Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works

A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · see citing works

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885 · see citing works

Opioids excite dopamine neurons by hyperpolarization of local interneurons

Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637 · see citing works

Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum

Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610 · see citing works

Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex

Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works

Synaptic plasticity and addiction

Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397 · see citing works

Is there a common molecular pathway for addiction?

Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388 · see citing works

Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies

Vanderschuren, L. J. M. J., & Kalivas, P. W. (2000) · Psychopharmacology · doi:10.1007/s002130000493 · Cited by 1,337 · see citing works

Mechanisms of neurotransmitter release by amphetamines: A review

Sulzer, D. L., Sonders, M. S., Poulsen, N. W., & Galli, A. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.04.003 · Cited by 1,212 · see citing works

D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons

Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203 · see citing works

Dichotomous dopaminergic control of striatal synaptic plasticity

Shen, W., Flajolet, M., Greengard, P., & Surmeier, D. J. (2008) · Science · doi:10.1126/science.1160575 · Cited by 1,190 · see citing works

Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons

Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147 · see citing works

Evidence for Addiction-like Behavior in the Rat

Deroche-Gamonet, V., Belin, D., & Piazza, P. V. (2004) · Science · doi:10.1126/science.1099020 · Cited by 1,135 · see citing works

Subsecond dopamine release promotes cocaine seeking

Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113 · see citing works

Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106 · see citing works

Striatal Plasticity and Basal Ganglia Circuit Function

Kreitzer, A. C., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.005 · Cited by 1,009 · see citing works

Incubation of cocaine craving after withdrawal

Grimm, J. W., Hope, B. T., Wise, R. A., & Shaham, Y. (2001) · Nature · doi:10.1038/35084134 · Cited by 1,003 · see citing works

Cortico-Basal Ganglia Reward Network: Microcircuitry

Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985 · see citing works

Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system

Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976 · see citing works

The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants

Wolf, M. E. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00090-7 · Cited by 934 · see citing works

Varenicline:  An α4β2 Nicotinic Receptor Partial Agonist for Smoking Cessation

Coe, J. W., Brooks, P. R., Vetelino, M. G., Wirtz, M. C., Arnold, E. P., Huang, J., Sands, S. B., Davis, T. I., Lebel, L. A., Fox, C. B., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050069n · Cited by 930 · see citing works

Encoding of conditioned fear in central amygdala inhibitory circuits

Ciocchi, S., Herry, C., Grenier, F., Wolff, S. B. E., Letzkus, J. J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M. B., et al. (2010) · Nature · doi:10.1038/nature09559 · Cited by 924 · see citing works

Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward

Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., Dietz, D. M., Zaman, S., Koo, J. W., Kennedy, P. J., et al. (2010) · Science · doi:10.1126/science.1188472 · Cited by 880 · see citing works

Genetic dissection of an amygdala microcircuit that gates conditioned fear

Haubensak, W., Kunwar, P. S., Cai, H., Ciocchi, S., Wall, N. R., Ponnusamy, R., Biag, J., Dong, H.-W., Deisseroth, K., Callaway, E. M., et al. (2010) · Nature · doi:10.1038/nature09553 · Cited by 840 · cited 2× · see citing works

The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity

Isaac, J. T. R., Ashby, M. C., & McBain, C. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.001 · Cited by 802 · see citing works

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

Conrad, K. L., Tseng, K. Y., Uejima, J. L., Reimers, J. M., Heng, L.-J., Shaham, Y., Marinelli, M., & Wolf, M. E. (2008) · Nature · doi:10.1038/nature06995 · Cited by 790 · see citing works

Dendritic release of dopamine in the substantia nigra

Chéramy, A., Leviel, V., & Glowinski, J. (1981) · Nature · doi:10.1038/289537a0 · Cited by 738 · see citing works

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

Kreitzer, A. C., & Malenka, R. C. (2007) · Nature · doi:10.1038/nature05506 · Cited by 735 · see citing works

Drug Addiction as a Pathology of Staged Neuroplasticity

Kalivas, P. W., & O’Brien, C. P. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301564 · Cited by 735 · see citing works

Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine

Borgland, S. L., Taha, S. A., Sarti, F., Fields, H. L., & Bonci, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.016 · Cited by 718 · see citing works

Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum

Belin, D., & Everitt, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.019 · Cited by 697 · see citing works

The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens

Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.002 · Cited by 654 · see citing works

Self-inhibition by Dopaminergic Neurons

Groves, P. M., Wilson, C. J., Young, S. J., & Rebec, G. V. (1975) · Science · doi:10.1126/science.242074 · Cited by 642 · see citing works

Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens

Robbe, D., Köpf, M., Rémaury, A., Bockaert, J., & Manzoni, O. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122149199 · Cited by 631 · see citing works

Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine

Thomas, M. J., Beurrier, C., Bonci, A., & Malenka, R. C. (2001) · Nature Neuroscience · doi:10.1038/nn757 · Cited by 629 · see citing works

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

Lüscher, C., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.016 · Cited by 627 · see citing works

Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior

Hikida, T., Kimura, K., Wada, N., Funabiki, K., & Nakanishi, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.011 · Cited by 592 · see citing works

Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors

Maskos, U., Molles, B. E., Pons, S., Besson, M., Guiard, B. P., Guilloux, J.-P., Evrard, A., Cazala, P., Cormier, A., Mameli-Engvall, M., et al. (2005) · Nature · doi:10.1038/nature03694 · Cited by 566 · cited 1× · see citing works

Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death

Liu, S. J., & Zukin, R. S. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.01.006 · Cited by 530 · see citing works

Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate

Stuber, G. D., Hnasko, T. S., Britt, J. P., Edwards, R. H., & Bonci, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1754-10.2010 · Cited by 529 · see citing works

The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?

