The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Association of hearing impairment with brain volume changes in older adults
Open accessAbstract
Hearing impairment in older adults is independently associated in longitudinal studies with accelerated cognitive decline and incident dementia, and in cross-sectional studies, with reduced volumes in the auditory cortex. Whether peripheral hearing impairment is associated with accelerated rates of brain atrophy is unclear. We analyzed brain volume measurements from magnetic resonance brain scans of individuals with normal hearing versus hearing impairment (speech-frequency pure tone average > 25 dB) followed in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging for a mean of 6.4 years after the baseline scan (n = 126, age 56–86 years). Brain volume measurements were performed with semi-automated region-of-interest (ROI) algorithms, and brain volume trajectories were analyzed with mixed-effects regression models adjusted for demographic and cardiovascular factors. We found that individuals with hearing impairment (n = 51) compared to those with normal hearing (n = 75) had accelerated volume declines in whole brain and regional volumes in the right temporal lobe (superior, middle, and inferior temporal gyri, parahippocampus, p < .05). These results were robust to adjustment for multiple confounders and were consistent with voxel-based analyses, which also implicated right greater than left temporal regions. These findings demonstrate that peripheral hearing impairment is independently associated with accelerated brain atrophy in whole brain and regional volumes concentrated in the right temporal lobe. Further studies investigating the mechanistic basis of the observed associations are needed.
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Hearing loss and cognitive decline in older adults
Lin, F. R., Yaffe, K., Xia, J., Xue, Q.-L., Harris, T. B., Purchase-Helzner, E., Satterfield, S., Ayonayon, H. N., Ferrucci, L., Simonsick, E. M., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.1868 · Cited by 4,017
Self-citationMesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072
Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain
Resnick, S. M., Pham, D. L., Kraut, M. A., Zonderman, A. B., & Davatzikos, C. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03295.2003 · Cited by 1,425
Self-citationSensory functioning and intelligence in old age: A strong connection.
Lindenberger, U., & Baltes, P. B. (1994) · Psychology and Aging · doi:10.1037//0882-7974.9.3.339 · Cited by 1,237
Social regulation of gene expression in human leukocytes
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-r189 · Cited by 745
Chételat, G., Landeau, B., Eustache, F., Mézenge, F., Viader, F., de la Sayette, V., Desgranges, B., & Baron, J.-C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.05.015 · Cited by 526
Cole, S. W., Hawkley, L. C., Arevalo, J. M. G., & Cacioppo, J. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014218108 · Cited by 306
Cited by
Loughrey, D. G., Kelly, M. E., Kelley, G. A., Brennan, S., & Lawlor, B. A. (2018) · JAMA Otolaryngology–Head & Neck Surgery · doi:10.1001/jamaoto.2017.2513 · Cited by 961
Olfactory and other sensory impairments in Alzheimer disease
Murphy, C. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0097-5 · Cited by 425
Hearing loss and dementia – who is listening?
Lin, F. R., & Albert, M. (2014) · Aging & Mental Health · doi:10.1080/13607863.2014.915924 · Cited by 377
Self-citationAge-related hearing loss and cognitive decline — The potential mechanisms linking the two
Uchida, Y., Sugiura, S., Nishita, Y., Saji, N., Sone, M., & Ueda, H. (2019) · Auris Nasus Larynx · doi:10.1016/j.anl.2018.08.010 · Cited by 355
Mick, P., Reed, M., & Pichora-Fuller, M. (2015) · Seminars in Hearing · doi:10.1055/s-0035-1555116 · Cited by 138
Metadata
- Authors
- Lin, F. R., Ferrucci, L., An, Y., Goh, J. O., Doshi, J., Metter, E. J., Davatzikos, C., Kraut, M. A., & Resnick, S. M.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 90
- Pages
- 84-92
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2029597341
- Cited by
- 530
- References
- 7
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- green
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