39 · Cited by 250 · see citing works
Longitudinal stability of MRI for mapping brain change using tensor-based morphometry
Leow, A., Klunder, A. D., Jack, C., Toga, A., Dale, A., Bernstein, M., Britson, P. J., Gunter, J., Ward, C. P., Whitwell, J., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.013 · Cited by 237 · see citing works
Self-citationRates of global and regional cerebral atrophy in AD and frontotemporal dementia
Chan, D., Fox, N. C., Jenkins, R., Scahill, R. I., Crum, W. R., & Rossor, M. N. (2001) · Neurology · doi:10.1212/wnl.57.10.1756 · Cited by 220 · see citing works
(1998) · PubMed · Cited by 213 · see citing works
Srikanth, S., Nagaraja, A., & Ratnavalli, E. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.04.014 · Cited by 201 · see citing works
(2005) · PubMed · Cited by 191 · see citing works
Kipps, C. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.047993 · Cited by 182 · see citing works
Neural correlates of semantic and behavioural deficits in frontotemporal dementia
Williams, G. B., Nestor, P. J., & Hodges, J. R. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.023 · Cited by 168 · see citing works
Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration
Franceschi, M., Anchisi, D., Pelati, O., Zuffi, M., Matarrese, M., Moresco, R. M., Fazio, F., & Perani, D. (2005) · Annals of Neurology · doi:10.1002/ana.20365 · Cited by 166 · see citing works
(1999) · PubMed · Cited by 142 · see citing works
Frontotemporal dementia as a neural system disease
Boccardi, M., Sabattoli, F., Laakso, M. P., Testa, C., Rossi, R., Beltramello, A., Soininen, H. S., & Frisoni, G. B. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.019 · Cited by 136 · see citing works
Predominant ventromedial frontopolar metabolic impairment in frontotemporal dementia
Salmon, É., Garraux, G., Delbeuck, X., Collette, F., Kalbe, E., Zuendorf, G., Perani, D., Fazio, F., & Herholz, K. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00346-x · Cited by 122 · see citing works
Reproducibility of BOLD-based functional MRI obtained at 4 T
Tegeler, C., Strother, S. C., Anderson, J. R., & Kim, S. (1999) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1999)7:4 · Cited by 121 · see citing works
Garraux, G., Salmon, E., Degueldre, C., Lemaire, C., Laureys, S., & Franck, G. (1999) · NeuroImage · doi:10.1006/nimg.1999.0463 · Cited by 109 · cited 2× · see citing works
“…shown that FTD is associated with atrophy or decreased metabolism in this region compared to controls or other dementias (Ishii et al., 1998; Garraux et al., 1999; Rosen et al., 2002; Varrone et al., 2002; Salmon et al., 2003; Boccardi et al., 2005; Franceschi et al., 2005; Jeong et al.,…”
BackgroundResultLongitudinal Patterns of Regional Change on Volumetric MRI in Frontotemporal Lobar Degeneration
Whitwell, J. L., Anderson, V. M., Scahill, R. I., Rossor, M. N., & Fox, N. C. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000077160 · Cited by 77 · see citing works
Varrone, A., Pappatà, S., Caracò, C., Soricelli, A., Milan, G., Quarantelli, M., Alfano, B., Postiglione, A., & Salvatore, M. (2002) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-0883-5 · Cited by 59 · see citing works
Avants, B., Grossman, M., & Gee, J. C. (2005) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000183083.14939.82 · Cited by 19 · see citing works
Curio (2000) · doi:10.1002/(sici)1097-0193(200004)9:4
Flagged first, then by citations
Research works printed but not linked: 1
- Studholme C, Cardenas V, Schuff N, Rosen H, Miller B, Weiner M. Detecting spacially consistent structural differences in Alzheimer’s and frontotemporal dementia using deformation morphometry. MICCAI. 2001:41–48. [Google Scholar]
Cited by
Sorted by citations
Zhou, J., Greicius, M. D., Gennatas, E. D., Growdon, M. E., Jang, J. Y., Rabinovici, G. D., Kramer, J. H., Weiner, M., Miller, B. L., & Seeley, W. W. (2010) · Brain · doi:10.1093/brain/awq075 · Cited by 1,016 · see citing works
Self-citationFrontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia
Seeley, W. W., Crawford, R., Rascovsky, K., Kramer, J. H., Weiner, M., Miller, B. L., & Gorno-Tempini, M. L. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.38 · Cited by 506 · see citing works
Self-citationOn the right side? A longitudinal study of left- versus right-lateralized semantic dementia
Kumfor, F., Landin-Romero, R., Devenney, E., Hutchings, R., Grasso, R., Hodges, J. R., & Piguet, O. (2016) · Brain · doi:10.1093/brain/awv387 · Cited by 224 · see citing works
