Cited by 202Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesAdvanced MRI Techniques and Applications

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

One diffusion acquisition and different white matter models: How does microstructure change in human early development based on WMTI and NODDI?

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Abstract

White matter microstructural changes during the first three years of healthy brain development are characterized using two different models developed for limited clinical diffusion data: White Matter Tract Integrity (WMTI) metrics from Diffusional Kurtosis Imaging (DKI) and Neurite Orientation Dispersion and Density Imaging (NODDI). Both models reveal a non-linear increase in intra-axonal water fraction and in tortuosity of the extra-axonal space as a function of age, in the genu and splenium of the corpus callosum and the posterior limb of the internal capsule. The changes are consistent with expected behavior related to myelination and asynchrony of fiber development. The intra- and extracellular axial diffusivities as estimated with WMTI do not change appreciably in normal brain development. The quantitative differences in parameter estimates between models are examined and explained in the light of each model's assumptions and consequent biases, as highlighted in simulations. Finally, we discuss the feasibility of a model with fewer assumptions.

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Crossref · 10.1016/j.neuroimage.2014.12.009

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Metadata

Authors
Jelescu, I. O., Veraart, J., Adisetiyo, V., Milla, S. S., Novikov, D. S., & Fieremans, E.
Affiliations
NYU Langone Health (US)
Corresponding author
Jelescu, Ileana O.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2015-02
Volume
107
Pages
242-256
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2005552408
Cited by
202
References
45
Citations by year
2026: 2 · 2025: 13 · 2024: 11 · 2023: 13 · 2022: 14 · 2021: 18 · 2020: 27 · 2019: 21 · 2018: 29 · 2017: 27 · 2016: 15 · 2015: 12
FWCI
14.08
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (R01-NS088040, R21-NS081230)
  • Raymond and Beverly Sackler Laboratories for Convergence of Physical, Engineering, and Biomedical Sciences
  • Alzheimer Drug Discovery Foundation
  • Belgian Science Policy Office (P7/11)
  • King Baudouin Foundation
  • Belgian American Educational Foundation
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
white matter microstructure, early brain development, white matter tract integrity, NODDI, diffusion kurtosis imaging, corpus callosum, internal capsule, myelination, axial diffusivity, model bias, parameter estimation
MeSH terms
Aging, Axons, Computer Simulation, Corpus Callosum, Female, Humans, Infant, Infant, Newborn, Male, Models, Neurological, Myelin Sheath, Nerve Fibers, Myelinated, Neurites, Internal Capsule, Diffusion Magnetic Resonance Imaging, White Matter

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