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Cited by 1,774Neural and Behavioral Psychology StudiesNeural dynamics and brain functionMemory and Neural Mechanisms

The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.

Uncertainty, Neuromodulation, and Attention

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Yu, Angela J., Dayan, Peter·2005·Neuron
DOI 10.1016/j.neuron.2005.04.026
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Abstract

Uncertainty in various forms plagues our interactions with the environment. In a Bayesian statistical framework, optimal inference and prediction, based on unreliable observations in changing contexts, require the representation and manipulation of different forms of uncertainty. We propose that the neuromodulators acetylcholine and norepinephrine play a major role in the brain's implementation of these uncertainty computations. Acetylcholine signals expected uncertainty, coming from known unreliability of predictive cues within a context. Norepinephrine signals unexpected uncertainty, as when unsignaled context switches produce strongly unexpected observations. These uncertainty signals interact to enable optimal inference and learning in noisy and changeable environments. This formulation is consistent with a wealth of physiological, pharmacological, and behavioral data implicating acetylcholine and norepinephrine in specific aspects of a range of cognitive processes. Moreover, the model suggests a class of attentional cueing tasks that involve both neuromodulators and shows how their interactions may be part-antagonistic, part-synergistic.

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Metadata

Authors
Yu, A. J., & Dayan, P.
Affiliations
Gatsby Computational Neuroscience Unit (GB)
Corresponding author
Yu, Angela J.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2005-05
Volume
46
Issue
4
Pages
681-692
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2005.04.026
OpenAlex
W2154562678
Cited by
1,774
References
97
Citations by year
2026: 111 · 2025: 127 · 2024: 105 · 2023: 115 · 2022: 105 · 2021: 121 · 2020: 118 · 2019: 103 · 2018: 83 · 2017: 91 · 2016: 81 · 2015: 66 · 2014: 108 · 2013: 76 · 2012: 85
FWCI
19.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • TUbilio (Technical University of Darmstadt) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
uncertainty, neuromodulation, acetylcholine, norepinephrine, attention, Bayesian inference, context switching, attentional cueing, prediction, noisy environments, learning
MeSH terms
Acetylcholine, Algorithms, Animals, Attention, Bayes Theorem, Computer Simulation, Dose-Response Relationship, Drug, Generalization, Psychological, Humans, Learning, Models, Neurological, Nicotine, Norepinephrine, Scopolamine, Time Factors, Likelihood Functions, Signal Detection, Psychological, Nicotinic Agonists, Muscarinic Antagonists, Maze Learning, Uncertainty, Rats

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