SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation

Krapivinsky, Grigory, Medina, Igor, Krapivinsky, Luba, Gapon, Svetlana, Clapham, David E·2004·Neuron

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Items 201–287 of 287

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    Djane Braz Duarte, Jian-Hong Duan, G. D. Nicol, Michael R. Vasko, Cynthia M. Hingtgen · 2011 · Journal of Neurophysiology
  2. Molecular organization and assembly of the postsynaptic density of excitatory brain synapses.
    Kim, Eunjoon, Ko, Jaewon · 2006 · Results and Problems in Cell Differentiation
  3. Metabotropic NMDAR Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory
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  6. Extrasynaptic NMDA Receptors Reshape Gene Ranks
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  7. MUPP1 complexes renal K+channels to alter cell surface expression and whole cell currents
    Aleksandra Sinđić, Chunfa Huang, An‐Ping Chen, Yaxian Ding, William A. Miller-Little, Danian Che, Michael F. Romero, Richard Tyler Miller · 2009 · American Journal of Physiology-Renal Physiology
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  12. The MUPP1–SynGAPα protein complex does not mediate activity-induced LTP
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  20. NMDA Receptors
    Ronald S. Petralia, Robert J. Wenthold · 2008 · Humana Press eBooks
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    Abolfazl Rad, Oliver Bartsch, Somayeh Bakhtiari, Changlian Zhu, Yiran Xu, Fabíola Paoli Monteiro, Fernando Kok, Anneke T. Vulto‐van Silfhout, Michael C. Kruer, Michael R. Bowl et al. · 2024 · Clinical Genetics
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    Danai Katsanevaki, SM Till, Ingrid Buller‐Peralta, TC. Watson, MS. Nawaz, Daisy Arkell, S. Tiwari, Vijayakumar Kapgal, Shyam S. Biswal, JAB. Smith et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Forebrain GluN2A overexpression impairs fear extinction and NMDAR-dependent long-term depression in the lateral amygdala
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    Mary B. Kennedy · 2017 · Current Opinion in Neurobiology
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    Lu Chen, Bita Maghsoodi · 2007 · Elsevier eBooks
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    Abdellali Kelil, Stephen W. Michnick · 2019 · Current Opinion in Structural Biology
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    Roger J. Colbran · 2008 · Elsevier eBooks
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    Ben Vermaercke, Ryohei Iwata, Keimpe Weirda, Leïla Boubakar, Paula Rodríguez, Martyna Ditkowska, Vincent Bonin, Pierre Vanderhaeghen · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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    Wan Kong, Shanqing Huang, Zikai Chen, Xiaolin Li, Shujing Liu, Zi Meng Zhang, Ye Yang, Zhanzhang Wang, Xiuqing Zhu, Xiaojia Ni et al. · 2023 · Frontiers in Pharmacology
  45. Scaffold Proteins in the Postsynaptic Density
    Mary B. Kennedy, Edoardo M. Marcora, Holly J. Carlisle · 2008 · Springer eBooks
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    Aliza A. Le, Julie C. Lauterborn, Yousheng Jia, Conor D. Cox, GARY S. LYNCH, Christine M. Gall · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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    Josef T. Kittler, Jonathan G. Hanley, John T. R. Isaac · 2006 · Frontiers in neuroscience
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    Ying‐Hsia Chu, Bin Xu, Purvil Sukhadia, Abhinita S. Mohanty, Sara E. DiNapoli, Alan Loh Ho, Nora Katabi, Snjezana Doğan · 2024 · Head and Neck Pathology
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    Won Hee Jang, Young Joo Jeong, Sun Hee Choi, Won Hee Lee, Mooseong Kim, Sang-Jin Kim, Sang-Hwa Urm, Il Soo Moon, Dae‐Hyun Seog · 2015 · Journal of Life Science
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    A. L. Proskura, Svetlana O. Vechkapova, Татьяна Александровна Запара, A. S. Ratushnyak · 2015 · Russian Journal of Genetics Applied Research
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    Derek Witzig, Het Patel, Ingie Hong, Siddarth Datta Gupta, Richard L. Huganir, Constance L. Smith‐Hicks · 2024 · Springer eBooks
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    Won Hee Jang, Young Joo Jeong, Sun Hee Choi, Sang-Jin Kim, Sang-Hwa Urm, Il Soo Moon, Dae‐Hyun Seog · 2014 · Journal of Life Science
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    Anne Petrie · 2009 · OpenGrey (Institut de l'Information Scientifique et Technique)
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    Dörte Matthäus · 2014
  56. The role of CaMKII binding NMDARs in synaptic plasticity and memory
    Robert Francis Dallapiazza · 2010
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    Daniel D. Marble · 2008 · Deep Blue (University of Michigan)
  58. Voltage-Dependent Regulation of Intracellular Signaling by Ether À go-go K⁺Channels.
    Andrew P. Hegle · 2007 · Deep Blue (University of Michigan)
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    Lauren C. Milner · 2013
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    Won Hee Jang, Young Joo Jeong, Sun Hee Choi, Sung Su Yea, Won Hee Lee, Mooseong Kim, Sang‐Jin Kim, Sang-Hwa Urm, Il Soo Moon, Dae‐Hyun Seog · 2016 · Journal of Life Science
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    Lauren C. Kruse, Kari Johnson Buck · 2016 · Elsevier eBooks
  64. Progresses on autosomal recessive nonsyndromic mental retardation related genes
    Zhangyan Shi, Fuchang Zhang, Xiaocai Gao · 2010 · Hereditas (Beijing)
  65. Characteristics of cellular and synaptic function in rodent forebrain neurons with altered SynGAP expression
    Lindsay A. M. Mizen · 2018 · ERA
  66. Translational regulation of Syngap1 by FMRP modulates NMDAR mediated signalling
    Abhik Paul, Bharti Nawalpuri, Shruthi Sateesh, Ravi Sondekoppa Muddashetty, James Premdoss Clement · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Dual‐Specificity R as/ R ap GTPase Activating Proteins
    Begoña Sot · 2018 · Encyclopedia of Life Sciences
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