The DOI matches its Crossref record.
The ACAT inhibitor CP‐113,818 markedly reduces amyloid pathology in a Mouse Model of Alzheimer's disease
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ACAT1 inhibition reduces multiple aspects of AD pathology in vivo and in vitro.
“ACAT1 inhibition reduces multiple aspects of AD pathology in vivo 12 and in vitro. 13”
From Inhibition of Acyl‐CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low‐density lipoprotein receptor 1 (LRP1)‐dependent phagocytosis of amyloid beta protein in microglia (2025) · cites this paper as [12]
Citation 12 is attached to the in vivo portion of the sentence, not the in vitro portion. The indexed copy is an erratum (p. 1014) whose title identifies reduced amyloid pathology in a mouse model, and its correction discusses plaque counts without changing the original conclusions. It does not provide results establishing reductions in multiple aspects of AD pathology. (LLM, conf=0.76)
Experimental — accuracy not yet measuredACAT1 inhibition reduces Aβ pathology in AD models.
“Inhibiting ACAT1 has been shown to reduce amyloid beta (Aβ) pathology, though the mechanism is unclear.”
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Citations
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Sorted by citations
Lefterov, I., Bookout, A., Wang, Z., Staufenbiel, M., Mangelsdorf, D., & Koldamova, R. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-20 · Cited by 89
Hovde, M. J., Maaser‐Hecker, A., Bae, J., & Tanzi, R. E. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70879 · Cited by 8
Metadata
- Authors
- Hutter-Paier, B., Huttunen, H. J., Puglielli, L., Eckman, C. B., Kim, D. Y., Hofmeister, A., Moir, R. D., Domnitz, S. B., Frosch, M. P., Windisch, M., & Kovacs, D. M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 68
- Issue
- 5
- Pages
- 1014
- ISSN
- 0896-6273
- Cited by
- 5
- References
- 0
- Language
- en
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