Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Open accessAbstract
Nonvoltage-gated cation currents, which are activated following stimulation of phospholipase C (PLC), appear to be major modes for Ca2+ and Na+ entry in mammalian cells. The TRPC channels may mediate some of these conductances since their expression in vitro leads to PLC-dependent cation influx. We found that the TRPC3 protein was highly enriched in neurons of the central nervous system (CNS). The temporal and spatial distribution of TRPC3 paralleled that of the neurotrophin receptor TrkB. Activation of TrkB by brain-derived nerve growth factor (BDNF) led to production of a PLC-dependent, nonselective cation conductance in pontine neurons. Evidence is provided that TRPC3 contributes to this current in vivo. Thus, activation of TrkB and PLC leads to a TRPC3-dependent cation influx in CNS neurons.
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Bath application of a low concentration (20 ng/ml) of BDNF did not by itself induce spine-head enlargement (n=30).
“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [20]
The Figure 4 caption reports that 100 ng/ml BDNF induced an inward current in isolated pontine neurons; it does not report spine-head measurements. Searches for spine-head enlargement and 20 ng/ml BDNF found no passage addressing whether that dose enlarged spine heads in 30 samples. (LLM, conf=0.76)
Experimental — accuracy not yet measuredBath application of 20 ng/ml BDNF did not by itself induce inward currents (0.5 ± 1.2 pA, n=5).
“Bath application of a low concentration (20 ng/ ml) of BDNF did not by itself induce spine-head enlargement (n = 30) (Fig. 4A) or inward currents (0.5 ± 1.2 pA, n = 5) (Fig. 4B) (19, 20).”
From Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines (2008) · cites this paper as [20]
The Figure 4 caption and the section on BDNF-activated conductance report an inward current after 100 ng/ml BDNF in isolated pontine neurons. Searches for 20 ng/ml BDNF and the reported 0.5 ± 1.2 pA (n=5) result found no passage addressing that lower-dose experiment. A response at 100 ng/ml does not establish what happens at 20 ng/ml. (LLM, conf=0.73)
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Cites
Berridge, M. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80510-3 · Cited by 2,189 · see citing works
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927 · see citing works
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T. W., & Schultz, G. (1999) · Nature · doi:10.1038/16711 · Cited by 1,496 · see citing works
Store depletion and calcium influx
Parekh, A. B., & Penner, R. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.901 · Cited by 1,420 · see citing works
Montell, C., & Rubin, G. M. (1989) · Neuron · doi:10.1016/0896-6273(89)90069-x · Cited by 1,151 · see citing works
Self-citationBerridge, M. J. (1995) · Biochemical Journal · doi:10.1042/bj3120001 · Cited by 1,099 · see citing works
Intracellular Signaling Pathways Activated by Neuropathic Factors
Segal, R. A., & Greenberg, M. E. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.002335 · Cited by 955 · see citing works
SK&F 96365, a novel inhibitor of receptor-mediated calcium entry
Merritt, J. E., Armstrong, W. P., Benham, C. D., Hallam, T. J., Jacob, R., Jaxa‐Chamiec, A. A., Leigh, B. K., McCarthy, S., Moores, K., & RINK, T. J. (1990) · Biochemical Journal · doi:10.1042/bj2710515 · Cited by 768 · see citing works
The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors
Hardie, R., & Minke, B. (1992) · Neuron · doi:10.1016/0896-6273(92)90086-s · Cited by 756 · see citing works
trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry
Zhu, M. X., Jiang, M., Peyton, M., Boulay, G., Hurst, R. S., Stefani, E., & Birnbaumer, L. (1996) · Cell · doi:10.1016/s0092-8674(00)81233-7 · Cited by 687 · see citing works
TRPC1, a human homolog of a Drosophila store-operated channel.
