Integration and Segregation of Activity in Entorhinal-Hippocampal Subregions by Neocortical Slow Oscillations
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Brain systems communicate by means of neuronal oscillations at multiple temporal and spatial scales. In anesthetized rats, we find that neocortical "slow" oscillation engages neurons in prefrontal, somatosensory, entorhinal, and subicular cortices into synchronous transitions between UP and DOWN states, with a corresponding bimodal distribution of their membrane potential. The membrane potential of hippocampal granule cells and CA3 and CA1 pyramidal cells lacked bimodality, yet it was influenced by the slow oscillation in a region-specific manner. Furthermore, in both anesthetized and naturally sleeping rats, the cortical UP states resulted in increased activity of dentate and most CA1 neurons, as well as the highest probability of ripple events. Yet, the CA3-CA1 network could self-organize into gamma bursts and occasional ripples during the DOWN state. Thus, neo/paleocortical and hippocampal networks periodically reset, self-organize, and temporally coordinate their cell assemblies via the slow oscillation.
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Generation of spindles in the thalamus and generation of SW-Rs in the hippocampus are distinctly suppressed during the down-phase of the slow oscillation, followed by a rebound in spindle and SW-R activity during the succeeding depolarizing up-state.
“Generation of spindles in the thalamus and generation of SW-Rs in the hippocampus are distinctly suppressed during the down-phase of the slow oscillation, and this is followed by a rebound in spindle and SW-R activity during the succeeding depolarizing up-state (66, 215, 597, 829 -832, 925, 1088).”
From About Sleep's Role in Memory (2013) · cites this paper as [597]
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References 68 · Cited by 500
- Authors
- Isomura, Y., Sirota, A., Özen, S., Montgomery, S., Mizuseki, K., Henze, D. A., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Buzsáki, György
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 52
- Issue
- 5
- Pages
- 871-882
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2156888897
- Cited by
- 500
- References
- 68
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 21 · 2023: 27 · 2022: 23 · 2021: 19 · 2020: 35 · 2019: 45 · 2018: 19 · 2017: 22 · 2016: 29 · 2015: 20 · 2014: 25 · 2013: 26 · 2012: 27
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2420 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH054671, MH54671)
- National Institute of Neurological Disorders and Stroke (NS043157, R01NS043157, R01NS034994, NS034994)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- up-down states, entorhinal cortex, hippocampus, hippocampal granule cells, prefrontal cortex, somatosensory cortex, subiculum, sleep, neural oscillations, network synchronization, cell assemblies
- MeSH terms
- Anesthesia, Animals, Data Interpretation, Statistical, Electrophysiology, Extracellular Matrix, Hippocampus, Male, Membrane Potentials, Nerve Net, Neurons, Sleep, Rats, Sprague-Dawley, Entorhinal Cortex, Neocortex, Rats
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