The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
In vivo mapping of the human locus coeruleus
Open accessAbstract
The locus coeruleus (LC) is a brainstem structure that has widespread cortical and sub-cortical projections to modulate states of attention. Our understanding of the LC’s role in both normal attention and clinical populations affected by disrupted attention would be advanced by having in vivo functional and structural markers of the human LC. Evidence for LC activation can be difficult to interpret because of uncertainty about whether brainstem activity can be accurately localized to the LC. High resolution T1-turbo spin echo (T1-TSE) magnetic resonance imaging (MRI) (in plane resolution of 0.4 mm × 0.4 mm) was used in this study to characterize the location and distribution probability of the LC across 44 adults ranging in age from 19–79 years. Utilizing a study-specific brainstem template, the individual brainstems were aligned into standard space, while preserving variations in LC signal intensity. Elevated T1-TSE signal was observed in the rostral pons that was strongly correlated with the position and concentration of LC cells previously reported in a study of post-mortem brains (r = .90). The elevated T1-TSE signal was used to produce a probabilistic map of the LC in standard Montreal Neurological Institute (MNI) coordinate space. This map can be used to test hypotheses about the LC in human structural and functional imaging studies. Such efforts will contribute to our understanding of attention systems in normal and clinical populations.
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Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
The reorienting system of the human brain: from environment to theory of mind
Corbetta, M., Patel, G., & Shulman, G. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.017 · Cited by 3,889
ALE meta-analysis: controlling the false discovery rate and performing statistical contrasts
Laird, A. R., Fox, P. M., Price, C. J., Glahn, D. C., Uecker, A. M., Lancaster, J. L., Turkeltaub, P. E., Kochunov, P., & Fox, P. T. (2005) · Human Brain Mapping · doi:10.1002/hbm.20136 · Cited by 868
A direct brainstem–amygdala–cortical ‘alarm’system for subliminal signals of fear.
Liddell, B. J., Brown, K. J., Kemp, A. H., Barton, M. J., Das, P., Peduto, A., Gordon, E., & Williams, L. M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.016 · Cited by 670 · cited 4×
“Twelve studies were found in which 28 coordinates were associated with the LC [7 functional MRI (fMRI) studies (Berman et al., 2008; Liddell et al., 2005; Minzenberg et al., 2008; Raizada and Poldrack, 2007; Sterpenich et al., 2006; Tracy et al., 2000; Vandewalle et al., 2007), 5 positron emission tomography (PET) stu…”
BackgroundInfluentialBOLD responses reflecting dopaminergic signals in the human ventral tegmental area
D'Ardenne, K., McClure, S. M., Nystrom, L. E., & Cohen, J. D. (2008) · Science · doi:10.1126/science.1150605 · Cited by 661
Cytoarchitecture and neural afferents of orbitofrontal cortex in the brain of the monkey
Morecraft, R. J., Geula, C., & Mesulam, M. ‐. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903230304 · Cited by 539
Sasaki, M., Shibata, E., Tohyama, K., Takahashi, J., Otsuka, K., Tsuchiya, K., Takahashi, S., Ehara, S., Terayama, Y., & Sakai, A. (2006) · Neuroreport · doi:10.1097/01.wnr.0000227984.84927.a7 · Cited by 496
Sturm, W. (1999) · Neuropsychologia · doi:10.1016/s0028-3932(98)00141-9 · Cited by 443
Cited by
Orienting and reorienting: the locus coeruleus mediates cognition through arousal
Sara, S. J., & Bouret, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.011 · Cited by 1,056
Pupil diameter covaries with BOLD activity in human locus coeruleus
Murphy, P. R., O'Connell, R. G., O'Sullivan, M., Robertson, I. H., & Balsters, J. H. (2014) · Human Brain Mapping · doi:10.1002/hbm.22466 · Cited by 819
Pupillometry and P3 index the locus coeruleus-noradrenergic arousal function in humans
Murphy, P. R., Robertson, I. H., Balsters, J. H., & O'connell, R. G. (2011) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01226.x · Cited by 519
Optimization of Transcutaneous Vagus Nerve Stimulation Using Functional MRI
Yakunina, N., Kim, S. S., & Nam, E.-C. (2017) · Neuromodulation: Technology at the Neural Interface · doi:10.1111/ner.12541 · Cited by 494
Badran, B. W., Dowdle, L. T., Mithoefer, O. J., LaBate, N. T., Coatsworth, J., Brown, J. C., DeVries, W. H., Austelle, C. W., McTeague, L. M., & George, M. S. (2018) · Brain Stimulation · doi:10.1016/j.brs.2017.12.009 · Cited by 396
Metadata
- Authors
- Keren, N. I., Lozar, C. T., Harris, K. C., Morgan, P. S., & Eckert, M. A.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 47
- Issue
- 4
- Pages
- 1261-1267
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2031583388
- Cited by
- 308
- References
- 8
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- green
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