Wes, P. D., Chevesich, J., Jeromin, A., Rosenberg, C., Stetten, G., & Montell, C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9652 · Cited by 632 · see citing works
Self-citationFunctional interaction between InsP3 receptors and store-operated Htrp3 channels
Kiselyov, K. I., Xu, X., Mozhayeva, G. N., Kuo, T. H., Pessah, I. N., Mignery, G. A., Zhu, M. X., Birnbaumer, L., & Muallem, S. (1998) · Nature · doi:10.1038/24890 · Cited by 616 · see citing works
Self-citationtrkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
Klein, R., Parada, L. F., Coulier, F., & Barbacid, M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08545.x · Cited by 598 · see citing works
Xestospongins: Potent Membrane Permeable Blockers of the Inositol 1,4,5-Trisphosphate Receptor
Gafni, J., Munsch, J. A., Lam, T. H., Catlin, M. C., Costa, L. G., Molinski, T. F., & Pessah, I. N. (1997) · Neuron · doi:10.1016/s0896-6273(00)80384-0 · Cited by 589 · see citing works
Neurotrophic factors and their receptors.
Barbacid, M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80022-0 · Cited by 577 · see citing works
TRP2: A candidate transduction channel for mammalian pheromone sensory signaling
Liman, E. R., Corey, D. P., & Dulac, C. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5791 · Cited by 445 · see citing works
Immunocytochemical localization of TrkB in the central nervous system of the adult rat
Yan, Q., Radeke, M. J., Matheson, C. R., Talvenheimo, J., Welcher, A. A., & Felnstein, S. C. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970203)378:1 · Cited by 428 · see citing works
Zitt, C., Zobel, A., Obukhov, A. G., Harteneck, C., Kalkbrenner, F., Lückhoff, A., & Schultz, G. (1996) · Neuron · doi:10.1016/s0896-6273(00)80145-2 · Cited by 394 · see citing works
Molecular cloning of a widely expressed human homologue for the Drosophila trp gene
Zhu, M. X., Chu, P. B., Peyton, M., & Birnbaumer, L. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01038-g · Cited by 357 · see citing works
Martı́n-Zanca, D., Barbacid, M., & Parada, L. F. (1990) · Genes & Development · doi:10.1101/gad.4.5.683 · Cited by 343 · see citing works
Boulay, G., Zhu, M. X., Peyton, M., Jiang, M., Hurst, R. S., Stefani, E., & Birnbaumer, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29672 · Cited by 337 · see citing works
Zhu, M. X., Jiang, M., & Birnbaumer, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.133 · Cited by 330 · see citing works
Chen, P., Xie, H., Sekar, M. C., Gupta, K. B., & Wells, A. H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.3.847 · Cited by 325 · see citing works
A novel capacitative calcium entry channel expressed in excitable cells
Philipp, S. E., Hambrecht, J., Braslavski, L., Schroth, G., Freichel, M., Murakami, M., Cavalié, A., & Flockerzi, V. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4274 · Cited by 312 · see citing works
Coassembly of TRP and TRPL Produces a Distinct Store-Operated Conductance
Xu, X.-Z. S., Li, H.-S., Guggino, W. B., & Montell, C. (1997) · Cell · doi:10.1016/s0092-8674(00)80302-5 · Cited by 305 · see citing works
Self-citationMontell, C., & Rubin, G. M. (1988) · Cell · doi:10.1016/0092-8674(88)90413-8 · Cited by 304 · see citing works
Self-citationNeurotrophins and activity-dependent development of the neocortex
Bonhoeffer, T. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80017-1 · Cited by 297 · see citing works
Okada, T., Shimizu, S., Wakamori, M., Maeda, A., Kurosaki, T., Takada, N., Imoto, K., & Mori, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10279 · Cited by 296 · see citing works
Role of neurotrophic factors in neuronal development
Henderson, C. E. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80010-9 · Cited by 294 · see citing works
A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.
