Cited by 1,774Neural and Behavioral Psychology StudiesNeural dynamics and brain functionMemory and Neural Mechanisms

The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.

Uncertainty, Neuromodulation, and Attention

Open access

Yu, Angela J., Dayan, Peter·2005·Neuron

DOI 10.1016/j.neuron.2005.04.026

Open this paper in CoChat — free account Open PDF

Abstract

Uncertainty in various forms plagues our interactions with the environment. In a Bayesian statistical framework, optimal inference and prediction, based on unreliable observations in changing contexts, require the representation and manipulation of different forms of uncertainty. We propose that the neuromodulators acetylcholine and norepinephrine play a major role in the brain's implementation of these uncertainty computations. Acetylcholine signals expected uncertainty, coming from known unreliability of predictive cues within a context. Norepinephrine signals unexpected uncertainty, as when unsignaled context switches produce strongly unexpected observations. These uncertainty signals interact to enable optimal inference and learning in noisy and changeable environments. This formulation is consistent with a wealth of physiological, pharmacological, and behavioral data implicating acetylcholine and norepinephrine in specific aspects of a range of cognitive processes. Moreover, the model suggests a class of attentional cueing tasks that involve both neuromodulators and shows how their interactions may be part-antagonistic, part-synergistic.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2005.04.026

