Aberrant memory system connectivity and working memory performance in subjective cognitive decline
Open accessAbstract
Subjective cognitive decline, a perceived worsening of cognitive functioning without objective deficit on assessment, could indicate incipient dementia. However, the neural correlates of subjective cognitive decline as assessed by magnetic resonance imaging remain somewhat unclear. Here, we evaluated differences in functional connectivity across memory regions, and cognitive performance, between healthy older adults aged 50 to 85 with (n = 35, Age = 68.5 ± 7.7, 22 female), and without (n = 48, Age = 67.0 ± 8.8, 29 female) subjective cognitive decline. We also evaluated neurite density, fractional anisotropy, and mean diffusivity of the parahippocampal cingulum, cingulate gyrus cingulum, and uncinate fiber bundles in a subsample of participants (n = 37). Participants with subjective cognitive decline displayed lower average functional connectivity across regions of a putative posterior memory system, and lower retrosplenial-precuneus functional connectivity specifically, than those without memory complaints. Furthermore, participants with subjective cognitive decline performed poorer than controls on visual working memory. However, groups did not differ in cingulum or uncinate diffusion measures. Our results show differences in functional connectivity and visual working memory in participants with subjective cognitive decline that could indicate potential incipient dementia.
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Subjects with subjective cognitive decline exhibit higher functional connectivity in the retrosplenial cortex and precuneus and lower functional connectivity in the frontal-parietal cortex and putative posterior memory system.
“Subjects with SCD exhibited higher FC in the retrosplenial cortex and precuneus and lower FC in the frontal-parietal cortex and putative posterior memory system [115, 136, 137].”
From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [115]
In individuals with SCD, significantly decreased FA and increased MD have been observed in the cerebrum, mainly in the hippocampal body, entorhinal cortex and parahippocampal gyrus, uncinated fasciculi, longitudinal fasciculi and corpus callosum, whereas some studies reported no statistically significant differences in diffusion metrics.
“In individuals with SCD, significantly decreased FA and increased MD have been observed in the cerebrum, mainly in the hippocampal body, entorhinal cortex and parahippocampal gyrus, uncinated fasciculi, longitudinal fasciculi and corpus callosum [77, 78, 109–113], whereas Kiuchi et al. and Viviano et al. reported no statistically significant differences in diffusion metrics [114, 115].”
From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [115]
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Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease
Wang, X., Huang, W., Su, L., Xing, Y., Jessen, F., Sun, Y., Shu, N., & Han, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00395-3 · Cited by 265 · see citing works
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- Authors
- Viviano, R. P., Hayes, J. M., Pruitt, P. J., Fernandez, Z. J., van Rooden, S., van der Grond, J., Rombouts, S. A. R. B., & Damoiseaux, J. S.
- Affiliations
- Wayne State University (US)
- Leiden University (NL)
- Corresponding author
- Damoiseaux, Jessica S.
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 185
- Pages
- 556-564
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2896182767
- Cited by
- 77
- References
- 12
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 8 · 2023: 14 · 2022: 9 · 2021: 13 · 2020: 13 · 2019: 6 · 2018: 1
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- NeuroImage (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Netherlands Organisation for Scientific Research (016.136.072)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- subjective cognitive decline, functional connectivity, visual working memory, uncinate fasciculus, white matter microstructure, diffusion MRI, older adults
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Nerve Net, Cognitive Dysfunction
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