Computational model of visual hallucination in dementia with Lewy bodies
Abstract
Patients with dementia with Lewy bodies (DLB) frequently experience visual hallucination (VH), which has been aptly described as people seeing things that are not there. The distinctive character of VH in DLB necessitates a new theory of visual cognition. We have conducted a series of studies with the aim to understand the mechanism of this dysfunction of the cognitive system. We have proposed that if we view the disease from the internal mechanism of neurocognitive processes, and if also take into consideration recent experimental data on conduction abnormality, at least some of the symptoms can be understood within the framework of network (or disconnection) syndromes. This paper describes the problem from a computational aspect and tries to determine whether conduction disturbances in a computational model can in fact produce a "computational" hallucination under appropriate assumptions.
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Previous models of VH in Lewy Body Diseases suggest a disruption on the object-related semantic network.
“as well as previous models of VH in Lewy Body Diseases suggesting a disruption on the object-related semantic network45”
From Deviations in effective connectivity explain different hallucination subtypes in Parkinson's disease psychosis (2026) · cites this paper as [45]
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“The reduced connectivity from the left PFC to the ITG, with increased PFC-V1 connectivity, appears to support this interpretation, as well as previous models of VH in Lewy Body Diseases suggesting a disruption on the object-related semantic network 45 .”
- Authors
- Tsukada, H., Fujii, H., Aihara, K., & Tsuda, I.
- Affiliations
- Hokkaido University (JP)
- Kyoto Sangyo University (JP)
- Institute of Industrial Science, The University of Tokyo (JP)
- Corresponding author
- Tsukada, Hiromichi
- Venue
- Neural Networks
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 62
- Pages
- 73-82
- ISSN
- 0893-6080 (ISSN-L)
- OpenAlex
- W1996216125
- Cited by
- 17
- References
- 56
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neural Networks (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Scientific Research on Innovative Areas (4103)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan (21120002)
- Human Frontier Science Program (HFSP:RGP0039)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- visual hallucinations, dementia with Lewy bodies, computational model, cardiac conduction disorders, disconnection syndrome, visual cognition, neurocognitive impairment
- MeSH terms
- Cognition, Computer Simulation, Hallucinations, Humans, Models, Psychological, Prefrontal Cortex, Lewy Body Disease
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