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Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex
Open accessAbstract
The genetic basis of cognition and behavioral adaptation to the environment remains poorly understood. Here we demonstrate that the histone methyltransferase complex GLP/G9a controls cognition and adaptive responses in a region-specific fashion in the adult brain. Using conditional mutagenesis in mice, we show that postnatal, neuron-specific deficiency of GLP/G9a leads to derepression of numerous nonneuronal and neuron progenitor genes in adult neurons. This transcriptional alteration is associated with complex behavioral abnormalities, including defects in learning, motivation, and environmental adaptation. The behavioral changes triggered by GLP/G9a deficiency are similar to key symptoms of the human 9q34 mental retardation syndrome that is associated with structural alterations of the GLP/EHMT1 gene. The likely causal role of GLP/G9a in mental retardation in mice and humans suggests a key role for the GLP/G9a-controlled histone H3K9 dimethylation in regulation of brain function through maintenance of the transcriptional homeostasis in adult neurons.
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“Researchers have reported that postnatal knockout of G9a reduced the anxiety phenotype in mice, while mutation or deletion of one copy of the GLP gene in humans leads to Kleefstra syndrome, characterized by social behavior impairment, impulsivity, aggression, and mental retardation (Schaefer et al., 2009).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Schaefer et al., 2009
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“The HMT complex G9a/G9a-like protein (GLP), composed of the HMT euchromatic histone-lysine N-methyltransferase 2 (EHMT2) or G9a and G9a-like protein (GLP or EHMT1), has been shown to be involved in the monomethylation and dimethylation of H3K9 (Schaefer et al., 2009).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Schaefer et al., 2009
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Researchers have reported that postnatal knockout of G9a reduced the anxiety phenotype in mice, while mutation or deletion of one copy of the GLP gene in humans leads to Kleefstra syndrome, characterized by social behavior impairment, impulsivity, aggression, and mental retardation (Schaefer et al., 2009).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Schaefer et al., 2009
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“Thus, G9a/GLP seems to exert temporal effects on developmental histone methylation.”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Schaefer et al., 2009
Experimental — accuracy not yet measuredIn the citing paper
“No statistical methods were used to pre-determine sample sizes but our sample sizes are similar to those reported in previous publications19,31,95,99,108.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [95]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
An efficient recombination system for chromosome engineering in Escherichia coli
Yu, D., Ellis, H. M., Lee, E.-C., Jenkins, N. A., Copeland, N. G., & Court, D. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100127597 · Cited by 1,688
Zhang, Y., & Reinberg, D. (2001) · Genes & Development · doi:10.1101/gad.927301 · Cited by 1,639
Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H., et al. (2002) · Genes & Development · doi:10.1101/gad.989402 · Cited by 1,294
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsPreprint
Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,286
Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin
Peters, A. H. F. M., Kubicek, S., Mechtler, K., O’Sullivan, R. J., Derijck, A. A. H. A., Perez-Burgos, L., Kohlmaier, A., Opravil, S., Tachibana, M., Shinkai, Y., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00477-5 · Cited by 1,208
Lee, E.-C., Yu, D., de Velasco, J. M., Tessarollo, L., Swing, D. A., Court, D. L., Jenkins, N. A., & Copeland, N. G. (2001) · Genomics · doi:10.1006/geno.2000.6451 · Cited by 1,180
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Negwer, M., Piera, K., Hesen, R., Lütje, L., Aarts, L., Schubert, D., & Kasri, N. N. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02149-9 · Cited by 15