Margolis, E. B., Lock, H., Hjelmstad, G. O., & Fields, H. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117069 · Cited by 527 · see citing works

Neuroplasticity in the mesolimbic dopamine system and cocaine addiction

Thomas, M. J., Kalivas, P. W., & Shaham, Y. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.77 · Cited by 513 · see citing works

A unified framework for addiction: Vulnerabilities in the decision process

Redish, A. D., Jensen, S., & Johnson, A. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0800472x · Cited by 501 · see citing works

Behavioral Sensitization to Cocaine Is Associated with Increased AMPA Receptor Surface Expression in the Nucleus Accumbens

Boudreau, A. C., & Wolf, M. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2252-05.2005 · Cited by 481 · see citing works

Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons

Gertler, T. S., Chan, C. S., & Surmeier, D. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2660-08.2008 · Cited by 469 · see citing works

Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning

Witten, I. B., Lin, S.-C., Brodsky, M., Prakash, R., Diester, I., Anikeeva, P., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2010) · Science · doi:10.1126/science.1193771 · Cited by 467 · see citing works

Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens

Kourrich, S., Rothwell, P. E., Klug, J. R., & Thomas, M. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1859-07.2007 · Cited by 429 · see citing works

Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression

Bellone, C., & Lüscher, C. (2006) · Nature Neuroscience · doi:10.1038/nn1682 · Cited by 429 · see citing works

Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior

Zweifel, L. S., Parker, J. G., Lobb, C. J., Rainwater, A., Wall, V. Z., Fadok, J. P., Darvas, M., Kim, M. J., Mizumori, S. J. Y., Paladini, C. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813415106 · Cited by 426 · see citing works

N-Acetylcysteine reverses cocaine-induced metaplasticity

Moussawi, K., Pacchioni, A. M., Moran, M., Olive, M. F., Gass, J. T., Lavı́n, A., & Kalivas, P. W. (2009) · Nature Neuroscience · doi:10.1038/nn.2250 · Cited by 400 · see citing works

Neural bases for addictive properties of benzodiazepines

Tan, K. R., Brown, M., Labouèbe, G., Yvon, C., Creton, C., Fritschy, J.-M., Rudolph, U., & Lüscher, C. (2010) · Nature · doi:10.1038/nature08758 · Cited by 397 · see citing works

Glutamate transmission in addiction

Kalivas, P. W., LaLumiere, R. T., Knackstedt, L. A., & Shen, H. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.011 · Cited by 389 · see citing works

Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity

Yao, W., Gainetdinov, R. R., Arbuckle, M. I., Sotnikova, T. D., Cyr, M., Beaulieu, J., Torres, G. E., Grant, S. G. N., & Caron, M. G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00048-0 · Cited by 380 · see citing works

Monosynaptic circuit tracing in vivo through Cre-dependent targeting and complementation of modified rabies virus

Wall, N. R., Wickersham, I. R., Cetin, A. H., Parra, M. D. L., & Callaway, E. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011756107 · Cited by 369 · see citing works

Vesicular Dopamine Release Elicits an Inhibitory Postsynaptic Current in Midbrain Dopamine Neurons

Beckstead, M. J., Grandy, D. K., Wickman, K. D., & Williams, J. T. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.019 · Cited by 368 · see citing works

Involvement of N-methyl-D-aspartate receptor stimulation in the ventral tegmental area and amygdala in behavioral sensitization to cocaine.

Kalivas, P. W., & Alesdatter, J. E. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39530-3 · Cited by 368 · see citing works

Glutamatergic neurons are present in the rat ventral tegmental area

Yamaguchi, T., Sheen, W., & Morales, M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05263.x · Cited by 367 · see citing works

Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system

Cruz, H. G., Ivanova, T., Lunn, M.-L., Stoffel, M., Slesinger, P. A., & Lüscher, C. (2004) · Nature Neuroscience · doi:10.1038/nn1181 · Cited by 367 · see citing works

Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity

Kasanetz, F., Deroche‐Gamonet, V., Berson, N., Balado, É., Lafourcade, M., Manzoni, O. J., & Piazza, P. V. (2010) · Science · doi:10.1126/science.1187801 · Cited by 364 · see citing works

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors

Bateup, H. S., Santini, E., Shen, W., Birnbaum, S. G., Valjent, E., Surmeier, D., Fisone, G., Nestler, E. J., & Greengard, P. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1009874107 · Cited by 361 · see citing works

