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Towards a consensus regarding global signal regression for resting state functional connectivity MRI

Open access
Murphy, Kevin, Fox, Michael D.·2017·NeuroImage

Abstract

The number of resting state functional connectivity MRI studies continues to expand at a rapid rate along with the options for data processing. Of the processing options, few have generated as much controversy as global signal regression and the subsequent observation of negative correlations (anti-correlations). This debate has motivated new processing strategies and advancement in the field, but has also generated significant confusion and contradictory guidelines. In this article, we work towards a consensus regarding global signal regression. We highlight several points of agreement including the fact that there is not a single "right" way to process resting state data that reveals the "true" nature of the brain. Although further work is needed, different processing approaches likely reveal complementary insights about the brain's functional organisation.

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Metadata

Authors
Murphy, K., & Fox, M. D.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2017-07
Volume
154
Pages
169-173
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2557111525
Cited by
1,048
References
62
FWCI
43.49
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Towards a consensus regarding global signal regression for resting state functional connectivity MRI. https://app.cochat.ai/papers/10.1016/j.neuroimage.2016.11.052
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Murphy, K., & Fox, M. D. (2017). Towards a consensus regarding global signal regression for resting state functional connectivity MRI. NeuroImage. https://doi.org/10.1016/j.neuroimage.2016.11.052

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.