Deep Brain Stimulation for Neurologic and Neuropsychiatric Disorders
Open accessAbstract
In the 1960s, ablative stereotactic surgery was employed for a variety of movement disorders and psychiatric conditions. Although largely abandoned in the 1970s because of highly effective drugs, such as levodopa for Parkinson's disease (PD), and a reaction against psychosurgery, the field has undergone a virtual renaissance, guided by a better understanding of brain circuitry and the circuit abnormalities underlying movement disorders such as PD and neuropsychiatric conditions, such as obsessive compulsive disorder. High-frequency electrical deep brain stimulation (DBS) of specific targets, introduced in the early 1990s for tremor, has gained widespread acceptance because of its less invasive, reversible, and adjustable features and is now utilized for an increasing number of brain disorders. This review summarizes the rationale behind DBS and the use of this technique for a variety of movement disorders and neuropsychiatric diseases.
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The charge storage capacity of the iridium oxide electrodes here was observed to be larger than the charge storage capacity obtained with activated iridium oxide films reported by Agnew et al [4] and sputtered iridium oxide films reported by Cogan et al. [1].
“The charge storage capacity of the iridium oxide electrodes here was observed to be larger than the charge storage capacity obtained with activated iridium oxide films reported by Agnew et al [4] and sputtered iridium oxide films reported by Cogan et al. [1]”
From Flexible Nerve Stimulation Electrode With Iridium Oxide Sputtered on Liquid Crystal Polymer (2009) · cites this paper as [4]
Electrochemical testing of the sputtered iridium oxide films on liquid crystal polymer showed that the cathodic charge storage capacity and the injectable charge limit were higher than those obtained for activated and electrodeposited iridium oxide films [4] [5] [6] [7].
“Electrochemical testing of the sputtered iridium oxide films on liquid crystal polymer showed that the cathodic charge storage capacity and the injectable charge limit were higher than those obtained for activated and electrodeposited iridium oxide films [4] [5] [6] [7].”
From Flexible Nerve Stimulation Electrode With Iridium Oxide Sputtered on Liquid Crystal Polymer (2009) · cites this paper as [4]
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References 297 · Cited by 331
- Authors
- Wichmann, T., & DeLong, M. R.
- Affiliations
- Emory University (US)
- Corresponding author
- DeLong, Mahlon R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 52
- Issue
- 1
- Pages
- 197-204
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2026342961
- Semantic Scholar
- 4261f780c50fe6d2c12d64b0172bec1e72953f7e
- Cited by
- 331
- References
- 297
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 4 · 2023: 8 · 2022: 19 · 2021: 9 · 2020: 24 · 2019: 14 · 2018: 18 · 2017: 16 · 2016: 11 · 2015: 23 · 2014: 20 · 2013: 20 · 2012: 19
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, movement disorders, neuropsychiatric disorders, Parkinson's disease, obsessive-compulsive disorder, stereotactic neurosurgery, brain circuits, high-frequency electrical stimulation, tremor, levodopa
- MeSH terms
- Animals, Mental Disorders, Brain, Humans, Nervous System Diseases, Neural Pathways, Deep Brain Stimulation, History, 20th Century
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