Plasticity during stroke recovery: from synapse to behaviour
Abstract
Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and the impairment of sensation, movement or cognition. Evidence from animal models suggests that a time-limited window of neuroplasticity opens following a stroke, during which the greatest gains in recovery occur. Plasticity mechanisms include activity-dependent rewiring and synapse strengthening. The challenge for improving stroke recovery is to understand how to optimally engage and modify surviving neuronal networks, to provide new response strategies that compensate for tissue lost to injury.
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A crucial time window opens in the post-acute ischaemic phase, characterised by intense neuronal sprouting, despite active inhibition of neuronal plasticity in adulthood.
“While neuronal plasticity is actively inhibited during adulthood, a crucial time window opens in the post-acute ischaemic phase that is characterised by intense neuronal sprouting.1,2”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [2]
Promotion of brain remodelling and plasticity is not limited to a sharp and well defined therapeutic window.
“The promotion of brain remodelling and plasticity is not limited to a sharp and well defined therapeutic window.1–3”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [2]
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- Authors
- Murphy, T. H., & Corbett, D.
- Affiliations
- University of British Columbia (CA)
- Memorial University of Newfoundland (CA)
- Venue
- Nature Reviews Neuroscience
- Published
- 2009-11-04
- Volume
- 10
- Issue
- 12
- Pages
- 861-872
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2045421141
- Cited by
- 1,938
- References
- 168
- Citations by year
- 2026: 126 · 2025: 120 · 2024: 125 · 2023: 135 · 2022: 120 · 2021: 161 · 2020: 135 · 2019: 131 · 2018: 125 · 2017: 146 · 2016: 101 · 2015: 114 · 2014: 120 · 2013: 99 · 2012: 67
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of British Columbia and Yukon
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- stroke recovery, neuroplasticity, behavioral recovery, developmental plasticity, animal models of stroke
- MeSH terms
- Animals, Brain Ischemia, Disease Models, Animal, Humans, Learning, Neuronal Plasticity, Synapses, Recovery of Function, Stroke
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