Cited by 283Probiotics and Fermented FoodsGut microbiota and healthNeuroscience and Neuropharmacology Research

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Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate

Janik, Rafal, Thomason, Lynsie A.M., Stanisz, Andrew M., Forsythe, Paul, Bienenstock, John, Stanisz, Greg J.·2016·NeuroImage

DOI 10.1016/j.neuroimage.2015.11.018

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Abstract

The gut microbiome has been shown to regulate the development and functions of the enteric and central nervous systems. Its involvement in the regulation of behavior has attracted particular attention because of its potential translational importance in clinical disorders, however little is known about the pathways involved. We previously have demonstrated that administration of Lactobacillus rhamnosus (JB-1) to healthy male BALB/c mice, promotes consistent changes in GABA-A and -B receptor sub-types in specific brain regions, accompanied by reductions in anxiety and depression-related behaviors. In the present study, using magnetic resonance spectroscopy (MRS), we quantitatively assessed two clinically validated biomarkers of brain activity and function, glutamate+glutamine (Glx) and total N-acetyl aspartate+N-acetyl aspartyl glutamic acid (tNAA), as well as GABA, the chief brain inhibitory neurotransmitter. Mice received 1×10(9) cfu of JB-1 per day for 4weeks and were subjected to MRS weekly and again 4weeks after cessation of treatment to ascertain temporal changes in these neurometabolites. Baseline concentrations for Glx, tNAA and GABA were equal to 10.4±0.3mM, 8.7±0.1mM, and 1.2±0.1mM, respectively. Delayed increases were first seen for Glx (~10%) and NAA (~37%) at 2weeks which persisted only to the end of treatment. However, Glx was still elevated 4weeks after treatment had ceased. Significantly elevated GABA (~25%) was only seen at 4weeks. These results suggest specif…

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Authors: Janik, R., Thomason, L. A. M., Stanisz, A. M., Forsythe, P., Bienenstock, J., & Stanisz, G. J.
Affiliations: University of Toronto (CA)
Sunnybrook Research Institute (CA)
St. Joseph’s Healthcare Hamilton (CA)
Medical University of Lublin (PL)
Corresponding author: Stanisz, Greg J.
ORCID: Thomason, Lynsie A.M.
Forsythe, Paul
Bienenstock, John
Stanisz, Greg J.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2016-01
Volume: 125
Pages: 988-995
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2015.11.018
OpenAlex: W2191644128
Cited by: 283
References: 59
Citations by year: 2026: 13 · 2025: 22 · 2024: 40 · 2023: 31 · 2022: 47 · 2021: 35 · 2020: 35 · 2019: 25 · 2018: 12 · 2017: 14 · 2016: 8
FWCI: 15.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
Funders: Giovanni and Concetta Guglietti Family Foundation
McMaster Brain-Body Institute at St. Joseph's Healthcare Hamilton
US Office of Naval Research (N000141410787)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: gut microbiota, oral probiotics, brain GABA, N-acetylaspartate, glutamate, glutamine, neurometabolites, anxiety, depression, GABAA receptor, GABAB receptors, biomarkers
MeSH terms: Gastrointestinal Microbiome, Animals, Aspartic Acid, Brain, Brain Chemistry, Enzyme-Linked Immunosorbent Assay, gamma-Aminobutyric Acid, Magnetic Resonance Imaging, Male, Mice, Inbred BALB C, Magnetic Resonance Spectroscopy, Glutamic Acid, Probiotics, Mice, Lacticaseibacillus rhamnosus

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Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate

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