The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells
Open accessAbstract
Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB(1) receptors and protecting against excitotoxicity. Such excitotoxic brain lesions initially result in primary destruction of brain parenchyma, which attracts macrophages and microglia. These inflammatory cells release toxic cytokines and free radicals, resulting in secondary neuronal damage. In this study, we show that the endocannabinoid system is highly activated during CNS inflammation and that the endocannabinoid anandamide (AEA) protects neurons from inflammatory damage by CB(1/2) receptor-mediated rapid induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) in microglial cells associated with histone H3 phoshorylation of the mkp-1 gene sequence. As a result, AEA-induced rapid MKP-1 expression switches off MAPK signal transduction in microglial cells activated by stimulation of pattern recognition receptors. The release of AEA in injured CNS tissue might therefore represent a new mechanism of neuro-immune communication during CNS injury, which controls and limits immune response after primary CNS damage.
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“AEA inhibits microglial nitric oxide (NO) synthesis through the mitogen-activated protein kinase pathway (Eljaschewitsch et al, 2006) and inhibits tumor necrosis factor α (TNF-α) activation of the transcription nuclear factor kappa B (Sancho et al, 2003).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Eljaschewitsch et al, 2006
Citations
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Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
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Metadata
- Authors
- Eljaschewitsch, E., Witting, A., Mawrin, C., Lee, T., Schmidt, P. M., Wolf, S., Hoertnagl, H., Raine, C. S., Schneider-Stock, R., Nitsch, R., & Ullrich, O.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Washington (US)
- Charité – Universitätsmedizin Berlin (DE)
- Max Delbrück Center (DE)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Ullrich, Oliver
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 49
- Issue
- 1
- Pages
- 67-79
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1968740815
- Cited by
- 445
- References
- 76
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 12 · 2023: 14 · 2022: 26 · 2021: 17 · 2020: 10 · 2019: 16 · 2018: 13 · 2017: 18 · 2016: 25 · 2015: 29 · 2014: 23 · 2013: 20 · 2012: 31
- FWCI
- 23.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- University of Miami
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Heart, Lung, and Blood Institute (N01-HO-3284)
- National Institute of Mental Health (R24-MH-59724, R24MH059724)
- National Institute of Neurological Disorders and Stroke (NS-08952, NS-11920, R01NS008952)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- anandamide, endocannabinoid system, MKP-1, microglia, neuroinflammation, neuroprotection, CB1 receptor, CB2 receptor, MAPK signaling, histone H3 phosphorylation, neuroimmune interactions, pattern recognition receptors, excitotoxicity, secondary neuronal damage
- MeSH terms
- Adult, Animals, Arachidonic Acids, Cell Survival, Cells, Cultured, Encephalitis, Humans, Middle Aged, Multiple Sclerosis, Neurons, Nitric Oxide, Phosphoprotein Phosphatases, Phosphorylation, Tissue Distribution, Protein Tyrosine Phosphatases, Rats, Wistar, Microglia, Immediate-Early Proteins, Neuroprotective Agents, Cell Cycle Proteins, Nitric Oxide Synthase, MAP Kinase Signaling System, Receptors, Cannabinoid, Extracellular Signal-Regulated MAP Kinases, Mice, Rats, Polyunsaturated Alkamides, Dual Specificity Phosphatase 1, Protein Phosphatase 1, Cannabinoid Receptor Modulators, Endocannabinoids
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