White matter damage in frontotemporal lobar degeneration spectrum
Agosta, F., Scola, E., Canu, E., Marcone, A., Magnani, G., Sarro, L., Copetti, M., Caso, F., Cerami, C., Comi, G., et al. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr288 · Cited by 180 · see citing works
Brain network connectivity assessed using graph theory in frontotemporal dementia
Agosta, F., Sala, S., Valsasina, P., Meani, A., Canu, E., Magnani, G., Cappa, S. F., Scola, E., Quatto, P., Horsfield, M. A., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31829a33f8 · Cited by 168 · see citing works
Anterior insula degeneration in frontotemporal dementia
Seeley, W. W. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0263-z · Cited by 162 · see citing works
Self-citationRojas, J. C., Wang, P., Staffaroni, A. M., Heller, C., Cobigo, Y., Wolf, A., Goh, S.-Y. M., Ljubenkov, P. A., Heuer, H. W., Fong, J. C., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000011848 · Cited by 106 · see citing works
Self-citationBrain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year
Knopman, D. S., Jack, C. R., Kramer, J. H., Boeve, B. F., Caselli, R. J., Graff-Radford, N. R., Mendez, M. F., Miller, B. L., & Mercaldo, N. D. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a71236 · Cited by 85 · see citing works
Self-citationLongitudinal structural and metabolic changes in frontotemporal dementia
Bejanin, A., Tammewar, G., Marx, G., Cobigo, Y., Iaccarino, L., Kornak, J., Staffaroni, A. M., Dickerson, B. C., Boeve, B. F., Knopman, D. S., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000009760 · Cited by 70 · see citing works
Self-citationManera, A. L., Dadar, M., Collins, D. L., & Ducharme, S. (2019) · NeuroImage: Clinical · doi:10.1016/j.nicl.2019.102079 · Cited by 65 · see citing works
Predicting functional decline in behavioural variant frontotemporal dementia
Josephs, K. A., Whitwell, J. L., Weigand, S. D., Senjem, M. L., Boeve, B. F., Knopman, D. S., Smith, G. E., Ivnik, R. J., Jack, C. R., & Petersen, R. C. (2011) · Brain · doi:10.1093/brain/awq348 · Cited by 56 · see citing works
FTD spectrum: Neuroimaging across the FTD spectrum
Whitwell, J. L. (2019) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2019.05.009 · Cited by 53 · see citing works
Frings, L., Mader, I., Landwehrmeyer, B. G., Weiller, C., Hüll, M., & Huppertz, H. (2012) · Human Brain Mapping · doi:10.1002/hbm.21304 · Cited by 38 · see citing works
Ranasinghe, K. G., Toller, G., Cobigo, Y., Chiang, K., Callahan, P., Eliazer, C., Kramer, J. H., Rosen, H. J., Miller, B. L., & Rankin, K. P. (2021) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12183 · Cited by 13 · see citing works
Self-citationFieldhouse, J. L. P., van Paassen, D. N., van Engelen, M.-P. E., De Boer, S. C. M., Hartog, W. L., Braak, S., Schoonmade, L. J., Schouws, S. N. T. M., Krudop, W. A., Oudega, M. L., et al. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1382593 · Cited by 8 · see citing works
- Authors
- Brambati, S. M., Renda, N. C., Rankin, K. P., Rosen, H. J., Seeley, W. W., Ashburner, J., Weiner, M. W., Miller, B. L., & Gorno-Tempini, M. L.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- University of California, San Francisco (US)
- Wellcome Trust (GB)
- San Francisco VA Medical Center (US)
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 35
- Issue
- 3
- Pages
- 998-1003
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC2443736
- OpenAlex
- W2045387668
- Cited by
- 89
- References
- 37
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 4
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Larry L. Hillblom Foundation
- John Douglas French Alzheimer's Foundation
- University of California, San Francisco
- National Institute on Aging (P50 AG03006, P01AG017586, P01AG019724)
- National Institute of Neurological Disorders and Stroke (R01NS050915)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- frontotemporal dementia, gray matter atrophy, longitudinal brain atrophy, anterior cingulate cortex, paracingulate gyrus, anterior insula, amygdala, hippocampus, medial frontal cortex, superior frontal gyrus, disease progression
- MeSH terms
- Atrophy, Brain, Dementia, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Neurons, Organ Size, Sensitivity and Specificity, Reproducibility of Results, Echo-Planar Imaging, Imaging, Three-Dimensional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