Sharma, R. P. (2012) · Epigenomics · doi:10.2217/epi.12.46 · Cited by 16
Foret, M. R., Sandstrom, R. S., Rhodes, C. T., Wang, Y., Berger, M. S., & Lin, C. A. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00252 · Cited by 17
Chen, J., Lin, X. J., Park, K.-J., Lee, K. R., & Park, H. (2018) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-018-0156-4 · Cited by 16
Bonefas, K. M., Vallianatos, C. N., Raines, B., Tronson, N. C., & Iwase, S. (2023) · Cells · doi:10.3390/cells12040637 · Cited by 15
Gao, J., Liu, W., Liu, J., Hao, N., Pei, J., & Zhang, L. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04045-0 · Cited by 16
Ebbers, L., Runge, K., & Nothwang, H. G. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2401-2 · Cited by 15
Taniguchi, H., & Moore, A. W. (2014) · BioEssays · doi:10.1002/bies.201400087 · Cited by 17
Sharma, M., & Sajikumar, S. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy161 · Cited by 13
G9a: An Emerging Epigenetic Target for Melanoma Therapy
Flesher, J. L., & Fisher, D. E. (2021) · Epigenomes · doi:10.3390/epigenomes5040023 · Cited by 14
Itoh, Y. (2019) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c19-00741 · Cited by 15
Mariasoosai, C., Hsieh, H., & Coumar, M. S. (2018) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2018.1491422 · Cited by 14
Discovery of cysteine-targeting covalent histone methyltransferase inhibitors
Zhao, Y., Jiang, B., Gu, Z., Chen, T., Yu, W. H., Liu, S., Liu, X., Chen, D., Li, F., & Chen, W. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.115028 · Cited by 13
Wang, N., Shen, X., Bao, S., Feng, S., Wang, W., Liu, Y., Wang, Y., Wang, X., Guo, X., Shen, R., et al. (2016) · Molecular Pain · doi:10.1177/1744806916663731 · Cited by 13
Nachiyappan, A., Soon, J. L. J., Lim, H. J., Lee, V. K. M., & Taneja, R. (2021) · The Journal of Pathology · doi:10.1002/path.5848 · Cited by 13
“Similarly, conditional knockout of EHMT1 in the brain also results in upregulation of muscle-specific genes [18], indicating that EHMT1 is a global repressor of myogenesis.”
Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model
Zhang, Z., Wang, R., Zhou, H., Wu, D., Cao, Y., Zhang, C., Sun, H., Mu, C., Hao, Z., Ren, H., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05176-5 · Cited by 15
Post-transcriptional regulation of the transcriptional apparatus in neuronal development
Nazim, M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1483901 · Cited by 12
Current and Emerging Approaches Targeting G9a for the Treatment of Various Diseases.
He, H.-F., Li, X., Su, F., Jin, H., Zhang, J.-F., & Wang, Y.-X. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02781 · Cited by 11
Autism spectrum disorder model mice: Focus on copy number variation and epigenetics
Nakai, N., Otsuka, S., Myung, J., & Takumi, T. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4891-7 · Cited by 11
Yamada, A., Hirasawa, T., Nishimura, K., Shimura, C., Kogo, N., Fukuda, K., Kato, M., Yokomori, M., Hayashi, T., Umeda, M., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102741 · Cited by 12
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Scandaglia, M., & Barco, Á. (2019) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2018-105668 · Cited by 11
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Sassone‐Corsi, P., & Christen, Y. (2012) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-27913-3 · Cited by 11
An, M.-J., Kim, J., Kim, J., Kim, D.-H., Shin, G.-S., Lee, H.-M., Jo, A.-R., Park, Y., Hwangbo, Y., Kim, C.-H., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110380 · Cited by 10
Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome
Wang, S. E., Cheng, Y., Lim, J., Jang, M., Forrest, E., Kim, Y., Donahue, M., Jo, S., Qiao, S.-N., Lee, D. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61156-8 · Cited by 10
BAHD1 haploinsufficiency results in anxiety-like phenotypes in male mice
Pourpre, R., Naudon, L., Méziane, H., Lakisic, G., Jouneau, L., Varet, H., Legendre, R., Wendling, O., Selloum, M., Proux, C., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232789 · Cited by 11
Karl, M., Sommer, C., Gabriel, C. H., Hecklau, K., Venzke, M., Hennig, A. F., Radbruch, A., Selbach, M., & Baumgrass, R. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.07.031 · Cited by 10