Cites

97 of 97 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
Advances in Neural Information Processing Systems 14
(2002) · The MIT Press eBooks · doi:10.7551/mitpress/1120.001.0001 · Cited by 9,187
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070
Information theory, inference, and learning algorithms
(2004) · Choice Reviews Online · doi:10.5860/choice.41-5949 · Cited by 6,536
Humans integrate visual and haptic information in a statistically optimal fashion
Ernst, M. O., & Banks, M. S. (2002) · Nature · doi:10.1038/415429a · Cited by 4,844
The Cognitive neurosciences
(2005) · Choice Reviews Online · doi:10.5860/choice.43-0626 · Cited by 4,726
Probability theory the logic of science
Jaynes, E. T., & Bretthorst, G. L. (2003) · Cited by 4,600
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627
A model for Pavlovian learning: Variations in the effectiveness of conditioned but not of unconditioned stimuli.
Pearce, J. M., & Hall, G. (1980) · Psychological Review · doi:10.1037/0033-295x.87.6.532 · Cited by 3,023
The Cognitive neurosciences
(1995) · Choice Reviews Online · doi:10.5860/choice.32-5931 · Cited by 2,337
Bayesian integration in sensorimotor learning
Körding, K. P., & Wolpert, D. M. (2004) · Nature · doi:10.1038/nature02169 · Cited by 2,004
Advances in Neural Information Processing Systems 18
Murray, I., Mackay, D., Zoubin Ghahramani, A., & Skilling, J. (2006) · Cited by 1,927
Perception as Bayesian Inference
(1996) · doi:10.1017/cbo9780511984037 · Cited by 1,425
Medial Frontal Cortex Mediates Perceptual Attentional Set Shifting in the Rat
Birrell, J. M., & Brown, V. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04320.2000 · Cited by 1,421
Cortical Map Reorganization Enabled by Nucleus Basalis Activity
Kilgard, M. P., & Merzenich, M. M. (1998) · Science · doi:10.1126/science.279.5357.1714 · Cited by 1,197
Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli
Aston‐Jones, G., & Bloom, F. E. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00887.1981 · Cited by 1,072
Event-Related Brain Potentials in Man
Donchin, E., Ritter, W., & McCallum, C. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-155150-6.x5001-9 · Cited by 956
Modulation of visual cortical plasticity by acetylcholine and noradrenaline
Bear, M. F., & Singer, W. (1986) · Nature · doi:10.1038/320172a0 · Cited by 858
Neuromodulation: acetylcholine and memory consolidation
Hasselmo, M. E. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01365-0 · Cited by 809
Information processing with population codes
Pouget, A., Dayan, P., & Zemel, R. S. (2000) · Nature reviews. Neuroscience · doi:10.1038/35039062 · Cited by 775
Self-citation
The role of locus coeruleus in the regulation of cognitive performance
Usher, M., Cohen, J. D., Servan-Schreiber, D., Rajkowski, J., & Aston-Jones, G. (1999) · Science · doi:10.1126/science.283.5401.549 · Cited by 715
Metalearning and neuromodulation
Doya, K. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00044-8 · Cited by 704
COGNITIVE PSYCHOPHYSIOLOGY: THE ENDOGENOUS COMPONENTS OF THE ERP
Donchin, E., Ritter, W., & McCallum, W. C. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-155150-6.50019-5 · Cited by 681
Cognitive functions of cortical acetylcholine: toward a unifying hypothesis
Sarter, M. F., & Bruno, J. P. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00009-4 · Cited by 675
Pattern Recognition by Self-Organizing Neural Networks
(1991) · The MIT Press eBooks · doi:10.7551/mitpress/5271.001.0001 · Cited by 599
Differential regulation of neocortical synapses by neuromodulators and activity
Gil, Z., Connors, B. W., & Amitai, Y. (1997) · Neuron · doi:10.1016/s0896-6273(00)80380-3 · Cited by 553
Expectancy and visual-spatial attention: effects on perceptual quality.
Downing, C. J. (1988) · Journal of Experimental Psychology: Human Perception and Performance · doi:10.1037/0096-1523.14.2.188 · Cited by 539
Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published erratum appears in J Neurosci 1995 Mar;15(3): following table of contents]
Voytko, M., Olton, D., Richardson, R., Gorman, L. K., Tobin, J., & Price, D. L. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00167.1994 · Cited by 520
Data Fusion for Sensory Information Processing Systems
Clark, J. J., & Yuille, A. (1990) · Springer eBooks · doi:10.1007/978-1-4757-2076-1 · Cited by 519
Neuromodulatory transmitter systems in the cortex and their role in cortical plasticity
Gu, Q. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00026-x · Cited by 518
Expectancy and visual-spatial attention: Effects on perceptual quality.
Downing, C. J. (1988) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.14.2.188 · Cited by 515
Learning and selective attention
Dayan, P., Kakade, S., & Montague, P. R. (2000) · Nature Neuroscience · doi:10.1038/81504 · Cited by 495
Self-citation
Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology
Hasselmo, M., & Schnell, E. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03898.1994 · Cited by 466
I NFERENCE AND C OMPUTATION WITH P OPULATION C ODES
Pouget, A., Dayan, P., & Zemel, R. S. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131112 · Cited by 446
Self-citation
Bayesian integration of visual and auditory signals for spatial localization
Battaglia, P., Jacobs, R. A., & Aslin, R. Ν. (2003) · Journal of the Optical Society of America A · doi:10.1364/josaa.20.001391 · Cited by 443
Reward expectation, orientation of attention and locus coeruleus‐medial frontal cortex interplay during learning
Bouret, S., & Sara, S. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03526.x · Cited by 371
Locus coeruleus activity in monkey: Phasic and tonic changes are associated with altered vigilance
Rajkowski, J., Kubiak, P., & Aston‐Jones, G. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90175-9 · Cited by 359
Cognitive functions of the basal forebrain
Baxter, M. G., & Chiba, A. A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80024-5 · Cited by 351
Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons
Jodoj, E., Chiang, C., & Aston-Jones, G. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00372-2 · Cited by 321