Philipp, S. E., Cavalié, A., Freichel, M., Wissenbach, U., Zimmer, S., Trost, C., Marquart, A. U., Murakami, M., & Flockerzi, V. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01004.x · Cited by 281 · see citing works
Visual Transduction in Drosophila
Montell, C. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.231 · Cited by 279 · see citing works
Self-citationVannier, B., Peyton, M., Boulay, G., Brown, D. L., Qin, N., Jiang, M., Zhu, M. X., & Birnbaumer, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2060 · Cited by 278 · see citing works
Neurotrophic factors and synaptic plasticity
Lo, D. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90085-3 · Cited by 260 · see citing works
Zitt, C., Obukhov, A. G., Strübing, C., Zobel, A., Kalkbrenner, F., Lückhoff, A., & Schultz, G. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.6.1333 · Cited by 249 · see citing works
Rescue of the Drosophila Phototransduction Mutation trp by Germline Transformation
Montell, C., Jones, K. R., Hafen, E., & Rubin, G. M. (1985) · Science · doi:10.1126/science.3933112 · Cited by 232 · see citing works
Self-citationTracing the roots of ion channels
Jan, L. Y., & Jan, Y. N. (1992) · Cell · doi:10.1016/0092-8674(92)90280-p · Cited by 229 · see citing works
Activation of recombinant trp by thapsigargin in Sf9 insect cells
Vaca, L. A., Sinkins, W. G., Hu, Y., Kunze, D. L., & Schilling, W. P. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.5.c1501 · Cited by 221 · see citing works
Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site
Twyman, R. E., Gahring, L. C., Spiess, J., & Rogers, S. W. (1995) · Neuron · doi:10.1016/0896-6273(95)90219-8 · Cited by 218 · see citing works
Characterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia
Fariñas, I., Wilkinson, G. A., Backus, C., Reichardt, L. F., & Patapoutian, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80542-5 · Cited by 193 · see citing works
Petersen, C. C. H., Berridge, M. J., Borgese, M. F., & Bennett, D. L. (1995) · Biochemical Journal · doi:10.1042/bj3110041 · Cited by 188 · see citing works
Excitement About Calcium Signaling in Inexcitable Cells
Putney, J. W. (1993) · Science · doi:10.1126/science.8235587 · Cited by 181 · see citing works
Fast actions of neurotrophic factors
Berninger, B., & Poo, M.-M. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80115-2 · Cited by 173 · see citing works
Differential Expression of MammalianTRPHomologues across Tissues and Cell Lines
Garcia, R. L., & Schilling, W. P. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7458 · Cited by 151 · see citing works
Vannier, B., Zhu, M. X., Brown, D. L., & Birnbaumer, L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8675 · Cited by 135 · see citing works
Nimchinsky, E. A., Hof, P. R., Young, W. G., & Morrison, J. H. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961007)374:1 · Cited by 105 · see citing works
Hurst, R. S., Zhu, M. X., Boulay, G., Birnbaumer, L., & Stefani, E. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00035-0 · Cited by 103 · see citing works
Structure and mRNA expression of a bovine trp homologue related to mammalian trp2 transcripts
Wissenbach, U., Schroth, G., Philipp, S. E., & Flockerzi, V. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00561-4 · Cited by 85 · see citing works
Differential distribution of TRP Ca2+ channel isoforms in mouse brain.
