The molecular logic of endocannabinoid signalling
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Fatty acid amide hydrolase (FAAH) catalyzes the intracellular hydrolysis of the endocannabinoid anandamide.
“Fatty acid amide hydrolase (FAAH) catalyzes the intracellular hydrolysis of the endocannabinoid anandamide.”
From Enhancement of anandamide-mediated endocannabinoid signaling corrects autism-related social impairment (2016) · cites this paper as [11]
CB1 receptors are present on presynaptic terminals of both glutamatergic projection neurons and GABAergic interneurons.
“This view is consistent with the presence of CB1 receptors on presynaptic terminals of both glutamatergic projection neurons and GABAergic interneurons.11”
From Enhancement of anandamide-mediated endocannabinoid signaling corrects autism-related social impairment (2016) · cites this paper as [11]
CB2 receptors are primarily expressed in immune cells, including myeloid, macrophage, microglia, lymphoid, and mast cells.
“In contrast, CB 2 receptors are primarily expressed in immune cells, including myeloid, macrophage, microglia, lymphoid, and mast cells (Piomelli, 2003).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Piomelli, 2003
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The endogenous cannabinoid system protects against colonic inflammation
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Spine Ca<sup>2+</sup>Signaling in Spike-Timing-Dependent Plasticity
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Cannabinoid Receptor Signaling
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Self-citationThe emerging functions of endocannabinoid signaling during CNS development
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Self-citationCannabinoids and the gut: New developments and emerging concepts
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Is lipid signaling through cannabinoid 2 receptors part of a protective system?
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- Authors
- Piomelli, D.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Piomelli, Daniele
- ORCID
- Piomelli, Daniele
- Venue
- Nature Reviews Neuroscience
- Published
- 2003-11
- Volume
- 4
- Issue
- 11
- Pages
- 873-884
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2080649553
- Cited by
- 1,957
- References
- 152
- Citations by year
- 2026: 39 · 2025: 42 · 2024: 43 · 2023: 50 · 2022: 76 · 2021: 77 · 2020: 81 · 2019: 71 · 2018: 67 · 2017: 79 · 2016: 81 · 2015: 100 · 2014: 100 · 2013: 95 · 2012: 108
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Licence
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- endocannabinoids, endocannabinoid signaling, CB1 receptor, delta-9-tetrahydrocannabinol, cannabinoid receptors, neurotransmitter release, ion channel modulation, synaptic plasticity, axon terminals
- MeSH terms
- Animals, Cannabis, gamma-Aminobutyric Acid, Hallucinogens, Humans, Synaptic Transmission, Dronabinol, Signal Transduction, Neurotransmitter Agents, Glutamic Acid, Receptor, Cannabinoid, CB1, Cannabinoid Receptor Modulators, Endocannabinoids
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