The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
Open accessAbstract
SUMMARY In the mammalian central nervous system, slow synaptic excitation involves the activation of metabotropic glutamate receptors (mGluRs). It has been proposed that C1-type transient receptor potential (TRPC1) channels underlie this synaptic excitation, but our analysis of TRPC1-deficient mice does not support this hypothesis. Here, we show unambiguously that it is TRPC3 that is needed for mGluR-dependent synaptic signaling in mouse cerebellar Purkinje cells. TRPC3 is the most abundantly expressed TRPC subunit in Purkinje cells. In mutant mice lacking TRPC3, both slow synaptic potentials and mGluR-mediated inward currents are completely absent, while the synaptically mediated Ca2+ release signals from intracellular stores are unchanged. Importantly, TRPC3 knockout mice exhibit an impaired walking behavior. Taken together, our results establish TRPC3 as a new type of postsynaptic channel that mediates mGluR-dependent synaptic transmission in cerebellar Purkinje cells and is crucial for motor coordination.
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Cites
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Li, H.-S., Xu, X.-Z. S., & Montell, C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80838-7 · Cited by 345
Cited by
Multiple Functions of Endocannabinoid Signaling in the Brain
Katona, I., & Freund, T. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150420 · Cited by 630
Consensus Paper: Cerebellar Development
Leto, K., Arancillo, M., Becker, E. B. E., Buffo, A., Chiang, C., Ding, B., Dobyns, W. B., Dusart, I., Haldipur, P., Hatten, M. E., et al. (2016) · The Cerebellum · doi:10.1007/s12311-015-0724-2 · Cited by 484
Distributed synergistic plasticity and cerebellar learning
Gao, Z., van Beugen, B. J., & De Zeeuw, C. I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3312 · Cited by 479
Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
Kohda, K., Kakegawa, W., Matsuda, S., Yamamoto, T., Hirano, H., & Yuzaki, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218380110 · Cited by 90
Metadata
- Authors
- Hartmann, J., Dragicevic, E., Adelsberger, H., Henning, H. A., Sumser, M., Abramowitz, J., Blum, R., Dietrich, A., Freichel, M., Flockerzi, V., Birnbaumer, L., & Konnerth, A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 59
- Issue
- 3
- Pages
- 392-398
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1966809675
- Cited by
- 404
- References
- 1
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hartmann, J., Dragicevic, E., Adelsberger, H., Henning, H. A., Sumser, M., Abramowitz, J., Blum, R., Dietrich, A., Freichel, M., Flockerzi, V., Birnbaumer, L., & Konnerth, A. (2008). TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination. Neuron. https://doi.org/10.1016/j.neuron.2008.06.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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