Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: A longitudinal MRI study
Abstract
Capturing the dynamics of gray matter (GM) atrophy in relation to the conversion from mild cognitive impairment (MCI) to clinically probable Alzheimer's disease (AD) would be of considerable interest. In this prospective study we have used a novel longitudinal voxel-based method to map the progression of GM loss in MCI patients over time and compared converters to non-converters. Eighteen amnestic MCI patients were followed-up for a predefined fixed period of 18 months and conversion was judged according to NINCDS-ADRDA criteria for probable AD. Each patient underwent a high-resolution T1-weighted volume MRI scan both at entry in the study and 18 months later. We used an optimal VBM protocol to compare baseline imaging data of converters to those of non-converters. Moreover, to map GM loss from baseline to follow-up assessment, we used a modified voxel-based morphometry (VBM) procedure specially designed for longitudinal studies. At the end of the follow-up period, seven patients had converted to probable AD. Areas of lower baseline GM value in converters mainly included the hippocampus, parahippocampal cortex, and lingual and fusiform gyri. Regions of significant GM loss over the 18-month follow-up period common to both converters and non-converters included the temporal neocortex, parahippocampal cortex, orbitofrontal and inferior parietal areas, and the left thalamus. However, there was significantly greater GM loss in converters relative to non-converters in the hippocampal area, inferior and middle temporal gyrus, posterior cingulate, and precuneus. This accelerated atrophy may result from both neurofibrillary tangles accumulation and parallel pathological processes such as functional alteration in the posterior cingulate. The ability to longitudinally assess GM changes in MCI offers new perspectives to better understand the pathological processes underlying AD and to monitor the effects of treatment on brain structure.
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Thalamic atrophy in MCI and hypometabolism in APOE4 carriers have been observed.
“The role of thalamic structure and function in AD appears complex and perhaps nonlinear, as thalamic atrophy in MCI [48] and hypometabolism in APOE4 carriers [49] have been observed, whereas others have reported increased thalamic volume [50] and hypermetabolism with amyloid pathology [51] among APOE4 carriers.”
From Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status (2024) · cites this paper as [48]
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- Authors
- Chételat, G., Landeau, B., Eustache, F., Mézenge, F., Viader, F., de la Sayette, V., Desgranges, B., & Baron, J.-C.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- University of Cambridge (GB)
- Corresponding author
- Chételat, G.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 27
- Issue
- 4
- Pages
- 934-946
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1970300450
- Cited by
- 526
- References
- 49
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 19 · 2023: 7 · 2022: 16 · 2021: 19 · 2020: 15 · 2019: 17 · 2018: 21 · 2017: 25 · 2016: 28 · 2015: 24 · 2014: 31 · 2013: 31 · 2012: 35
- FWCI
- 18.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Institut de Recherches Servier
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- mild cognitive impairment, conversion to Alzheimer's disease, gray matter atrophy, voxel-based morphometry, hippocampus, parahippocampal cortex, posterior cingulate cortex, precuneus, temporal lobe atrophy, thalamus, neurofibrillary tangles, treatment monitoring
- MeSH terms
- Aged, Alzheimer Disease, Amnesia, Atrophy, Brain, Brain Mapping, Cognition Disorders, Female, Humans, Image Interpretation, Computer-Assisted, Functional Laterality, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Disease Progression
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