Molecular organization and assembly of the postsynaptic density of excitatory brain synapses.

Kim, Eunjoon; Ko, Jaewon

doi:10.1007/400_011

Cited by 11Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeuroinflammation and Neurodegeneration Mechanisms

Molecular organization and assembly of the postsynaptic density of excitatory brain synapses.

Kim, Eunjoon, Ko, Jaewon·2006·Results and Problems in Cell Differentiation

DOI 10.1007/400_011

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Abstract

The postsynaptic density (PSD) is a postsynaptic membrane specialization at excitatory synapses. The PSD is made of macromolecular multiprotein complexes, which contain a variety of synaptic proteins including membrane, scaffolding, and signaling proteins. By coaggregating with postsynaptic cell adhesion molecules, PSD proteins promote the formation and maturation of excitatory synapses. PSD proteins organize signaling pathways to coordinate structural and functional changes in synapses, and they regulate trafficking and recycling of glutamate receptors, which determines synaptic strength and plasticity. Synaptic activity dynamically regulates the assembly of the PSD through mechanisms including protein phosphorylation, palmitoylation, and protein degradation. PSD proteins associate with diverse motor proteins, suggesting that they function as adaptors linking motors to their specific cargoes.

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The PSD dynamically regulates its components through protein phosphorylation, palmitoylation, local protein translation, the ubiquitin-proteasome system for protein degradation, and redistribution of specific proteins (e.g., CaMKIIα, AMPARs) both entering and leaving the PSD.
“The PSD dynamically regulates its components through protein phosphorylation, palmitoylation, local protein translation, the ubiquitin-proteasome system for protein degradation, and redistribution of specific proteins (e.g., CaMKIIα, AMPARs) both entering and leaving the PSD (Kim and Ko, 2006; Sheng and Hoogenraad, 2007).”
From Human Brain/Cloud Interface (2019) · cites this paper as Kim and Ko, 2006

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Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression
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Molecular constituents of the postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography‐tandem mass spectrometry
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Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin
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GRASP-1
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The Rho-Specific GEF Lfc Interacts with Neurabin and Spinophilin to Regulate Dendritic Spine Morphology
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Linkage of the Actin Cytoskeleton to the Postsynaptic Density via Direct Interactions of Abp1 with the ProSAP/Shank Family
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Modular Transport of Postsynaptic Density-95 Clusters and Association with Stable Spine Precursors during Early Development of Cortical Neurons
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The Dynamics of SAP90/PSD-95 Recruitment to New Synaptic Junctions
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Authors: Kim, E., & Ko, J.
Affiliations: Korea Advanced Institute of Science and Technology (KR)
Corresponding author: Kim, Eunjoon
ORCID: Kim, Eunjoon
Ko, Jaewon
Venue: Results and Problems in Cell Differentiation
Publisher: Springer Berlin Heidelberg
Published: 2006-03-23
Volume: 43
Pages: 1-23
DOI: 10.1007/400_011
OpenAlex: W32232486
Cited by: 11
References: 181
Citations by year: 2026: 1 · 2022: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 1
FWCI: 1.50
Type: book chapter
Language: en
Open access: closed
Locations: Springer eBooks (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: postsynaptic density, excitatory synapses, synaptic protein complexes, synaptic scaffolding proteins, synaptic signaling, glutamate receptor trafficking, synaptic plasticity, synapse maturation, protein phosphorylation, palmitoylation, protein degradation, motor proteins
MeSH terms: Animals, Brain, Humans, Models, Biological, Synaptic Transmission, Neuronal Plasticity, Synapses, Dendritic Spines

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Molecular organization and assembly of the postsynaptic density of excitatory brain synapses.

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