Cocaine but Not Natural Reward Self-Administration nor Passive Cocaine Infusion Produces Persistent LTP in the VTA

Chen, B. T., Bowers, M. S., Martín, M., Hopf, F. W., Guillory, A. M., Carelli, R. M., Chou, J., & Bonci, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.024 · Cited by 353 · see citing works

Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens

Grueter, B. A., Brasnjo, G., & Malenka, R. C. (2010) · Nature Neuroscience · doi:10.1038/nn.2685 · Cited by 353 · see citing works

TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

Chávez, A. E., Chiu, C. Q., & Castillo, P. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2684 · Cited by 351 · see citing works

Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc

Mameli, M., Halbout, B., Creton, C., Engblom, D., Parkitna, J. M. R., Spanagel, R., & Lüscher, C. (2009) · Nature Neuroscience · doi:10.1038/nn.2367 · Cited by 340 · see citing works

Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens

Tecuapetla, F., Patel, J. C., Xenias, H., English, D., Tadros, I., Shah, F., Berlin, J., Deisseroth, K., Rice, M. E., Tepper, J. M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0265-10.2010 · Cited by 310 · see citing works

Reward-Predictive Cues Enhance Excitatory Synaptic Strength onto Midbrain Dopamine Neurons

Stuber, G. D., Klanker, M., de Ridder, B., Bowers, M. S., Joosten, R. N. J. M. A., Feenstra, M. G. P., & Bonci, A. (2008) · Science · doi:10.1126/science.1160873 · Cited by 307 · see citing works

Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons

Liu, Q.-S., Pu, L., & Poo, M. (2005) · Nature · doi:10.1038/nature04050 · Cited by 305 · see citing works

Opioids block long-term potentiation of inhibitory synapses

Nugent, F. S., Penick, E. C., & Kauer, J. A. (2007) · Nature · doi:10.1038/nature05726 · Cited by 297 · see citing works

Corticotropin-Releasing Factor Requires CRF Binding Protein to Potentiate NMDA Receptors via CRF Receptor 2 in Dopamine Neurons

Ungless, M. A., Singh, V., Crowder, T. L., Yaka, R., Ron, D., & Bonci, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00461-6 · Cited by 297 · see citing works

In Vivo Cocaine Experience Generates Silent Synapses

Huang, Y. H., Lin, Y., Mu, P., Lee, B. R., Brown, T. E., Wayman, G. A., Marie, H., Liu, W., Yan, Z., Sorg, B. A., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.007 · Cited by 290 · see citing works

Nucleus Accumbens Long-Term Depression and the Expression of Behavioral Sensitization

Brebner, K., Wong, T. P., Liu, L., Liu, Y., Campsall, P. A., Gray, S. L., Phelps, L., Phillips, A. G., & Wang, Y. T. (2005) · Science · doi:10.1126/science.1116894 · Cited by 289 · see citing works

Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse?

Carlezon, W. A., & Nestler, E. J. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02289-0 · Cited by 281 · see citing works

Cell Surface AMPA Receptors in the Rat Nucleus Accumbens Increase during Cocaine Withdrawal But Internalize after Cocaine Challenge in Association with Altered Activation of Mitogen-Activated Protein Kinases

Boudreau, A. C., Reimers, J. M., Milovanovic, M., & Wolf, M. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2163-07.2007 · Cited by 277 · see citing works

SHORT COMMUNICATION Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids

Szabó, B., Siemes, S., & Wallmichrath, I. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02041.x · Cited by 277 · see citing works

AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine

Wolf, M. E., & Ferrario, C. R. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.013 · Cited by 271 · see citing works

Rapid Synthesis and Synaptic Insertion of GluR2 for mGluR-LTD in the Ventral Tegmental Area

Mameli, M., Balland, B., Luján, R., & Lüscher, C. (2007) · Science · doi:10.1126/science.1142365 · Cited by 265 · see citing works

Silent synapses speak up

Malenka, R. C., & Nicoll, R. A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80362-1 · Cited by 257 · see citing works

Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons

Dobi, A., Margolis, E. B., Wang, H.-L., Harvey, B. K., & Morales, M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3884-09.2010 · Cited by 257 · see citing works

The Mechanistic Classification of Addictive Drugs

Lüscher, C., & Ungless, M. A. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030437 · Cited by 255 · see citing works

Cocaine‐induced neuroadaptations in glutamate transmission

Schmidt, H. D., & Pierce, R. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05144.x · Cited by 254 · see citing works

Mechanism and Time Course of Cocaine-Induced Long-Term Potentiation in the Ventral Tegmental Area

Argilli, E., Sibley, D. R., Malenka, R. C., England, P. M., & Bonci, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1001-08.2008 · Cited by 243 · see citing works

Glutamate Receptors on Dopamine Neurons Control the Persistence of Cocaine Seeking

