Cited by 1,938Stroke Rehabilitation and RecoveryAcute Ischemic Stroke ManagementNeurogenesis and neuroplasticity mechanisms

Plasticity during stroke recovery: from synapse to behaviour

Murphy, Timothy H., Corbett, Dale·2009·Nature Reviews Neuroscience

Abstract

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and the impairment of sensation, movement or cognition. Evidence from animal models suggests that a time-limited window of neuroplasticity opens following a stroke, during which the greatest gains in recovery occur. Plasticity mechanisms include activity-dependent rewiring and synapse strengthening. The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury.

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Crossref · 10.1038/nrn2735

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Authors
Murphy, T. H., & Corbett, D.
Affiliations
  • University of British Columbia (CA)
  • Memorial University of Newfoundland (CA)
Venue
Nature Reviews Neuroscience
Published
2009-11-04
Volume
10
Issue
12
Pages
861-872
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2045421141
Cited by
1,938
References
168
Citations by year
2026: 126 · 2025: 120 · 2024: 125 · 2023: 135 · 2022: 120 · 2021: 161 · 2020: 135 · 2019: 131 · 2018: 125 · 2017: 146 · 2016: 101 · 2015: 114 · 2014: 120 · 2013: 99 · 2012: 67
FWCI
7.83
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Heart and Stroke Foundation of British Columbia and Yukon
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
stroke recovery, neuroplasticity, behavioral recovery, developmental plasticity, animal models of stroke
MeSH terms
Animals, Brain Ischemia, Disease Models, Animal, Humans, Learning, Neuronal Plasticity, Synapses, Recovery of Function, Stroke

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