Response to Novelty and its Rapid Habituation in Locus Coeruleus Neurons of the Freely Exploring Rat
Vankov, A., Hervé‐Minvielle, A., & Sara, S. J. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01108.x · Cited by 309
Event-related brain potentials in man
Callaway, E., Tueting, P. A., & Koslow, S. H. (1978) · Cited by 304
Pharmacological Induction of Use-Dependent Receptive Field Modifications in the Visual Cortex
Greuel, J. M., Luhmann, H. J., & Singer, W. (1988) · Science · doi:10.1126/science.2902687 · Cited by 276
VISUOSPATIAL ATTENTION IN DEMENTIA OF THE ALZHEIMER TYPE
Parasuraman, R., Greenwood, P. M., Haxby, J. V., & Grady, C. L. (1992) · Brain · doi:10.1093/brain/115.3.711 · Cited by 274
Considerations arising from a complementary learning systems perspective on hippocampus and neocortex
McClelland, J. L., & Goddard, N. (1996) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:6 · Cited by 264
Arousal systems and attention.
Robbins, T. W., & Everitt, B. J. (1995) · Cited by 257
Noradrenergic Suppression of Synaptic Transmission May Influence Cortical Signal-to-Noise Ratio
Hasselmo, M. E., Linster, C., Patil, M., Ma, D., & Cekic, M. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.6.3326 · Cited by 229
Catecholamines and the covert orientation of attention in humans.
Clark, C. R., Geffen, G., & Geffen, L. (1989) · Neuropsychologia · doi:10.1016/0028-3932(89)90166-8 · Cited by 228
Conditioned responses of monkey locus coeruleus neurons anticipate acquisition of discriminative behavior in a vigilance task
Aston‐Jones, G., Rajkowski, J., & Kubiak, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00060-2 · Cited by 227
Phasic Activation of Monkey Locus Ceruleus Neurons by Simple Decisions in a Forced-Choice Task
Clayton, E. C., Rajkowski, J., Cohen, J. D., & Aston‐Jones, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2446-04.2004 · Cited by 226
Plasticity of sensory responses of locus coeruleus neurons in the behaving rat: implications for cognition
Sara, S. J., & Segal, M. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63835-2 · Cited by 223
Locus coeruleus-evoked responses in behaving rats: A clue to the role of noradrenaline in memory
Sara, S. J., Vankov, A., & Hervé, A. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90159-7 · Cited by 221
Cortical input to the basal forebrain
Záborszky, L., Gaykema, R. P. A., Swanson, D. J., & Cullinan, W. E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00049-3 · Cited by 221
Activation of Monkey Locus Coeruleus Neurons Varies With Difficulty and Performance in a Target Detection Task
Rajkowski, J., Majczyński, H., Clayton, E. C., & Aston‐Jones, G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00673.2003 · Cited by 215
The strength of the orienting response during Pavlovian conditioning.
Kaye, H., & Pearce, J. M. (1984) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.10.1.90 · Cited by 209
A matter of focus: monoaminergic modulation of stimulus coding in mammalian sensory networks
Hurley, L. M., Devilbiss, D. M., & Waterhouse, B. D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.06.007 · Cited by 207
Removal of Cholinergic Input to Rat Posterior Parietal Cortex Disrupts Incremental Processing of Conditioned Stimuli
Bucci, D. J., Holland, P. C., & Gallagher, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08038.1998 · Cited by 204
Activation of the noradrenergic system facilitates an attentional shift in the rat
Devauges, V., & Sara, S. J. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90118-x · Cited by 202
Acetylcholine in cortical inference
Yu, A. J., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00058-8 · Cited by 195
Self-citation
Effects of altering brain cholinergic activity on covert orienting of attention: comparison of monkey and human performance
Witte, E. A., Davidson, M. C., & Marrocco, R. T. (1997) · Psychopharmacology · doi:10.1007/s002130050352 · Cited by 187
Acetylcholine suppresses the spread of excitation in the visual cortex revealed by optical recording: possible differential effect depending on the source of input
Kimura, F., Fukuda, M., & Tsumoto, T. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00779.x · Cited by 165
Differential modulation of auditory thalamocortical and intracortical synaptic transmission by cholinergic agonist
Hsieh, C. Y., Cruikshank, S. J., & Metherate, R. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02766-9 · Cited by 165
Cholinergic modulation of responses to single tones produces tone‐specific receptive field alterations in cat auditory cortex
Metherate, R., & Weinberger, N. M. (1990) · Synapse · doi:10.1002/syn.890060204 · Cited by 164
Disruption of Decrements in Conditioned Stimulus Processing by Selective Removal of Hippocampal Cholinergic Input
Baxter, M. G., Holland, P. C., & Gallagher, M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05230.1997 · Cited by 155
Alteration of brain noradrenergic activity in rhesus monkeys affects the alerting component of covert orienting
Witte, E. A., & Marrocco, R. T. (1997) · Psychopharmacology · doi:10.1007/s002130050351 · Cited by 152
Inhibitory influence of frontal cortex on locus coeruleus neurons.
Sara, S. J., & Hervé‐Minvielle, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.6032 · Cited by 139
Chapter 28 The modular organization of brain systems. Basal forebrain: the last frontier
Záborszky, L. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36030-8 · Cited by 129
Effects of cholinergic depletion on experience-dependent plasticity in the cortex of the rat
Baskerville, K. A., Schweitzer, J. B., & Herron, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00064-x · Cited by 120
The Neural Correlates of the Noradrenergic Modulation of Human Attention, Arousal and Learning
Coull, J. T., Frith, C., Dolan, R. J., Frackowiak, R. S. J., & Grasby, P. M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01635.x · Cited by 117
Effect of scopolamine on visual attention in rats
Jones, D. N. C., & Higgins, G. A. (1995) · Psychopharmacology · doi:10.1007/bf02246186 · Cited by 115