Mori, Y., Takada, N., Okada, T., Wakamori, M., Imoto, K., Wanifuchi, H., Oka, H., Oba, A., Ikenaka, K., & Kurosaki, T. (1998) · PubMed · Cited by 74 · see citing works
Neurotrophic factors and their receptors
Reichardt, L. F., & Isabel, F. (1998) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195111668.003.0006 · Cited by 41 · see citing works
Funayama, M., Goto, K., & Kondo, H. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00208-2 · Cited by 36 · see citing works
Calcium mobilization by inositol phosphates and other intracellular messengers
Putney, J. W., & Bird, G. S. J. (1994) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(94)p3085-l · Cited by 32 · see citing works
Neurotrophins: New roles for a seasoned cast
Shieh, P. B., & Ghosh, A. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00319-8 · Cited by 22 · see citing works
Molecular approaches to neural development
(2001) · Nature Neuroscience · doi:10.1038/nn1101-1151 · Cited by 14 · see citing works
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · see citing works
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298 · see citing works
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195 · see citing works
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060 · see citing works
Venkatachalam, K., & Montell, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142819 · Cited by 1,915 · see citing works
Self-citationThe Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
Caterina, M. J., & Julius, D. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.487 · Cited by 1,571 · see citing works
Transient Receptor Potential Cation Channels in Disease
Nilius, B., Owsianik, G., Voets, T., & Peters, J. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00021.2006 · Cited by 1,393 · see citing works
Chuang, H.-H., Prescott, E. D., Kong, H., Shields, S. D., Jordt, S. E., Basbaum, A. I., Chao, M. V., & Julius, D. J. (2001) · Nature · doi:10.1038/35082088 · Cited by 1,257 · see citing works
BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Bramham, C. R., & Messaoudi, E. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.003 · Cited by 1,193 · see citing works
Clapham, D. E., Runnels, L. W., & Strübing, C. (2001) · Nature reviews. Neuroscience · doi:10.1038/35077544 · Cited by 1,155 · see citing works
TrkB signalling pathways in LTP and learning
Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055 · see citing works
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous systemPreprint
Bibel, M., & Barde, Y. (2000) · Genes & Development · doi:10.1101/gad.841400 · Cited by 1,054 · see citing works
The TRP Superfamily of Cation Channels
Montell, C. (2005) · Science s STKE · doi:10.1126/stke.2722005re3 · Cited by 993 · see citing works
Self-citationThe neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works
The TRP Channels, a Remarkably Functional Family
Montell, C., Birnbaumer, L., & Flockerzi, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00670-0 · Cited by 880 · see citing works
Self-citationA simple role for BDNF in learning and memory?
Cunha, C. (2010) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.001.2010 · Cited by 778 · see citing works
Pedersen, S. F., Owsianik, G., & Nilius, B. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.028 · Cited by 779 · see citing works
TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain
Strübing, C., Krapivinsky, G. B., Krapivinsky, L., & Clapham, D. E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00240-9 · Cited by 729 · see citing works
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2004) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709 · see citing works
Hebb and homeostasis in neuronal plasticity
Turrigiano, G. G., & Nelson, S. B. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00091-x · Cited by 687 · see citing works
Neurotrophin secretion: current facts and future prospects
Leßmann, V., Gottmann, K., & Malcangio, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00019-4 · Cited by 664 · see citing works
BDNF signaling in context: From synaptic regulation to psychiatric disorders
Wang, C. S., Kavalali, E. T., & Monteggia, L. M. (2021) · Cell · doi:10.1016/j.cell.2021.12.003 · Cited by 629 · see citing works
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines
Tanaka, J.-I., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Science · doi:10.1126/science.1152864 · Cited by 615 · see citing works
Wu, L., Sweet, T.-B., & Clapham, D. E. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002725 · Cited by 591 · see citing works
Inoue, R., Okada, T., Onoue, H., Hara, Y., Shimizu, S., Naitoh, S., Ito, Y., & Mori, Y. (2001) · Circulation Research · doi:10.1161/01.res.88.3.325 · Cited by 596 · see citing works
