The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
Open accessAbstract
Transient receptor potential A1 (TRPA1) ion channel senses a variety of noxious stimuli, and is involved in nociception. Many TRPA1 agonists covalently modify the channel and can lead to desensitization. The fate of modified TRPA1 and the mechanism of preserving its response to subsequent stimuli are not understood. Moreover, inflammatory signals sensitize TRPA1 involving protein kinase A (PKA) and phospholipase C (PLC) through unknown means. We show that TRPA1-mediated nocifensive behavior can be sensitized in vivo via PKA/PLC signaling and by activating TRPA1 with the ligand mustard oil (MO). Interestingly, both stimuli increased TRPA1 membrane levels in vitro. Tetanus toxin attenuated the response to the second of two pulses of MO in neurons, suggesting vesicle-fusion to increase functional surface TRPA1. Capacitance recordings suggest that MO can induce exocytosis. We propose that TRPA1 translocation to the membrane might represent one of the mechanisms controlling TRPA1 functionality upon acute activation or inflammatory signals.
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The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
Esteban, J. A., Shi, S.-H., Wilson, C., Nuriya, M., Huganir, R. L., & Malinow, R. (2003) · Nature Neuroscience · doi:10.1038/nn997 · Cited by 894
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745
Cited by
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Self-citationSWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
Qiu, Z., Dubin, A. E., Mathur, J., Tu, B., Reddy, K., Miraglia, L. J., Reinhardt, J., Orth, A. P., & Patapoutian, A. (2014) · Cell · doi:10.1016/j.cell.2014.03.024 · Cited by 571
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Baral, P., Udit, S., & Chiu, I. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0147-2 · Cited by 481
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
The thermo‐TRP ion channel family: properties and therapeutic implications
Vay, L., Gu, C., & McNaughton, P. A. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01601.x · Cited by 296
Metadata
- Authors
- Schmidt, M., Dubin, A. E., Petrus, M. J., Earley, T. J., & Patapoutian, A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 64
- Issue
- 4
- Pages
- 498-509
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2132676412
- Cited by
- 225
- References
- 3
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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