Engblom, D., Bilbao, A., Sanchis‐Segura, C., Dahan, L., Perreau‐Lenz, S., Balland, B., Parkitna, J. M. R., Luján, R., Halbout, B., Mameli, M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.010 · Cited by 241 · see citing works

Midbrain Dopamine Neurons: Projection Target Determines Action Potential Duration and Dopamine D 2 Receptor Inhibition

Margolis, E. B., Mitchell, J., Ishikawa, J., Hjelmstad, G. O., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-08.2008 · Cited by 232 · see citing works

Drd1a-tdTomato BAC Transgenic Mice for Simultaneous Visualization of Medium Spiny Neurons in the Direct and Indirect Pathways of the Basal Ganglia

Shuen, J. A., Chen, M., Gloss, B. R., & Calakos, N. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5492-07.2008 · Cited by 231 · see citing works

The Bermuda Triangle of cocaine-induced neuroadaptations

Wolf, M. E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.06.003 · Cited by 228 · see citing works

A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Mato, S., Chevaleyre, V., Robbe, D., Pazos, Á., Castillo, P. E., & Manzoni, O. J. (2004) · Nature Neuroscience · doi:10.1038/nn1251 · Cited by 220 · see citing works

Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB

Marie, H., Morishita, W., Yu, X., Calakos, N., & Malenka, R. C. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.039 · Cited by 219 · see citing works

Nucleus Accumbens Medium Spiny Neurons Target Non-Dopaminergic Neurons in the Ventral Tegmental Area

Xia, Y., Driscoll, J. R., Wilbrecht, L., Margolis, E. B., Fields, H. L., & Hjelmstad, G. O. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1504-11.2011 · Cited by 218 · see citing works

AMPA Receptor Synaptic Plasticity Induced by Psychostimulants: The Past, Present, and Therapeutic Future

Bowers, M. S., Chen, B. T., & Bonci, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.004 · Cited by 218 · see citing works

Role of NMDA Receptors in Dopamine Neurons for Plasticity and Addictive Behaviors

Zweifel, L. S., Argilli, E., Bonci, A., & Palmiter, R. D. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.028 · Cited by 210 · see citing works

A SingleIn VivoExposure to Cocaine Abolishes Endocannabinoid-Mediated Long-Term Depression in the Nucleus Accumbens

Fourgeaud, L., Mato, S., Bouchet, D., Hémar, A., Worley, P. F., & Manzoni, O. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0671-04.2004 · Cited by 207 · see citing works

Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking

Van den Oever, M. C., Goriounova, N. A., Wan Li, K., Van der Schors, R. C., Binnekade, R., Schoffelmeer, A. N. M., Mansvelder, H. D., Smit, A. B., Spijker, S., & De Vries, T. J. (2008) · Nature Neuroscience · doi:10.1038/nn.2165 · Cited by 206 · see citing works

Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens

Martín, M., Chen, B. T., Hopf, F. W., Bowers, M. S., & Bonci, A. (2006) · Nature Neuroscience · doi:10.1038/nn1713 · Cited by 205 · see citing works

Dopamine-Dependent Interactions between Limbic and Prefrontal Cortical Plasticity in the Nucleus Accumbens: Disruption by Cocaine Sensitization

Goto, Y., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.017 · Cited by 204 · see citing works

Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area

Rodaros, D., Caruana, D. A., Amir, S., & Stewart, J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.043 · Cited by 194 · see citing works

Interactions between dopamine and excitatory amino acids in behavioral sensitization to psychostimulants

Kalivas, P. W. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(94)01063-q · Cited by 192 · see citing works

Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area

Mameli, M., Bellone, C., Brown, M. T. C., & Lüscher, C. (2011) · Nature Neuroscience · doi:10.1038/nn.2763 · Cited by 177 · see citing works

Critical Role for Ventral Tegmental Glutamate in Preference for a Cocaine-Conditioned Environment

Harris, G. C., & Aston‐Jones, G. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300011 · Cited by 163 · see citing works

NMDA receptors inhibit synapse unsilencing during brain development

Adesnik, H., Li, G., During, M. J., Pleasure, S. J., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800946105 · Cited by 161 · see citing works

Glutamate and reinstatement

Knackstedt, L. A., & Kalivas, P. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.003 · Cited by 159 · see citing works

Cocaine-induced potentiation of synaptic strength in dopamine neurons: Behavioral correlates in GluRA(–/–) mice

Dong, Y., Saal, D., Thomas, M., Faust, R., Bonci, A., Robinson, T., & Malenka, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401553101 · Cited by 158 · see citing works

Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5Receptor-Dependent Redistribution of NMDA Receptors

Schilström, B., Yaka, R., Argilli, E., Suvarna, N. U., Schumann, J., Chen, B. T., Carman, M., Singh, V., Mailliard, W. S., Dorit Ron, A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5179-05.2006 · Cited by 147 · see citing works

Glutamate-associated plasticity in the ventral tegmental area is necessary for conditioning environmental stimuli with morphine

Harris, G. C., Wimmer, M. E., Byrne, R., & Aston‐Jones, G. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.018 · Cited by 145 · see citing works

Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area

Niehaus, J. L., Murali, M., & Kauer, J. A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07256.x · Cited by 140 · see citing works

Synaptic plasticity in the mesolimbic dopamine system

Thomas, M. J., & Malenka, R. C. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1236 · Cited by 137 · see citing works

Elevated BDNF after Cocaine Withdrawal Facilitates LTP in Medial Prefrontal Cortex by Suppressing GABA Inhibition

Lü, H., Cheng, P., Lim, B. K., Khoshnevisrad, N., & Poo, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.012 · Cited by 134 · see citing works

BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal

Pu, L., Liu, Q.-S., & Poo, M. (2006) · Nature Neuroscience · doi:10.1038/nn1687 · Cited by 133 · see citing works

mGluRs induce a long‐term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors

Bellone, C., & Lüscher, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03979.x · Cited by 129 · see citing works

Drug-Driven AMPA Receptor Redistribution Mimicked by Selective Dopamine Neuron Stimulation

Brown, M. T. C., Bellone, C., Mameli, M., Labouèbe, G., Bocklisch, C., Balland, B., Dahan, L., Luján, R., Deisseroth, K. A., & Lüscher, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015870 · Cited by 112 · see citing works

Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex

Ben‐Shahar, O., Obara, I., Ary, A. W., Ma, N., Mangiardi, M., Medina, R. L., & Szumlinski, K. K. (2009) · Synapse · doi:10.1002/syn.20640 · Cited by 107 · see citing works

Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons

Vittoz, N. M., Schmeichel, B. E., & Berridge, C. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06453.x · Cited by 104 · see citing works

Long-term potentiation at excitatory amino acid synapses on midbrain dopamine neurons

Overton, P. G., Richards, C. D., Berry, M. S., & Clark, D. T. (1999) · Neuroreport · doi:10.1097/00001756-199902050-00004 · Cited by 103 · see citing works

Induction of locomotor sensitization by amphetamine requires the activation of NMDA receptors in the rat ventral tegmental area

Vezina, P., & Queen, A. L. (2000) · Psychopharmacology · doi:10.1007/s002130000463 · Cited by 88 · see citing works

Convergent actions of orexin/hypocretin and CRF on dopamine neurons: Emerging players in addiction

Borgland, S. L., Ungless, M. A., & Bonci, A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.10.068 · Cited by 75 · see citing works

PKG and PKA Signaling in LTP at GABAergic Synapses

Nugent, F. S., Niehaus, J. L., & Kauer, J. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.5 · Cited by 73 · see citing works

Autoregulation and monoamine interactions in the ventral tegmental area in the absence and presence of cocaine: a microdialysis study in freely moving rats.

Chen, N., & Reith, M. E. A. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24047-2 · Cited by 66 · see citing works

Repeated Administration of Amphetamine or Cocaine Does Not Alter AMPA Receptor Subunit Expression in the Rat Midbrain,

Lü, W. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00272-x · Cited by 63 · see citing works

Electrophysiological responses of neurons of the ventral tegmental area to electrical stimulation of amygdala and lateral septum

Maeda, H., & Mogenson, G. J. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90130-5 · Cited by 61 · see citing works

Ethanol Blocks Long-Term Potentiation of GABAergic Synapses in the Ventral Tegmental Area Involving μ-Opioid Receptors

Guan, Y., & Ye, J.-H. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.51 · Cited by 57 · see citing works

Cocaine Self-Administration Reduces Excitatory Responses in the Mouse Nucleus Accumbens Shell

Schramm‐Sapyta, N. L., Olsen, C. M., & Winder, D. G. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300918 · Cited by 56 · see citing works

Region-Specific Changes in the Subcellular Distribution of AMPA Receptor GluR1 Subunit in the Rat Ventral Tegmental Area after Acute or Chronic Morphine Administration

Lane, D., Lessard, A., Chan, J., Colago, E. E. O., Zhou, Y., Schlussman, S. D., Kreek, M. J., & Pickel, V. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2151-08.2008 · Cited by 56 · see citing works

Spike Timing-Dependent Long-Term Potentiation in Ventral Tegmental Area Dopamine Cells Requires PKC

Luu, P., & Malenka, R. C. (2008) · Journal of Neurophysiology · doi:10.1152/jn.01384.2007 · Cited by 52 · see citing works

Strain Specific Synaptic Modifications on Ventral Tegmental Area Dopamine Neurons After Ethanol Exposure

Wanat, M. J., Sparta, D. R., Hopf, F. W., Bowers, M. S., Melis, M., & Bonci, A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.042 · Cited by 49 · see citing works

Cocaine activates Homer1 immediate early gene transcription in the mesocorticolimbic circuit: Differential regulation by dopamine and glutamate signaling

Ghasemzadeh, M. B., Windham, L. K., LAKE, R. W., Acker, C. J., & Kalivas, P. W. (2008) · Synapse · doi:10.1002/syn.20577 · Cited by 43 · see citing works

NMDA Receptors on Non-Dopaminergic Neurons in the VTA Support Cocaine Sensitization

