The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.
The neuronal genome of Caenorhabditis elegans
Open accessAbstract
The ~100 MB genome of C. elegans codes for ~20,000 protein-coding genes many of which are required for the function of the nervous system, composed of 302 neurons in the adult hermaphrodite and of 383 neurons in the adult male. In addition to housekeeping genes, a differentiated neuron is thought to express many hundreds if not thousands of genes that define its functional properties. These genes code for ion channels, G-protein-coupled receptors, neurotransmitter-synthesizing enzymes, transporters and receptors, neuropeptides and their receptors, cell adhesion molecules, motor proteins, signaling molecules and many others. Collectively such genes have been referred to as "terminal differentiation genes" or "effector genes". The differential expression of distinct combinations of terminal differentiation genes define different neuron types. This paper provides a compendium of more than 2,800 putative terminal differentiation genes. One pervasive theme revealed by the analysis of many gene families is the nematode-specific expansions of many neuron function-related gene families, including, for example, many types of ion channel families, sensory receptors and neurotransmitter receptors. The gene lists provided here can serve multiple purposes. They can serve as quick reference guides for individual gene families or they can be used to mine large datasets (e.g., expression datasets) for genes with likely functions in the nervous system. They also serve as a starting point for future projects. For example, a comprehensive understanding of the regulation of the often complex expression patterns of these genes in the nervous system will eventually explain how nervous systems are built.
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Self-citationA cellular and regulatory map of the cholinergic nervous system of C. elegans
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Self-citationThe Multilayer Connectome of Caenorhabditis elegans
Bentley, B., Branicky, R., Barnes, C. L., Chew, Y. L., Yemini, E., Bullmore, E. T., Vértes, P. E., & Schafer, W. R. (2016) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005283 · Cited by 269
Serrano-Saiz, E., Pereira, L., Gendrel, M., Aghayeva, U., Bhattacharya, A., Howell, K., Garcia, L. R., & Hobert, O. (2017) · Genetics · doi:10.1534/genetics.117.202127 · Cited by 64
Self-citationA transcription factor collective defines the HSN serotonergic neuron regulatory landscape
Lloret-Fernández, C., Maicas, M., Mora-Martínez, C., Artacho, A., Jimeno-Martín, Á., Chirivella, L., Weinberg, P., & Flames, N. (2018) · eLife · doi:10.7554/elife.32785 · Cited by 67
Metadata
- Authors
- Hobert, O.
- Venue
- WormBook
- Publisher
- WormBook
- Published
- 2013-08-13
- Pages
- 1-106
- ISSN
- 1551-8507 (ISSN-L)
- OpenAlex
- W2037077087
- Cited by
- 279
- References
- 219
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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