Cholinergic neurotransmission influences covert orientation of visuospatial attention in the rat
Phillips, J. M., McAlonan, K., Robb, W. G. K., & Brown, V. J. (2000) · Psychopharmacology · doi:10.1007/s002130000437 · Cited by 107
Uncertainty and Learning
Dayan, P., & Jyu, A. (2003) · IETE Journal of Research · doi:10.1080/03772063.2003.11416335 · Cited by 105
Self-citation
SIMPLE NEURAL NETWORKS THAT OPTIMIZE DECISIONS
Brown, E., Gao, J., Holmes, P. J., Bogacz, R., Gilzenrat, M. S., & Cohen, J. D. (2005) · International Journal of Bifurcation and Chaos · doi:10.1142/s0218127405012478 · Cited by 102
Expected and Unexpected Uncertainty: ACh and NE in the Neocortex
Dayan, P., & Yu, A. J. (2002) · TUbilio (Technical University of Darmstadt) · Cited by 101
Self-citation
Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys
Prendergast, M., Jackson, W. J., Terry, A. V., Decker, M. W., Arnerić, S. P., & Buccafusco, J. J. (1998) · Psychopharmacology · doi:10.1007/s002130050538 · Cited by 99
Covert orienting of attention in macaques. I. Effects of behavioral context
Bowman, E. M., Brown, V. J., Kertzman, C., Schwarz, U., & Robinson, D. L. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.1.431 · Cited by 96
Selective removal of cholinergic neurons in the basal forebrain alters cued target detection
Chiba, A. A., Bushnell, P. J., Oshiro, W. M., & Gallagher, M. (1999) · NeuroReport · doi:10.1097/00001756-199909290-00044 · Cited by 83
Inference, Attention, and Decision in a Bayesian Neural Architecture
Yu, A. J., & Dayan, P. (2004) · MPG.PuRe (Max Planck Society) · Cited by 78
Self-citation
Suspense and surprise: On the relationship between expectancies and P3
Verleger, R., Jaśkowskí, P., & Wauschkuhn, B. (1994) · Psychophysiology · doi:10.1111/j.1469-8986.1994.tb02444.x · Cited by 73
Acetylcholine-Dependent Induction and Expression of Functional Plasticity in the Barrel Cortex of the Adult Rat
Ego‐Stengel, V., Shulz, D. E., Haidarliu, S., Sosnik, R., & Ahissar, E. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.422 · Cited by 65
The role of norepinephrine in adult rat somatosensory (SmI) cortical metabolism and plasticity
Levin, B. E., Craik, R. L., & Hand, P. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91620-4 · Cited by 63
Selective suppression of horizontal propagation in rat visual cortex by norepinephrine
Kobayashi, M., Imamura, K., Sugai, T., Onoda, N., Yamamoto, M., Komai, S., & Watanabe, Y. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00917.x · Cited by 63
Effects of (±)-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride (SIB-1553A), a Selective Ligand for Nicotinic Acetylcholine Receptors, in Tests of Visual Attention and Distractibility in Rats and Monkeys
Terry, A. V., Risbrough, V. B., Buccafusco, J. J., & Menzaghi, F. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.1.284 · Cited by 61
Noradrenergic modulation of functional selectivity in the cat visual cortex: an in vivo extracellular and intracellular study
Ego‐Stengel, V., Bringuier, V., & Shulz, D. E. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00011-8 · Cited by 53
Evidence for the involvement of presynaptic alpha-2 adrenoceptors in the regulation of norepinephrine metabolism in the rat brain.
Curet, O., Dennis, T., & Scatton, B. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22690-8 · Cited by 47
Expected and Unexpected Uncertainty: ACh and NE in the Neocortex
Yu, A., & Dayan, P. (2003) · MPG.PuRe (Max Planck Society) · Cited by 43
Self-citation
Noradrenergic-cholinergic interaction: its possible role in memory dysfunction associated with senile dementia.
Sara, S. J. (1989) · PubMed · Cited by 42
α2‐Noradrenergic effects on ERP and behavioral indices of auditory information processing
Turetsky, B. I., & Fein, G. (2002) · Psychophysiology · doi:10.1111/1469-8986.3920147 · Cited by 36
Learning by neurones: role of attention, reinforcement and behaviour
Sara, S. J. (1998) · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie · doi:10.1016/s0764-4469(97)89821-6 · Cited by 31
Automatic attentional shifts induced by a noradrenergic drug in Alzheimer’s disease: evidence from evoked potentials
Missonnier, P., Ragot, R., Derouesné, C., Guez, D., & Renault, B. (1999) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(99)00059-8 · Cited by 29
Failure to block responses of locus coeruleus neurons to somatosensory stimuli by destruction of two major afferent nuclei
Rasmussen, K., & Aghajanian, G. K. (1989) · Synapse · doi:10.1002/syn.890040210 · Cited by 28
Clonidine reverses spatial learning deficits and reinstates θ frequencies in rats with partial fornix section
Ammassari‐Teule, M., Maho, C., & Sara, S. J. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80174-3 · Cited by 28
Human and monkey P3-like responses in a mixed modality paradigm: effects of context and context-dependent noradrenergic influences
Pineda, J. A., Westerfield, M., Kronenberg, B. M., & Kubrin, J. (1997) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(97)00061-5 · Cited by 24
Noradrenergic hyperactivity after partial fornix section: role in cholinergic dependent memory performance
Sara, S. J., Dyon-Laurent, C., Guibert, B., & Leviel, V. (1992) · Experimental Brain Research · doi:10.1007/bf00229009 · Cited by 22
Noradrenergic hyperactivity in hippocampus after partial denervation: pharmacological, behavioral, and electrophysiological studies
Dyon-Laurent, C., Herv�, A., & Sara, S. J. (1994) · Experimental Brain Research · doi:10.1007/bf00239592 · Cited by 20
Functional reorganization of the noradrenergic system after partial fornix section: a behavioral and autoradiographic study
Dyon-Laurent, C., Romand, S., Biegon, A. R., & Sara, S. J. (1993) · Experimental Brain Research · doi:10.1007/bf00227100 · Cited by 17
Reduction in distractibility with AF102B and THA in the macaque
O’Neill, J., Siembieda, D. W., Crawford, K. C., Halgren, E., Fisher, A., & Fitten, L. J. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.08.006 · Cited by 14
Unifying perspectives on neuronal codes and processing
Anderson, C. H. (1996) · Lecture notes in computer science · doi:10.1007/3-540-61510-5_6 · Cited by 13