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Gozani, O., & Shi, Y. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8624-4_5 · Cited by 8
Epigenetic Mechanisms of Mental Retardation
Schaefer, A., Tarakhovsky, A., & Greengard, P. (2010) · Springer eBooks · doi:10.1007/978-3-7643-8989-5_7 · Cited by 9
Self-citationMaintenance of neuronal fate and transcriptional identity
Aughey, G. (2023) · Biology Open · doi:10.1242/bio.059953 · Cited by 10
Reversible white matter lesions associated with mutant EHMT1 and Kleefstra syndrome
He, X., Caluseriu, O., Srivastava, R., Denny, A. M., & Bolduc, F. V. (2016) · Neurology Genetics · doi:10.1212/nxg.0000000000000058 · Cited by 8
The Role of Dynamic Histone Modifications in Learning Behavior
Fischer, A. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_108 · Cited by 8
Davis, B. A., David, F., O’Regan, C., Adam, M. A., Harwood, A. J., Crunelli, V., & Isles, A. R. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820928647 · Cited by 7
Hajar, M., Werner, T., Gajić, M., Stark, H., & Sadek, B. S. (2025) · Medicinal Research Reviews · doi:10.1002/med.22119 · Cited by 8
Weksberg, R., Butcher, D. T., Grafodatskaya, D., Choufani, S., & Tycko, B. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00006-9 · Cited by 7
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Lau, H.-T., Lewis, K. A., & Ong, S. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1142-4_12 · Cited by 8
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Bridi, M. S., & Abel, T. G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00002-1 · Cited by 8
Lysine methylation regulates nervous system diseases
Wang, Z., & Liu, H. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.04.004 · Cited by 7
Nicolay-Kritter, K., Lassalle, J., Guillou, J., & Mons, N. E. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107406 · Cited by 6
Shan, W., Wu, Y., Han, X., Chen, Q., & Wu, J. (2021) · Bioengineered · doi:10.1080/21655979.2021.1995105 · Cited by 7
Able, A., Richard, A. J., & Stephens, J. M. (2023) · Biology · doi:10.3390/biology12050674 · Cited by 7
GLP inhibits heterochromatin clustering and myogenic differentiation by repressing MeCP2
Choi, M. H., Kala, M. P., Ow, J. R., Rao, V. K., Suriyamurthy, S., & Taneja, R. (2017) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjx038 · Cited by 7
Roles of Epigenetics in the Neural Stem Cell and Neuron
Yamamoto, N., Uesaka, M., Imamura, T., & Nakashima, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00004-8 · Cited by 6
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Reul, J. M. H. M., Collins, A., & Gutièrrez‐Mecinas, M. (2011) · Springer eBooks · doi:10.1007/978-3-642-17426-1_14 · Cited by 5
Everybody's welcome: the big tent approach to epigenetic drug discovery
Green, E. M., & Gozani, O. (2011) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2011.08.002 · Cited by 5
Butler, P., Lawton, M. P., Chapin, R. E., Hollingshead, B. D., Leach, K. L., Nambiar, P. R., Pletcher, M. T., & Yang, A. H. (2015) · Royal Society of Chemistry eBooks · doi:10.1039/9781782628484-00288 · Cited by 5
Cognition and mood-related behaviors in L3mbtl1 null mutant mice
Shen, E. Y., Jiang, Y., Mao, W., Futai, K., Hock, H., & Akbarian, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121252 · Cited by 4
Bellver‐Sanchís, A., Ribalta‐Vilella, M., Lillo, J., Ortuño‐Sahagún, D., Franco, R., Pallàs, M., Navarro, G., & Griñán‐Ferré, C. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00616 · Cited by 6
Alexander, G. M., Heiman-Patterson, T. D., Bearoff, F. M., Sher, R. B., Hennessy, L., Terek, S., DeMarco, N., Cox, G. A., Philip, V. M., & Blankenhorn, E. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0274615 · Cited by 4
Clerck, M. D., Manguin, M., Henkous, N., d’Almeida, M. N., Béracochéa, D., & Mons, N. E. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1354390 · Cited by 4
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Anjum, R., REHMAN, A., Maqsood, H., ILYAS, U., Niaz, M. K., ROHAIL, MOHSIN, S., Jurrat, H., ANJUM, S., MUNAWAR, I., et al. (2023) · Biological and Clinical Sciences Research Journal · doi:10.54112/bcsrj.v2023i1.245 · Cited by 3
Tsimpos, P., Desiderio, S., Cabochette, P., Poelvoorde, P., Kricha, S., Vanhamme, L., Poulard, C., & Bellefroid, E. (2024) · Neural Development · doi:10.1186/s13064-023-00179-7 · Cited by 4