TRP Channel Proteins and Signal Transduction
Minke, B., & Cook, B. (2002) · Physiological Reviews · doi:10.1152/physrev.00001.2002 · Cited by 584 · see citing works
Requirement of the Inositol Trisphosphate Receptor for Activation of Store-Operated Ca 2+ Channels
Ma, H., Patterson, R. L., van Rossum, D. B., Rossum, Birnbaumer, L., Mikoshiba, K., & Gill, D. L. (2000) · Science · doi:10.1126/science.287.5458.1647 · Cited by 577 · see citing works
Zhang, M., Ma, Y., Ye, X., Zhang, N., Pan, L., & Wang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01464-x · Cited by 548 · see citing works
Rapid vesicular translocation and insertion of TRP channels
Bezzerides, V. J., Ramsey, I. S., Kotecha, S. A., Greka, A., & Clapham, D. E. (2004) · Nature Cell Biology · doi:10.1038/ncb1150 · Cited by 520 · see citing works
Nilius, B., & SZALLASI, A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008268 · Cited by 504 · see citing works
Li, Y., Jia, Y., Cui, K., Li, N., Zheng, Z.-Y., Wang, Y., & Yuan, X. (2005) · Nature · doi:10.1038/nature03477 · Cited by 451 · see citing works
Formation of Novel TRPC Channels by Complex Subunit Interactions in Embryonic Brain
Strübing, C., Krapivinsky, G. B., Krapivinsky, L., & Clapham, D. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306705200 · Cited by 423 · see citing works
TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
Hartmann, J., Dragicevic, E., Adelsberger, H., Henning, H. A., Sumser, M., Abramowitz, J., Blum, R., Dietrich, A., Freichel, M., Flockerzi, V., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.009 · Cited by 404 · see citing works
Kiyonaka, S., Kato, K., Nishida, M., Mio, K., Numaga, T., Sawaguchi, Y., Yoshida, T., Wakamori, M., Mori, E., Numata, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808793106 · Cited by 388 · see citing works
Clapham, D. E., Julius, D. J., Montell, C., & Schultz, G. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.6 · Cited by 385 · see citing works
Self-citationPhysiology, Phylogeny, and Functions of the TRP Superfamily of Cation Channels
Montell, C. (2001) · Science s STKE · doi:10.1126/stke.2001.90.re1 · Cited by 378 · see citing works
Self-citationThe cellular and molecular basis of store-operated calcium entry
Venkatachalam, K., van Rossum, D. B., Patterson, R. L., Ma, H.-T., & Gill, D. L. (2002) · Nature Cell Biology · doi:10.1038/ncb1102-e263 · Cited by 370 · see citing works
Rattiner, L. M., Davis, M., French, C. T., & Ressler, K. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5654-03.2004 · Cited by 360 · see citing works
Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells
Rose, C. R., Blum, R., Pichler, B., Lepier, A., Kafitz, K. W., & Konnerth, A. (2003) · Nature · doi:10.1038/nature01983 · Cited by 356 · see citing works
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324 · see citing works
The mammalian TRPC cation channels
Vázquez, G., Wedel, B. J., Aziz, O., Trebak, M., & Putney, J. W. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.08.015 · Cited by 339 · see citing works
Physiology and pathophysiology of canonical transient receptor potential channels
Abramowitz, J., & Birnbaumer, L. (2008) · The FASEB Journal · doi:10.1096/fj.08-119495 · Cited by 329 · see citing works
TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation
Cheng, X., Jin, J., Hu, L. J., Shen, D., Dong, X., Samie, M. A., Knoff, J. S., Eisinger, B. E., Liu, M.-L., Huang, S. M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.013 · Cited by 326 · see citing works
Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3
Jungnickel, M. K., Marrero, H. G., Birnbaumer, L., Lémos, J. R., & Florman, H. M. (2001) · Nature Cell Biology · doi:10.1038/35074570 · Cited by 315 · see citing works
PCBs: Recent Advances in Environmental Toxicology and Health Effects
Robertson, L. W., & Hansen, L. G. (2015) · Project Muse (Johns Hopkins University) · Cited by 315 · see citing works
Presenilin-Mediated Modulation of Capacitative Calcium Entry
Yoo, A. S. J., Cheng, I., Chung, S., Grenfell‐Lee, T. Z., Lee, H., Pack-Chung, E., Handler, M., Shen, J., Xia, W., Tesco, G., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00066-0 · Cited by 309 · see citing works
Tang, J., Lin, Y., Zhang, Z., Tikunova, S. B., Birnbaumer, L., & Zhu, M. X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102316200 · Cited by 304 · see citing works
Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones
Wang, G. X., & Poo, M. (2005) · Nature · doi:10.1038/nature03478 · Cited by 297 · see citing works
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
Gottmann, K., Mittmann, T., & Leßmann, V. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1994-z · Cited by 297 · see citing works
Neurotrophin signaling: many exciting surprises!
