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Divisive Normalization in Olfactory Population Codes
Open accessAbstract
In many regions of the visual system, the activity of a neuron is normalized by the activity of other neurons in the same region. Here we show that a similar normalization occurs during olfactory processing in the Drosophila antennal lobe. We exploit the orderly anatomy of this circuit to independently manipulate feedforward and lateral input to second-order projection neurons (PNs). Lateral inhibition increases the level of feedforward input needed to drive PNs to saturation, and this normalization scales with the total activity of the olfactory receptor neuron (ORN) population. Increasing total ORN activity also makes PN responses more transient. Strikingly, a model with just two variables (feedforward and total ORN activity) accurately predicts PN odor responses. Finally, we show that discrimination by a linear decoder is facilitated by two complementary transformations: the saturating transformation intrinsic to each processing channel boosts weak signals, while normalization helps equalize responses to different stimuli.
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Metadata
- Authors
- Olsen, S. R., Bhandawat, V., & Wilson, R. I.
- Affiliations
- Harvard University (US)
- Corresponding author
- Wilson, Rachel I.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 66
- Issue
- 2
- Pages
- 287-299
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2866644
- OpenAlex
- W2138260451
- Cited by
- 500
- References
- 56
- Citations by year
- 2026: 20 · 2025: 38 · 2024: 26 · 2023: 29 · 2022: 30 · 2021: 46 · 2020: 31 · 2019: 53 · 2018: 29 · 2017: 29 · 2016: 35 · 2015: 21 · 2014: 27 · 2013: 31 · 2012: 26
- FWCI
- 11.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1203 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- McKnight Foundation
- Charles A. King Trust
- National Institutes of Health (R01DC008174)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- divisive normalization, antennal lobe, projection neurons, lateral inhibition, olfactory sensory neurons, signal saturation, transient response, odor discrimination, linear decoder, Drosophila olfaction
- MeSH terms
- Animals, Drosophila, Electrophysiology, Models, Neurological, Nerve Net, Neural Inhibition, Synaptic Transmission, Odorants, Olfactory Pathways, Signal Processing, Computer-Assisted, Smell, Olfactory Receptor Neurons
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