Cited by 624Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNeural dynamics and brain function

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Prefrontal Acetylcholine Release Controls Cue Detection on Multiple Timescales

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Parikh, Vinay, Kozak, Rouba, Martinez, Vicente, Sarter, Martin·2007·Neuron

Abstract

Cholinergic neurons originating from the basal forebrain innervate the entire cortical mantle. Choline-sensitive microelectrodes were used to measure the synaptic release of cortical acetylcholine (ACh) at a subsecond resolution in rats performing a task involving the detection of cues. Cues that were detected, defined behaviorally, evoked transient increases in cholinergic activity (at the scale of seconds) in the medial prefrontal cortex (mPFC), but not in a nonassociational control region (motor cortex). In trials involving missed cues, cholinergic transients were not observed. Cholinergic deafferentation of the mPFC, but not motor cortex, impaired cue detection. Furthermore, decreases and increases in precue cholinergic activity predicted subsequent cue detection or misses, respectively. Finally, cue-evoked cholinergic transients were superimposed over slower (at the timescale of minutes) changes in cholinergic activity. Cortical cholinergic neurotransmission is regulated on multiple timescales to mediate the detection of behaviorally significant cues and to support cognitive performance.

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Crossref · 10.1016/j.neuron.2007.08.025

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Metadata

Authors
Parikh, V., Kozak, R., Martinez, V., & Sarter, M.
Affiliations
University of Michigan (US)
Corresponding author
Sarter, Martin
Venue
Neuron
Publisher
Elsevier BV
Published
2007-10
Volume
56
Issue
1
Pages
141-154
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2101491694
Cited by
623
References
76
Citations by year
2026: 15 · 2025: 25 · 2024: 33 · 2023: 34 · 2022: 28 · 2021: 37 · 2020: 41 · 2019: 28 · 2018: 48 · 2017: 38 · 2016: 32 · 2015: 43 · 2014: 47 · 2013: 44 · 2012: 31
FWCI
9.39
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (1 K02 MH01072, K02MH001072, R03MH073600)
  • National Institute of Neurological Disorders and Stroke (R01NS037026, 5 R01 NS37026)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
acetylcholine release, medial prefrontal cortex, cholinergic neurotransmission, cue detection, cholinergic deafferentation, basal forebrain cholinergic neurons, motor cortex, multiple time scales, cognitive performance, rats
MeSH terms
Acetylcholine, Analysis of Variance, Animals, Appetitive Behavior, Behavior, Animal, Cues, Electrochemistry, Food Deprivation, Male, Microelectrodes, Rats, Inbred F344, Reaction Time, Reward, Time Factors, Prefrontal Cortex, Rats

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