Luo, Y., Good, C. H., Dı́az-Ruiz, O., Zhang, Y., Hoffman, A. F., Shan, L., Kuang, S. Y., Malik, N., Chefer, V. I., Tomac, A. C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012141 · Cited by 41 · see citing works

Renewed Cocaine Exposure Produces Transient Alterations in Nucleus Accumbens AMPA Receptor-Mediated Behavior

Bachtell, R. K., & Self, D. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2060-08.2008 · Cited by 35 · see citing works

Repeated administration of AMPA or a metabotropic glutamate receptor agonist into the rat ventral tegmental area augments the subsequent behavioral hyperactivity induced by cocaine

Dunn, J. M., Inderwies, B. R., Licata, S. C., & Pierce, R. C. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2054-9 · Cited by 27 · see citing works

Dissecting the neural circuitry of addiction and psychiatric disease with optogenetics

Stuber, G. D. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.102 · Cited by 18 · see citing works

Neurobiology of addiction: a neurocircuitry analysis

Koob, G. F., & Volkow, N. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00104-8 · Cited by 3,698 · see citing works

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

Cohen, J. Y., Haesler, S., Vong, L., Lowell, B. B., & Uchida, N. (2012) · Nature · doi:10.1038/nature10754 · Cited by 1,318 · see citing works

The brain on drugs: from reward to addiction

Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306 · see citing works

Drug addiction: updating actions to habits to compulsions ten years on

Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225 · see citing works

NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).

Luscher, C., & Malenka, R. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005710 · Cited by 1,110 · see citing works

Reward and aversion in a heterogeneous midbrain dopamine system

Lammel, S., Lim, B. K., & Malenka, R. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.019 · Cited by 804 · see citing works

Nociception, pain, negative moods, and behavior selection

Baliki, M. N., & Apkarian, A. V. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.005 · Cited by 731 · see citing works

Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens

Britt, J. P., Benaliouad, F., McDevitt, R. A., Stuber, G. D., Wise, R. A., & Bonci, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.040 · Cited by 716 · see citing works

Optogenetic investigation of neural circuits underlying brain disease in animal models

Tye, K. M., & Deisseroth, K. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3171 · Cited by 745 · see citing works

The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Scofield, M. D., Heinsbroek, J. A., Gipson, C. D., Kupchik, Y. M., Spencer, S., Smith, A. C. W., Roberts-Wolfe, D., & Kalivas, P. W. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012484 · Cited by 598 · see citing works

Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction

Volkow, N. D., Wang, G. J., Fowler, J. S., Tomasi, D., & Baler, R. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_169 · Cited by 525 · see citing works

The dark side of emotion: the addiction perspective

Koob, G. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.044 · Cited by 433 · see citing works

A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward

Stamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., Boyce, F., Mattis, J., Ramakrishnan, C., Deisseroth, K., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.023 · Cited by 364 · see citing works

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

Corkrum, M., Covelo, A., Lines, J., Bellocchio, L., Pisansky, M., Loke, K., Quintana, R., Rothwell, P. E., Lujan, R., Marsicano, G., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.026 · Cited by 327 · see citing works

Oxytocin-dependent reopening of a social reward learning critical period with MDMA

Nardou, R., Lewis, E. M., Rothhaas, R., Xu, R., Yang, A., Boyden, E., & Dölen, G. (2019) · Nature · doi:10.1038/s41586-019-1075-9 · Cited by 334 · see citing works

Common brain mechanisms of chronic pain and addiction

Elman, I., & Borsook, D. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.027 · Cited by 303 · see citing works

Neuronal plasticity and neurotrophic factors in drug responses

Castrén, E., & Antila, H. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.61 · Cited by 284 · see citing works

Addiction as a brain disease revised: why it still matters, and the need for consilience

(2021) · doi:10.1038/s41386-020-00950-y · Cited by 290 · see citing works

Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology

Creed, M., Pascoli, V. J., & Lüscher, C. (2015) · Science · doi:10.1126/science.1260776 · Cited by 280 · see citing works

Reward and aversion

Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253 · see citing works

Dopamine Neurons Control Striatal Cholinergic Neurons via Regionally Heterogeneous Dopamine and Glutamate Signaling

Chuhma, N., Mingote, S., Moore, H., & Rayport, S. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.027 · Cited by 233 · see citing works

A multistep general theory of transition to addiction

Piazza, P. V., & Deroche-Gamonet, V. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3224-4 · Cited by 227 · see citing works

Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment

King, L. B., Walum, H., Inoue, K., Eyrich, N. W., & Young, L. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.008 · Cited by 191 · see citing works

FosB differentially modulates nucleus accumbens direct and indirect pathway function

Grueter, B. A., Robison, A. J., Neve, R. L., Nestler, E. J., & Malenka, R. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221742110 · Cited by 191 · see citing works

Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction

Bhattacherjee, A., Djekidel, M. N., Chen, R., Chen, W., Tuesta, L. M., & Zhang, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-12054-3 · Cited by 174 · see citing works

