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Neuroimaging of the Philadelphia Neurodevelopmental Cohort
Open accessAbstract
The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded initiative to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness, and understand how genetics impacts this process. As part of this study, 1445 adolescents ages 8-21 at enrollment underwent multimodal neuroimaging. Here, we highlight the conceptual basis for the effort, the study design, and the measures available in the dataset. We focus on neuroimaging measures obtained, including T1-weighted structural neuroimaging, diffusion tensor imaging, perfusion neuroimaging using arterial spin labeling, functional imaging tasks of working memory and emotion identification, and resting state imaging of functional connectivity. Furthermore, we provide characteristics regarding the final sample acquired. Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development.
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Self-citation
Metadata
- Authors
- Satterthwaite, T. D., Elliott, M. A., Ruparel, K., Loughead, J., Prabhakaran, K., Calkins, M. E., Hopson, R., Jackson, C., Keefe, J., Riley, M., Mentch, F. D., Sleiman, P., Verma, R., Davatzikos, C., Hakonarson, H., Gur, R. C., & Gur, R. E.
- Affiliations
- University of Pennsylvania (US)
- Children's Hospital of Philadelphia (US)
- Philadelphia VA Medical Center (US)
- Corresponding author
- Satterthwaite, Theodore D.
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 86
- Pages
- 544-553
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3947233
- OpenAlex
- W2069088601
- Cited by
- 504
- References
- 64
- Citations by year
- 2026: 21 · 2025: 28 · 2024: 39 · 2023: 50 · 2022: 49 · 2021: 51 · 2020: 49 · 2019: 58 · 2018: 43 · 2017: 44 · 2016: 24 · 2015: 27 · 2014: 19
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Lincoln (University of Nebraska) (submittedVersion)
- Funders
- Brain and Behavior Research Foundation (K08MH79364)
- Children's Hospital of Philadelphia
- National Institute of Mental Health (MH089924, T32 MH019112, MH089983, K23MH098130)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- Philadelphia Neurodevelopmental Cohort, brain development, brain maturation, cognitive development, psychiatric vulnerability, adolescents, T1-weighted structural MRI, diffusion tensor imaging, arterial spin labeling, perfusion imaging, working memory, emotion recognition, resting-state functional connectivity, multimodal neuroimaging, data sharing
- MeSH terms
- Adolescent, Adult, Brain, Child, Cognition, Female, Humans, Research Design, Philadelphia, Cohort Studies, Young Adult, Neuroimaging, Multimodal Imaging
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