Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain
Abstract
High b value diffusion-weighted images sampled at high angular resolution were analyzed using a composite hindered and restricted model of diffusion (CHARMED). Measurements and simulations of diffusion in white matter using CHARMED provide an unbiased estimate of fiber orientation with consistently smaller angular uncertainty than when calculated using a DTI model or with a dual tensor model for any given signal-to-noise level. Images based on the population fraction of the restricted compartment provide a new contrast mechanism that enhances white matter like DTI. Nevertheless, it is assumed that these images might be more sensitive than DTI to white matter disorders. We also provide here an experimental design and analysis framework to implement CHARMED MRI that is feasible on human clinical scanners.
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The Standard Model framework underlies, or is closely related to, several influential models and approaches, including CHARMED, AxCaliber, NODDI, WMTI, SMT, and related multi-compartment formulations.
“This framework underlies, or is closely related to, several influential models and approaches, including CHARMED, AxCaliber, NODDI, WMTI, SMT, and related multi-compartment formulations (Assaf & Basser, 2005; Assaf et al., 2008; Zhang et al., 2012).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Assaf & Basser, 2005
CHARMED and AxCaliber were influential early attempts to estimate restricted fractions and axon caliber distributions from diffusion data.
“CHARMED and AxCaliber were influential early attempts to estimate restricted fractions and axon caliber distributions from diffusion data (Assaf & Basser, 2005; Assaf et al., 2008).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Assaf & Basser, 2005
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“9 shows the same but for the two-fiber data modeled by a dual tensor (Inglis et al., 2001; Tuch et al., 2002) and CHARMED framework with one hindered and two restricted compartments.”
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40 Years of diffusion MRI in the brain: From history to emerging frontiers
Le Bihan, D. (2026) · Imaging Neuroscience · doi:10.1162/imag.a.1365
“This framework underlies, or is closely related to, several influential models and approaches, including CHARMED, AxCaliber, NODDI, WMTI, SMT, and related multi-compartment formulations ( Assaf & Basser, 2005; Assaf et al., 2008; Zhang et al., 2012).”
- Authors
- Assaf, Y., & Basser, P. J.
- Affiliations
- Tel Aviv University (IL)
- National Institutes of Health (US)
- Corresponding author
- Assaf, Yaniv
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 27
- Issue
- 1
- Pages
- 48-58
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2147927529
- Cited by
- 856
- References
- 3
- Citations by year
- 2026: 25 · 2025: 47 · 2024: 29 · 2023: 43 · 2022: 40 · 2021: 74 · 2020: 58 · 2019: 56 · 2018: 57 · 2017: 71 · 2016: 46 · 2015: 79 · 2014: 45 · 2013: 48 · 2012: 31
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Tel Aviv University
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Keywords
- diffusion-weighted imaging, white matter fiber orientation, high angular resolution diffusion imaging, white matter disease, human brain
- MeSH terms
- Algorithms, Brain, Brain Mapping, Computer Simulation, Corpus Callosum, Humans, Image Interpretation, Computer-Assisted, Nerve Fibers, Models, Statistical, Diffusion Magnetic Resonance Imaging
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