The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
AMPA Receptor Synaptic Plasticity Induced by Psychostimulants: The Past, Present, and Therapeutic Future
Open accessAbstract
Experience-dependent plasticity at excitatory synapses of the mesocorticolimbic system is a fundamental brain mechanism that enables adaptation to an ever-changing environment. These synaptic responses are critical for the planning and execution of adaptive behaviors that maximize survival. The mesocorticolimbic system mediates procurement of positive reinforcers such as food and sex; however, drugs of abuse re-sculpt this crucial circuitry to promote compulsive drug-seeking behavior. This review will discuss the long-term changes in glutamatergic neurotransmission that occur within the mesolimbic system following cocaine exposure. In addition, we will examine how these long-lasting neuroadaptations may drive the pathology of psychostimulant addiction. Finally, we review clinical trials that highlight antagonists at excitatory AMPA receptors as promising targets against cocaine abuse.
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Cites
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Cited by
The brain on drugs: from reward to addiction
Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
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One Is Not Enough: Understanding and Modeling Polysubstance Use
Crummy, E. A., O’Neal, T. J., Baskin, B. M., & Ferguson, S. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00569 · Cited by 351
New medications for drug addiction hiding in glutamatergic neuroplasticity
Kalivas, P. W., & Volkow, N. D. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.46 · Cited by 349
Mameli, M., Bellone, C., Brown, M. T. C., & Lüscher, C. (2011) · Nature Neuroscience · doi:10.1038/nn.2763 · Cited by 177
Metadata
- Authors
- Bowers, M. S., Chen, B. T., & Bonci, A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 67
- Issue
- 1
- Pages
- 11-24
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2127367225
- Cited by
- 220
- References
- 33
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bowers, M. S., Chen, B. T., & Bonci, A. (2010). AMPA Receptor Synaptic Plasticity Induced by Psychostimulants: The Past, Present, and Therapeutic Future. Neuron. https://doi.org/10.1016/j.neuron.2010.06.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
