Severe psychiatric disorders and general medical comorbidities: inflammation-related mechanisms and therapeutic opportunities
Open accessAbstract
Individuals with severe psychiatric disorders, such as mood disorders and schizophrenia, are at increased risk of developing other medical conditions, especially cardiovascular and metabolic diseases. These medical conditions are underdiagnosed and undertreated in these patients contributing to their increased morbidity and mortality. The basis for this increased comorbidity is not well understood, possibly reflecting shared risks factors (e.g. lifestyle risk factors), shared biological mechanisms and/or reciprocal interactions. Among overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets.
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Chronic low-grade inflammation is a feature of a variety of physical diseases (e.g., cardiovascular, metabolic and respiratory diseases; cancer, osteoporosis, arthritis) as well as of other serious mental disorders.
“Chronic low-grade inflammation is also a feature of a variety of physical diseases (e.g., cardiovascular, metabolic and respiratory diseases; cancer, osteoporosis, arthritis) as well as of other serious mental disorders208-211.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [208]
The sections ‘Current evidence linking inflammation to the pathophysiology of SMI’ and ‘Inflammation as common denominator to SMI and general medical comorbidities’ (page unavailable) link chronic low-grade inflammation to severe psychiatric disorders and to cardiovascular and metabolic disease. The latter section lists respiratory disease, cancer and osteoporosis as comorbidities, and ‘Association of autoimmune diseases and autoantibodies with SMI’ mentions rheumatoid arthritis, but the copy does not establish chronic low-grade inflammation as a feature of each of those listed conditions. (LLM, conf=0.83)
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Update on bipolar disorder biomarker candidates
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Flagged first, then by citations
Research works printed but not linked: 1
- Beurel, E. and Lowell, J.A. (2018) Th17 cells in depression, pp. 28-34, Academic Press Inc.
Cited by
Sorted by citations
Berk, M., Köhler‐Forsberg, O., Turner, M., Penninx, B. W. J. H., Wrobel, A., Firth, J., Loughman, A., Reavley, N. J., McGrath, J. J., Momen, N. C., et al. (2023) · World Psychiatry · doi:10.1002/wps.21110 · Cited by 336 · see citing works
Self-citation
- Authors
- Teixeira, A. L., Martins, L. B., Berk, M., & Bauer, M. E.
- Affiliations
- 1Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX, U.S.A.
- Barwon Health (AU)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2022-09
- Volume
- 136
- Issue
- 17
- Pages
- 1257-1280
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W4294579021
- Cited by
- 22
- References
- 240
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 6 · 2023: 2
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- Locations
- Clinical Science (publishedVersion)
- PubMed (publishedVersion)
- PUCRS Repository (Pontifical Catholic University of Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Wellcome Trust
- University of Texas Health Science Center at Houston
- University of Oxford
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- State Government of Victoria
- Medical Research Council (COVID-19)
- National Health and Medical Research Council (1156072)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- psychiatric comorbidity, severe mental illness, mood disorders, schizophrenia, cardiovascular disease, metabolic disorders, inflammation, dysbiosis, insulin resistance, cardiometabolic risk, therapeutic target
- MeSH terms
- Mental Disorders, Humans, Inflammation, Schizophrenia, Comorbidity, Mood Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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