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Cited by 187Neurological disorders and treatmentsFunctional Brain Connectivity StudiesTranscranial Magnetic Stimulation Studies

Opportunities of connectomic neuromodulation

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Horn, Andreas, Fox, Michael D.·2020·NeuroImage
DOI 10.1016/j.neuroimage.2020.117180PMC PMC7847552
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Abstract

The process of altering neural activity - neuromodulation - has long been used to treat patients with brain disorders and answer scientific questions. Deep brain stimulation in particular has provided clinical benefit to over 150,000 patients. However, our understanding of how neuromodulation impacts the brain is evolving. Instead of focusing on the local impact at the stimulation site itself, we are considering the remote impact on brain regions connected to the stimulation site. Brain connectivity information derived from advanced magnetic resonance imaging data can be used to identify these connections and better understand clinical and behavioral effects of neuromodulation. In this article, we review studies combining neuromodulation and brain connectomics, highlighting opportunities where this approach may prove particularly valuable. We focus on deep brain stimulation, but show that the same principles can be applied to other forms of neuromodulation, such as transcranial magnetic stimulation and MRI-guided focused ultrasound. We outline future perspectives and provide testable hypotheses for future work.

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Authors
Horn, A., & Fox, M. D.
Affiliations
  • Stiftung Charité (DE)
  • Brigham and Women's Hospital (US)
Corresponding author
  • Horn, Andreas
  • Fox, Michael D.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2020-11
Volume
221
Pages
117180
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2020.117180
PMC
PMC7847552
OpenAlex
W3042297668
Cited by
187
References
146
Citations by year
2026: 25 · 2025: 27 · 2024: 32 · 2023: 33 · 2022: 35 · 2021: 35
FWCI
11.15
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion, other-oa)
  • PubMed Central (acceptedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (AG060987, MH115949, R01 MH113929)
  • Deutsche Forschungsgemeinschaft (410169619, 424778381, TRR 295, 424778381 \u2013 TRR 295)
  • Dystonia Medical Research Foundation
  • G. Harold and Leila Y. Mathers Charitable Foundation
  • Nancy Lurie Marks Family Foundation
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords
neuromodulation, connectomics, deep brain stimulation, brain connectivity, transcranial magnetic stimulation, MR-guided focused ultrasound, brain disorders
MeSH terms
Brain Diseases, Humans, Magnetic Resonance Imaging, Ultrasonic Therapy, Deep Brain Stimulation, Transcranial Magnetic Stimulation, Connectome

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