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Nordbeck, A. J., Sharma, B., Garcia, C. A., & Tseng, J. (2026) · Frontiers in Dementia · doi:10.3389/frdem.2026.1834737 · Cited by 3
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Faillace, M. P., Ortiz, J., Rocco, L., & Bernabeu, R. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03961-8 · Cited by 3
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Weaver, I. C. G. (2014) · Cell & Developmental Biology · doi:10.4172/2168-9296.1000132 · Cited by 3
A Drosophila model for the role of epigenetics in brain function and development
Stilling, R. M., & Fischer, A. (2011) · Genome biology · doi:10.1186/gb-2011-12-2-103 · Cited by 3
Quinazolines as inhibitors of chromatin-associated proteins in histones
Herrera‐Vázquez, F. S., Hernández‐Luis, F., & Medina‐Franco, J. L. (2019) · Medicinal Chemistry Research · doi:10.1007/s00044-019-02300-0 · Cited by 4
Méziane, H., Birling, M., Wendling, O., Leblanc, S., Dubos, A., Selloum, M., Pavlovic, G., Sorg, T., Kalscheuer, V. M., Billuart, P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10123148 · Cited by 4
Expression of G9a in Auditory Cortex Is Downregulated in a Rat Model of Age-Related Hearing Loss
Li, Q., Xiang, Y., Liang, X., Zhang, Y., Zhao, P., Wang, M., Bao, X.-M., Zhu, X.-B., & Deng, A. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01663-z · Cited by 3
Biss, M. (2015) · Cited by 3
Hajar, M., Jayaprakash, P., Stark, H., & Sadek, B. S. (2026) · Scientific Reports · doi:10.1038/s41598-026-38481-z · Cited by 2
Chi, L., Zhong, L., Lee, D., Yu, X., Caballero, A., Nieman, B. J., & Delgado-Olguı́n, P. (2023) · Biology Open · doi:10.1242/bio.059894 · Cited by 2
Shao, M., Gao, L., Xu, J., Zhu, L., Lu, Y., Jiang, K., Sun, J., Jiang, X., Jia, L., Zhang, A., et al. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118113 · Cited by 2
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Day, J. J., & Sweatt, J. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00005-7 · Cited by 2
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Devkota, K., Lohse, B., Jakobsen, C. N., Berthelsen, J., & Clausen, R. P. (2015) · Analytical Biochemistry · doi:10.1016/j.ab.2015.02.012 · Cited by 2
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Schaefer, A. (2012) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-27913-3_6 · Cited by 1
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Estévez, M. A., & Abel, T. G. (2011) · Springer eBooks · doi:10.1007/978-3-642-17426-1_13 · Cited by 1
Martín-González, A., Paraíso‐Luna, J., Niñerola, S., del Blanco, B., Robles, R. M., Herrera, M. L., Muñoz‐Viana, R., Geijo‐Barrientos, E., & Barco, Á. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116201 · Cited by 2
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Satterlee, J. S. (2013) · Epigenetics and human health · doi:10.1007/978-3-642-36827-1_7 · Cited by 1
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Pruvost, M., Park, H., Habermacher, C., Li, M., Angulo, M. C., Liu, J., & Casaccia, P. (2025) · Glia · doi:10.1002/glia.70014 · Cited by 1
Analogues of the natural product Sinefungin as potent inhibitors of EHMT1 and EHMT2
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The Histone Demethylase PHF8 and Neural Development*
Guo, X., Shen, Y., Bei, L. I. U., Chang, Y., & Duan, X. (2011) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2010.00390 · Cited by 1
Epigenetics and alcohol use disorders
Sagarkar, S., & Sakharkar, A. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00018-6 · Cited by 2
Kerimoglu, C. (2012) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3197 · Cited by 1
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Girgenti, M. J. (2015) · OpenCommons - UConn (University of Connecticut) · Cited by 1
Yelagandula, R., Stecher, K., Novatchkova, M., Michetti, L., Michlits, G., Wang, J., Hofbauer, P., Pribitzer, C., Vainorius, G., Isbel, L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.28.449463 · Cited by 1
Demond, H., Hanna, C. W., Fernandez, J. C., Santos, F., Papachristou, E. K., Segonds-Pichon, A., Kishore, K., D’Santos, C. S., & Kelsey, G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.20.473460 · Cited by 1