Arévalo, J. C., & Wu, S. H. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6010-1 · Cited by 281 · see citing works
Neurotrophin-evoked depolarization requires the sodium channel NaV1.9
Blum, R., Kafitz, K. W., & Konnerth, A. (2002) · Nature · doi:10.1038/nature01085 · Cited by 266 · see citing works
Calcium Signaling in Neuronal Motility
Zheng, J. Q., & Poo, M.-M. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123221 · Cited by 292 · see citing works
ATP Excites Interneurons and Astrocytes to Increase Synaptic Inhibition in Neuronal Networks
Bowser, D. N., & Khakh, B. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2660-04.2004 · Cited by 241 · see citing works
Calcium, mitochondria and oxidative stress in neuronal pathology
Chinopoulos, C., & Ádám‐Vizi, V. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05103.x · Cited by 239 · see citing works
Hyperforin—a key constituent of St. John's wort specifically activates TRPC6 channels
Leuner, K., Kazanski, V., Müller, M., Essin, K., Henke, B., Gollasch, M., Harteneck, C., & Müller, W. E. (2007) · The FASEB Journal · doi:10.1096/fj.07-8110com · Cited by 236 · see citing works
TRPC channels promote cerebellar granule neuron survival
Jia, Y., Zhou, J. P., Tai, Y., & Wang, Y. (2007) · Nature Neuroscience · doi:10.1038/nn1870 · Cited by 235 · see citing works
Neurotrophin-Mediated Rapid Signaling in the Central Nervous System: Mechanisms and Functions
Blum, R., & Konnerth, A. (2005) · Physiology · doi:10.1152/physiol.00042.2004 · Cited by 231 · see citing works
Jung, S., Strotmann, R., Schultz, G., & Plant, T. D. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00283.2001 · Cited by 230 · see citing works
O'Toole, C. M. B., Arnoult, C., Darszon, A., Steinhardt, R. A., & Florman, H. M. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1571 · Cited by 227 · see citing works
The TRPC3/6/7 subfamily of cation channels
Trebak, M., Vázquez, G., Bird, G. S. J., & Putney, J. W. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00056-3 · Cited by 226 · see citing works
Critical role of TRPC6 channels in the formation of excitatory synapses
Zhou, J. P., Du, W., Zhou, K., Tai, Y., Yao, H., Jia, Y., Ding, Y., & Wang, Y. (2008) · Nature Neuroscience · doi:10.1038/nn.2127 · Cited by 217 · see citing works
TRPC channels: Structure, function, regulation and recent advances in small molecular probes
Wang, H., Cheng, X., Tian, J., Xiao, Y., Tian, T., Xu, F., Hong, X., & Zhu, M. X. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107497 · Cited by 210 · see citing works
Stress and trauma: BDNF control of dendritic-spine formation and regression
Bennett, M. R., & Lagopoulos, J. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.005 · Cited by 199 · see citing works
Regulation of TRPC6 Channel Activity by Tyrosine Phosphorylation
Hisatsune, C., Kuroda, Y., Nakamura, K., Inoue, T., Nakamura, T., Michikawa, T., Mizutani, A., & Mikoshiba, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311274200 · Cited by 201 · see citing works
Singh, B. B., Lockwich, T. P., Bandyopadhyay, B. C., Liu, X., Bollimuntha, S., Brazer, S.-C. W., Combs, C. A., Das, S., Leenders, A. G. M., Sheng, Z., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.010 · Cited by 200 · see citing works
Hassock, S. R., Zhu, M. X., Trost, C., Flockerzi, V., & Authi, K. S. (2002) · Blood · doi:10.1182/blood-2002-03-0723 · Cited by 197 · see citing works
GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons
Yang, F., Feng, L., Zheng, F., Johnson, S. W., Du, J., Shen, L., Wu, C.-P., & Lu, B. (2001) · Nature Neuroscience · doi:10.1038/nn734 · Cited by 193 · see citing works
N-Linked Protein Glycosylation Is a Major Determinant for Basal TRPC3 and TRPC6 Channel Activity
Dietrich, A., y Schnitzler, M. M., Emmel, J., Kalwa, H., Hofmann, T., & Gudermann, T. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302983200 · Cited by 194 · see citing works
TRP4 (CCE1) Protein Is Part of Native Calcium Release-activated Ca2+-like Channels in Adrenal Cells
Philipp, S. E., Trost, C., Warnat, J., Rautmann, J., Himmerkus, N., Schroth, G., Kretz, O., Nastainczyk, W., Cavalié, A., Hoth, M., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003408200 · Cited by 187 · see citing works
Amaral, M. D., & Pozzo-Miller, L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5499-06.2007 · Cited by 214 · see citing works
Essential Role of TRPC6 Channels in G2/M Phase Transition and Development of Human Glioma
Ding, X., He, Z., Zhou, K., Cheng, J., Yao, H., Lu, D., Cai, R., Jin, Y., Dong, B., Xu, Y., et al. (2010) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djq217 · Cited by 179 · see citing works
PKD2 Functions as an Epidermal Growth Factor-Activated Plasma Membrane Channel
Ma, R., Li, W.-P., Rundle, D., Kong, J., Akbarali, H. I., & Tsiokas, L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8285-8298.2005 · Cited by 177 · see citing works
BDNF deregulation in Rett syndrome
Li, W., & Pozzo‐Miller, L. D. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.024 · Cited by 175 · see citing works
Neuronal TRP channels: thermometers, pathfinders and life-savers
Talavera, K., Nilius, B., & Voets, T. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.03.002 · Cited by 175 · see citing works
TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway
Tai, Y., Feng, S., Ge, R., Du, W., Zhang, X., He, Z., & Wang, Y. (2008) · Journal of Cell Science · doi:10.1242/jcs.026906 · Cited by 174 · see citing works
Adachi, N., Numakawa, T., Richards, M. C., Nakajima, S., & Kunugi, H. (2014) · World Journal of Biological Chemsitry · doi:10.4331/wjbc.v5.i4.409 · Cited by 168 · see citing works
Role of Endogenous TRPC6 Channels in Ca2+ Signal Generation in A7r5 Smooth Muscle Cells
Soboloff, J., Spassova, M. A., Xu, W., He, L.-P., Cuesta, N., & Gill, D. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506064200 · Cited by 166 · see citing works
XTRPC1-dependent chemotropic guidance of neuronal growth cones
Shim, S., Goh, E. L. K., Ge, S., Sailor, K. A., Yuan, J. P., Roderick, H. L., Bootman, M. D., Worley, P. F., Song, H., & Ming, G. (2005) · Nature Neuroscience · doi:10.1038/nn1459 · Cited by 160 · see citing works
TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries
Reading, S. A., Earley, S., Waldron, B. J., Welsh, D. G., & Brayden, J. E. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00861.2004 · Cited by 161 · see citing works
Forcing open TRP channels: Mechanical gating as a unifying activation mechanism
Liu, C., & Montell, C. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.067 · Cited by 158 · see citing works
Self-citationFiorio, A., Maric, D., Brazer, S.-C. W., Giacobini, P., Liu, X., Chang, Y. H., Ambudkar, I. S., & Barker, J. L. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0951-04.2005 · Cited by 154 · see citing works
Capacitative calcium entry in the nervous system
Putney, J. W. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00143-x · Cited by 154 · see citing works
Gees, M., Owsianik, G., Nilius, B., & Voets, T. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110026 · Cited by 168 · see citing works
Vanilloid and TRP channels: a family of lipid-gated cation channels
Benham, C. D., Davis, J. B., & Randall, A. D. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00047-3 · Cited by 153 · see citing works
Dietrich, A., Kalwa, H., Rost, B. R., & Gudermann, T. W. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1460-0 · Cited by 149 · see citing works
TRPγ, a Drosophila TRP–Related Subunit, Forms a Regulated Cation Channel with TRPL
Xu, X., Chien, F., Butler, A., Salkoff, L., & Montell, C. (2000) · Neuron · doi:10.1016/s0896-6273(00)81201-5 · Cited by 151 · see citing works
Self-citationLee, Y., Kim, B. J., Kim, H. J., Yang, D. K., Zhu, M. H., Lee, K. P., So, I., & Kim, K. W. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00069.2002 · Cited by 150 · see citing works
Structure of the human lipid-gated cation channel TRPC3
Fan, C., Choi, W.-Y., Sun, W., Du, J., & Lü, W. (2018) · eLife · doi:10.7554/elife.36852 · Cited by 146 · see citing works
Homer Regulates Gain of Ryanodine Receptor Type 1 Channel Complex
Feng, W., Tu, J., Yang, T., Vernon, P. S., Allen, P. D., Worley, P. F., & Pessah, I. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207675200 · Cited by 146 · see citing works
Brain-derived neurotrophic factor
Benarroch, E. E. (2015) · Neurology · doi:10.1212/wnl.0000000000001507 · Cited by 135 · see citing works
Ben‐Shlomo, I., Hsu, S. Y., Rauch, R., Kowalski, H. W., & Hsueh, A. J. W. (2003) · Science s STKE · doi:10.1126/stke.2003.187.re9 · Cited by 135 · see citing works
TRPC3 Mediates T-cell Receptor-dependent Calcium Entry in Human T-lymphocytes
Philipp, S. E., Strauß, B., Hirnet, D., Wissenbach, U., Mery, L., Flockerzi, V., & Hoth, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304044200 · Cited by 134 · see citing works
Tozzi, A., Bengtson, C. P., Longone, P., Carignani, C., Fusco, F. R., Bernardi, G., & Mercuri, N. B. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02936.x · Cited by 132 · see citing works
McKay, R. R., Szymeczek, C. L., Lièvremont, J.-P., Bird, G. S. J., Zitt, C., Jüngling, E., Lückhoff, A., & Putney, J. W. (2000) · Biochemical Journal · doi:10.1042/bj3510735 · Cited by 130 · see citing works
Jiménez-González, C., Michelangeli, F., Harper, C. V., Barratt, C. L. R., & Publicover, S. J. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi050 · Cited by 126 · see citing works
Zitt, C., Halaszovich, C. R., & Lückhoff, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00002-3 · Cited by 126 · see citing works
Transient receptor potential channels in Alzheimer's disease
Yamamoto, S., Wajima, T., Hara, Y., Nishida, M., & Mori, Y. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.03.006 · Cited by 124 · see citing works
From modulator to mediator: rapid effects of BDNF on ion channels
Rose, C. R., Blum, R., Kafitz, K. W., Kovalchuk, Y., & Konnerth, A. (2004) · BioEssays · doi:10.1002/bies.20118 · Cited by 124 · see citing works
Ca2+ Entry Mediated by Store Depletion,S-Nitrosylation, and TRP3 Channels
van Rossum, D. B., Patterson, R. L., Ma, H.-T., & Gill, D. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003147200 · Cited by 123 · see citing works
Jacques-Fricke, B. T., Seow, Y., Gottlieb, P. A., Sachs, F., & Gómez, T. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0675-06.2006 · Cited by 122 · see citing works
- Authors
- Li, H.-S., Xu, X.-Z. S., & Montell, C.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Montell, Craig
- ORCID
- Montell, Craig
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1999-09
- Volume
- 24
- Issue
- 1
- Pages
- 261-273
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1968399538
- Cited by
- 345
- References
- 55
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 10 · 2017: 11 · 2016: 10 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 18
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY10852)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- TRPC3, TRPC channels, brain-derived neurotrophic factor, TrkB receptor, neurotrophin signaling, phospholipase C, calcium influx, sodium influx, pontine neurons, central nervous system neurons, cation conductance
- MeSH terms
- Animals, Cations, Cell Line, Cerebral Cortex, Electric Conductivity, Humans, Ion Channels, Neurons, Type C Phospholipases, Pons, Tissue Distribution, Transfection, Brain-Derived Neurotrophic Factor, Receptor, trkB, TRPC Cation Channels, Rats
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