Role of nucleus accumbens in neuropathic pain: Linked multi-scale evidence in the rat transitioning to neuropathic pain

Chang, P.-C., Pollema-Mays, S. L., Centeno, M. V., Procissi, D., Contini, M., Baria, A. T., Martina, M., & Apkarian, A. V. (2014) · Pain · doi:10.1016/j.pain.2014.02.019 · Cited by 161 · see citing works

Nucleus Accumbens Modulation in Reward and Aversion

Klawonn, A. M., & Malenka, R. C. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037457 · Cited by 163 · see citing works

Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement

Tolu, S., Eddine, R., Marti, F., David, V, Graupner, M., Pons, S., Baudonnat, M., Husson, M., Besson, M., Reperant, C., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.83 · Cited by 151 · see citing works

Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain

Reeves, K. C., Shah, N., Muñoz, B., & Atwood, B. K. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.919773 · Cited by 156 · see citing works

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148 · see citing works

Single-cell RNA-seq uncovers a robust transcriptional response to morphine by glia

Avey, D., Sankararaman, S., Yim, A. K. Y., Barve, R., Milbrandt, J., & Mitra, R. D. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.080 · Cited by 143 · see citing works

Targeting glutamate uptake to treat alcohol use disorders

Rao, P. S. S., Bell, R. L., Engleman, E. A., & Sari, Y. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00144 · Cited by 136 · see citing works

Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources

Beeler, J. A., Frazier, C. R. M., & Zhuang, X. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00049 · Cited by 136 · see citing works

Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity

Graziane, N. M., Polter, A. M., Briand, L. A., Pierce, R. C., & Kauer, J. A. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.034 · Cited by 121 · see citing works

Distinct neural mechanisms for the prosocial and rewarding properties of MDMA

Heifets, B. D., Salgado, J. S., Taylor, M. D., Hoerbelt, P., Cardozo Pinto, D. F., Steinberg, E. E., Walsh, J. J., Sze, J. Y., & Malenka, R. C. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw6435 · Cited by 120 · see citing works

Association of Gamma-Aminobutyric Acid A Receptor α2 Gene (GABRA2) with Alcohol Use Disorder

Li, D., Sulovari, A., Cheng, C., Zhao, H., Kranzler, H. R., & Gelernter, J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.291 · Cited by 103 · see citing works

Dual action of ketamine confines addiction liability

Simmler, L. D., Li, Y., Hadjas, L. C., Hiver, A., van Zessen, R., & Lüscher, C. (2022) · Nature · doi:10.1038/s41586-022-04993-7 · Cited by 95 · see citing works

Mechanisms of transgenerational inheritance of addictive-like behaviors

Vassoler, F. M., & Sadri-Vakili, G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.064 · Cited by 96 · see citing works

Endocannabinoid-mediated synaptic plasticity and addiction-related behavior

Sidhpura, N., & Parsons, L. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.034 · Cited by 92 · see citing works

Illuminating circuitry relevant to psychiatric disorders with optogenetics

Steinberg, E. E., Christoffel, D. J., Deisseroth, K., & Malenka, R. C. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.004 · Cited by 92 · see citing works

Illicit dopamine transients: reconciling actions of abused drugs

Covey, D. P., Roitman, M. F., & Garris, P. A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.02.002 · Cited by 90 · see citing works

Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

Goldberg, L. R., & Gould, T. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14060 · Cited by 88 · see citing works

Erratum: MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption

Darcq, E., Warnault, V, Phamluong, K., Besserer, G. M., Liu, F., & Ron, D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.155 · Cited by 87 · see citing works

Early adverse experience and substance addiction: Dopamine, oxytocin, and glucocorticoid pathways

Kim, S., Kwok, S., Mayes, L. C., Potenza, M. N., Rutherford, H. J. V., & Strathearn, L. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13140 · Cited by 85 · see citing works

Reduced d-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity

Curcio, L., Podda, M. V., Leone, L., Piacentini, R., Mastrodonato, A., Cappelletti, P., Sacchi, S., Pollegioni, L., Grassi, C., & D’Ascenzo, M. (2013) · Brain · doi:10.1093/brain/awt036 · Cited by 79 · see citing works

Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol: Abstinence across drugs

Becker, J. A. J., Kieffer, B. L., & Le Merrer, J. (2017) · Addiction Biology · doi:10.1111/adb.12405 · Cited by 77 · see citing works

Dopamine Circuit Mechanisms of Addiction-Like Behaviors

Poisson, C. L., Engel, L., & Saunders, B. T. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.752420 · Cited by 75 · see citing works

Opioid-induced fragile-like regulatory T cells contribute to withdrawal

Zhu, Y., Yan, P., Wang, R., Lai, J., Tang, H., Xiao, X., Yu, R., Bao, X., Zhu, F., Wang, K., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.030 · Cited by 73 · see citing works

Stress and cocaine trigger divergent and cell type-specific regulation of synaptic transmission at single spines in nucleus accumbens