Sorted by citations

The free-energy principle: a unified brain theory?
Friston, K. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2787 · Cited by 8,120
The reorienting system of the human brain: from environment to theory of mind
Corbetta, M., Patel, G., & Shulman, G. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.017 · Cited by 3,889
Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control
Daw, N. D., Niv, Y., & Dayan, P. (2005) · Nature Neuroscience · doi:10.1038/nn1560 · Cited by 2,533
Self-citation
Learning the value of information in an uncertain world
Behrens, T. E. J., Woolrich, M. W., Walton, M. E., & Rushworth, M. F. S. (2007) · Nature Neuroscience · doi:10.1038/nn1954 · Cited by 2,053
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921

See all 1,774

Authors: Yu, A. J., & Dayan, P.
Affiliations: Gatsby Computational Neuroscience Unit (GB)
Corresponding author: Yu, Angela J.
ORCID: Yu, Angela J.
Dayan, Peter
Venue: Neuron
Publisher: Elsevier BV
Published: 2005-05
Volume: 46
Issue: 4
Pages: 681-692
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2005.04.026
OpenAlex: W2154562678
Cited by: 1,774
References: 97
Citations by year: 2026: 111 · 2025: 127 · 2024: 105 · 2023: 115 · 2022: 105 · 2021: 121 · 2020: 118 · 2019: 103 · 2018: 83 · 2017: 91 · 2016: 81 · 2015: 66 · 2014: 108 · 2013: 76 · 2012: 85
FWCI: 19.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2999 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
TUbilio (Technical University of Darmstadt) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: uncertainty, neuromodulation, acetylcholine, norepinephrine, attention, Bayesian inference, context switching, attentional cueing, prediction, noisy environments, learning
MeSH terms: Acetylcholine, Algorithms, Animals, Attention, Bayes Theorem, Computer Simulation, Dose-Response Relationship, Drug, Generalization, Psychological, Humans, Learning, Models, Neurological, Nicotine, Norepinephrine, Scopolamine, Time Factors, Likelihood Functions, Signal Detection, Psychological, Nicotinic Agonists, Muscarinic Antagonists, Maze Learning, Uncertainty, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Uncertainty, Neuromodulation, and Attention

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks