The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers
Open accessAbstract
Summary A delineation of the molecular basis of synapse development is crucial for understanding brain function. Co-cultures of neurons with transfected fibroblastoid cells have been used to demonstrate the synapse-promoting activity of candidate molecules. Here, we performed an unbiased expression screen for synaptogenic proteins in the co-culture assay using custom-made full-length cDNA libraries. Re-isolation of NGL-3/LRRC4B and neuroligin-2 accounts for a minority of positive clones, indicating that current understanding of mammalian synaptogenic proteins is far from complete. We identify LRRTM1 as a novel transmembrane protein capable of inducing presynaptic differentiation in contacting axons. All four LRRTM family members exhibit synaptogenic activity, LRRTMs localize to excitatory synapses, and artificially-induced clustering of LRRTMs mediates postsynaptic differentiation in dendrites. We generate LRRTM1 -/- mice and reveal altered distribution of the vesicular glutamate transporter VGLUT1, confirming an in vivo synaptic function. These results suggest a prevalence of LRR domain proteins in trans-synaptic signaling and provide a cellular basis for the recently reported linkage of LRRTM1 to handedness and schizophrenia.
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Self-citationA Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
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Self-citationSynaptic AMPA receptor composition in development, plasticity and disease
Henley, J. M., & Wilkinson, K. A. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.37 · Cited by 508
Schwenk, J., Harmel, N., Brechet, A., Zolles, G., Berkefeld, H., Müller, C. S., Bildl, W., Baehrens, D., Hüber, B., Kulik, A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.034 · Cited by 433
Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein
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Metadata
- Authors
- Linhoff, M. W., Laurén, J., Cassidy, R. M., Dobie, F. A., Takahashi, H., Nygaard, H. B., Airaksinen, M. S., Strittmatter, S. M., & Craig, A. M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 61
- Issue
- 5
- Pages
- 734-749
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2024301757
- Cited by
- 358
- References
- 65
- FWCI
- 15.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Linhoff, M. W., Laurén, J., Cassidy, R. M., Dobie, F. A., Takahashi, H., Nygaard, H. B., Airaksinen, M. S., Strittmatter, S. M., & Craig, A. M. (2009). An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers. Neuron. https://doi.org/10.1016/j.neuron.2009.01.017
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