Cited by 22Tryptophan and brain disordersAdipokines, Inflammation, and Metabolic DiseasesGut microbiota and health

Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities

Open access
Teixeira, Antonio L., Martins, Lais B., Berk, Michael, Bauer, Moisés E.·2022·Clinical Science

Abstract

Individuals with severe psychiatric disorders, such as mood disorders and schizophrenia, are at increased risk of developing other medical conditions, especially cardiovascular and metabolic diseases. These medical conditions are underdiagnosed and undertreated in these patients contributing to their increased morbidity and mortality. The basis for this increased comorbidity is not well understood, possibly reflecting shared risks factors (e.g. lifestyle risk factors), shared biological mechanisms and/or reciprocal interactions. Among overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets.

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Crossref · 10.1042/cs20211106

Cites

240 of 240 references verified0 citation errors · 0 not checkable

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  • Chronic low-grade inflammation is a feature of a variety of physical diseases (e.g., cardiovascular, metabolic and respiratory diseases; cancer, osteoporosis, arthritis) as well as of other serious mental disorders.

    “Chronic low-grade inflammation is also a feature of a variety of physical diseases (e.g., cardiovascular, metabolic and respiratory diseases; cancer, osteoporosis, arthritis) as well as of other serious mental disorders208-211.”

    From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [208]

    The sections ‘Current evidence linking inflammation to the pathophysiology of SMI’ and ‘Inflammation as common denominator to SMI and general medical comorbidities’ (page unavailable) link chronic low-grade inflammation to severe psychiatric disorders and to cardiovascular and metabolic disease. The latter section lists respiratory disease, cancer and osteoporosis as comorbidities, and ‘Association of autoimmune diseases and autoantibodies with SMI’ mentions rheumatoid arthritis, but the copy does not establish chronic low-grade inflammation as a feature of each of those listed conditions. (LLM, conf=0.83)

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1 retracted

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Research works printed but not linked: 1

  1. Beurel, E. and Lowell, J.A. (2018) Th17 cells in depression, pp. 28-34, Academic Press Inc.

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Authors
Teixeira, A. L., Martins, L. B., Berk, M., & Bauer, M. E.
Affiliations
  • 1Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX, U.S.A.
  • Barwon Health (AU)
  • Pontifícia Universidade Católica do Rio Grande do Sul (BR)
Venue
Clinical Science
Published
2022-09
Volume
136
Issue
17
Pages
1257-1280
ISSN
  • 0143-5221 (ISSN-L)
  • 1470-8736
OpenAlex
W4294579021
Cited by
22
References
240
Citations by year
2026: 6 · 2025: 8 · 2024: 6 · 2023: 2
FWCI
1.40
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Clinical Science (publishedVersion)
  • PubMed (publishedVersion)
  • PUCRS Repository (Pontifical Catholic University of Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
  • Figshare (submittedVersion, cc-by)
Funders
  • Wellcome Trust
  • University of Texas Health Science Center at Houston
  • University of Oxford
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • State Government of Victoria
  • Medical Research Council (COVID-19)
  • National Health and Medical Research Council (1156072)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
psychiatric comorbidity, severe mental illness, mood disorders, schizophrenia, cardiovascular disease, metabolic disorders, inflammation, dysbiosis, insulin resistance, cardiometabolic risk, therapeutic target
MeSH terms
Mental Disorders, Humans, Inflammation, Schizophrenia, Comorbidity, Mood Disorders

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