Khibnik, L. A., Beaumont, M., Doyle, M., Heshmati, M., Slesinger, P. A., Nestler, E. J., & Russo, S. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.022 · Cited by 67 · see citing works

Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine

Huang, W., Placzek, A. N., Viana Di Prisco, G., Khatiwada, S., Sidrauski, C., Krnjević, K., Walter, P., Dani, J. A., & Costa-Mattioli, M. (2016) · eLife · doi:10.7554/elife.12052 · Cited by 64 · see citing works

Cortico-striatal circuits: novel therapeutic targets for substance use disorders

Kravitz, A. V., Tomasi, D., LeBlanc, K. H., Baler, R., Volkow, N. D., Bonci, A., & Ferré, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.048 · Cited by 63 · see citing works

Age-dependent Effects of Tobacco Smoke and Nicotine on Cognition and the Brain: A Systematic Review of the Human and Animal Literature Comparing Adolescents and Adults.

Colyer-Patel, K., Kuhns, L., Weidema, A., Lesscher, H., & Cousijn, J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105038 · Cited by 54 · see citing works

Closing the Gate in the Limbic Striatum: Prefrontal Suppression of Hippocampal and Thalamic Inputs

Calhoon, G. G., & O’Donnell, P. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.032 · Cited by 50 · see citing works

Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability

Klug, J. R., Mathur, B. N., Kash, T. L., Wang, H.-D., Matthews, R. T., Robison, A. J., Anderson, M. E., Deutch, A. Y., Lovinger, D. M., Colbran, R. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045323 · Cited by 49 · see citing works

Memory, plasticity and sleep - A role for calcium permeable AMPA receptors?

Shepherd, J. D. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00049 · Cited by 49 · see citing works

NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward

Logan, R. W., Parekh, P. K., Kaplan, G. N., Becker-Krail, D. D., Williams, W. P., Yamaguchi, S., Yoshino, J., Shelton, M. A., Zhu, X., Zhang, H., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0061-1 · Cited by 48 · see citing works

Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania

Parekh, P. K., Becker-Krail, D., Sundaravelu, P., Ishigaki, S., Okado, H., Sobue, G., Huang, Y., & McClung, C. A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.022 · Cited by 48 · see citing works

Cocaine addiction as a homeostatic reinforcement learning disorder.

Keramati, M., Durand, A., Girardeau, P., Gutkin, B., & Ahmed, S. H. (2017) · Psychological Review · doi:10.1037/rev0000046 · Cited by 44 · see citing works

Between the primate and 'reptilian' brain: rodent models demonstrate the role of corticostriatal circuits in decision making

Lee, A. M., Tai, L.-H., Zador, A., & Wilbrecht, L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.042 · Cited by 37 · see citing works

Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway

Yohn, S. E., Galbraith, J., Calipari, E. S., & Conn, P. J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00601 · Cited by 36 · see citing works

Tapering opioids: a comprehensive qualitative review

Davis, M. P., Digwood, G., Mehta, Z., & McPherson, M. L. (2020) · Annals of Palliative Medicine · doi:10.21037/apm.2019.12.10 · Cited by 33 · see citing works

d-Serine in the nucleus accumbens region modulates behavioral sensitization and extinction of conditioned place preference

Liu, Z.-Q., Gu, X.-H., Yang, Y.-J., Yin, X.-P., Xu, L.-J., & Wang, W. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.02.002 · Cited by 23 · see citing works

Ethanol Modulates Glutamatergic Transmission and NMDAR-Mediated Synaptic Plasticity in the Agranular Insular Cortex

Shillinglaw, J. E., Morrisett, R. A., & Mangieri, R. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01458 · Cited by 21 · see citing works

Morphine-induced inhibition of Ca²⁺ -dependent <scp>d</scp> -serine release from astrocytes suppresses excitability of GABAergic neurons in the nucleus accumbens: <scp>d</scp> -serine in morphine addiction

Wu, J., Zhao, R., Guo, L., & Zhen, X. (2017) · Addiction Biology · doi:10.1111/adb.12417 · Cited by 21 · see citing works

Plasticity determined by indentation and theoretical plasticity of materials

Milman, Y. V., Chugunova, S. I., & Goncharova, І. V. (2009) · Bulletin of the Russian Academy of Sciences Physics · doi:10.3103/s1062873809090093 · Cited by 12 · see citing works

The Study of Measuring Clay plasticity and Forecasting of Nud Plasticity

Sun, J., & Wen-li, Z. (2007)

Plasticity of Clays (Die Plastizitaet der Tone)

Atterberg, A. (1974)

Determination of New Plasticity Characteristic of Alloys at Mechanical Compression and Tensile Tests and the Influence of Structural Factors on Plasticity

Milman, Y. V., Galanov, B. A., Goncharuk, V. A., et al. (2022) · Diffusion and defect data, solid state data. Part B, Solid state phenomena/Solid state phenomena · doi:10.4028/p-43wx05 · Cited by 1 · see citing works

One-dimensional plasticity

Anand, L., & Govindjee, S. (2020) · doi:10.1093/oso/9780198864721.003.0020