The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response
Open accessAbstract
Summary A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans anterior touch initiates a backward escape response in which lateral head movements are suppressed. Here we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. lgc-55 is expressed in neurons and muscle cells that receive direct synaptic inputs from tyraminergic motor neurons. Therefore, tyramine can act as a classical inhibitory neurotransmitter. Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589 · cited 4×
“In C. elegans, muscles extend cytoplasmic arms that synapse with bundles of motor neuron processes (White et al., 1986; Hall and Altun, 2007).”
BackgroundInfluentialShaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N. G., Palmer, A. E., & Tsien, R. Y. (2004) · Nature Biotechnology · doi:10.1038/nbt1037 · Cited by 4,619
The neural circuit for touch sensitivity in Caenorhabditis elegans
Chalfie, M., Sulston, J., White, J., Southgate, E., Thomson, J., & Brenner, S. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-04-00956.1985 · Cited by 1,093
Cited by
Trace Amines and Their Receptors
Gainetdinov, R. R., Hoener, M. C., & Berry, M. D. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015305 · Cited by 384
The neuronal genome of Caenorhabditis elegans
Hobert, O. (2013) · WormBook · doi:10.1895/wormbook.1.161.1 · Cited by 279
The Multilayer Connectome of Caenorhabditis elegans
Bentley, B., Branicky, R., Barnes, C. L., Chew, Y. L., Yemini, E., Bullmore, E. T., Vértes, P. E., & Schafer, W. R. (2016) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005283 · Cited by 269
Kawano, T., Po, M. D., Gao, S., Leung, G., Ryu, W. S., & Zhen, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.005 · Cited by 240
Events in Early Nervous System Evolution
Paulin, M. G., & Cahill‐Lane, J. (2021) · Topics in Cognitive Science · doi:10.1111/tops.12461 · Cited by 35
Metadata
- Authors
- Pirri, J. K., McPherson, A. D., Donnelly, J. L., Francis, M. M., & Alkema, M. J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 62
- Issue
- 4
- Pages
- 526-538
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2054014550
- Cited by
- 169
- References
- 3
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response. https://app.cochat.ai/papers/10.1016/j.neuron.2009.04.013
- The paper
- Pirri, J. K., McPherson, A. D., Donnelly, J. L., Francis, M. M., & Alkema, M. J. (2009). A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response. Neuron. https://doi.org/10.1016/j.neuron.2009.04.013
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