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de Jong, N. M. (2010) · Utrecht University Repository (Utrecht University)
Reul, J. M. H. M., Collins, A., & Gutièrrez‐Mecinas, M. (2011) · Wiley eBooks · doi:10.1002/9781118083222.ch5
Kim, J., Rim, J. S., Crochet, R. B., Lee, Y., Staszkiewicz, J., Gao, R., & Eilertsen, K. J. (2014) · doi:10.1002/9781118695746.ch10
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Chase, K. A. (2012) · Figshare
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Weaver, I. C. G., & Petronis, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.00097-0
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Gebicke‐Haerter, P. J. (2015) · Royal Society of Chemistry eBooks · doi:10.1039/9781782622499-00028
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Trojer, P. (2015) · Royal Society of Chemistry eBooks · doi:10.1039/9781782628484-00127
Wang, D. Y. (2016) · TSpace (University of Toronto)
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Resendiz, M. (2017) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2069
Mohanty, A., & Rampalli, S. (2018) · Springer eBooks · doi:10.1007/978-981-13-0481-1_7
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Mitrousis, N. (2018) · TSpace (University of Toronto)
Deciphering cell-type specific signal transduction in the brain: Challenges and promises
Roussarie, J.-P., & Rodriguez‐Rodriguez, P. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.09.009
Bellver‐Sanchís, A., Ávila-López, P. A., Companys‐Alemany, J., Navarro, G., Marsal-García, L., Larramona‐Arcas, R., Miró, L., Pérez‐Bosque, A., Ortuño‐Sahagún, D., Choudhary, B. S., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1228952/v1
Miyata, T., & Ichimura, A. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718167526.793488225
Roles of epigenetics in the neural stem cell and neuron
Yamamoto, N., Uesaka, M., Imamura, T., & Nakashima, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00023-4
Han, X., Zhao, Y.-C., Sun, C., Li, K., Zhao, B., Miao, J., & Su, L. (2022) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-021-00594-2
Epigenetic Regulation of Stem Cells
Mozzetta, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00258-3
Sehati, F., Hosseindoost, S., Ranjbaran, M., Nabavizadeh, F., Karimian, S. M., Adeli, S., Zahedi, E., Chodari, L., & Ashabi, G. (2024) · Drug Development Research · doi:10.1002/ddr.70001
Metadata
- Authors
- Schaefer, A., Sampath, S. C., Intrator, A., Min, A., Gertler, T. S., Surmeier, D. J., Tarakhovsky, A., & Greengard, P.
- Affiliations
- Rockefeller University (US)
- Northwestern University (US)
- Corresponding author
- Tarakhovsky, Alexander
- Greengard, Paul
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 64
- Issue
- 5
- Pages
- 678-691
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2814156
- OpenAlex
- W2065364505
- Cited by
- 317
- References
- 57
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 14 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 16 · 2019: 20 · 2018: 16 · 2017: 24 · 2016: 23 · 2015: 27 · 2014: 28 · 2013: 24 · 2012: 24
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG09464, P01AG009464)
- National Institute of Mental Health (MH-074866, F30MH082522, MH082522, P50MH074866)
- National Institute on Drug Abuse (R03DA025962, DA025962)
- National Institute of General Medical Sciences (GM 07739, R01GM112811, T32GM007739)
- National Institute of Allergy and Infectious Diseases (AI068058, R01AI068058)
- National Institute of Neurological Disorders and Stroke (P01NS013742)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- EHMT1, histone methyltransferase, epigenetic regulation, cognition, learning and memory, motivation, environmental adaptation, adult neurons
- MeSH terms
- Enhancer of Zeste Homolog 2 Protein, Adaptation, Physiological, Central Nervous System Stimulants, Animals, Animals, Newborn, Behavior, Animal, Benzazepines, Body Weight, Caffeine, Cognition, Cognition Disorders, Conditioning, Classical, Exploratory Behavior, Fear, Food Preferences, Mice, Inbred DBA, Mice, Transgenic, Motor Activity, Histone-Lysine N-Methyltransferase, Mutagenesis, Dopamine Agonists, Maze Learning, Epigenesis, Genetic, Green Fluorescent Proteins, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Polycomb Repressive Complex 2
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