The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Role of ACh-GABA Cotransmission in Detecting Image Motion and Motion Direction
Open accessAbstract
Starburst amacrine cells (SACs) process complex visual signals in the retina using both acetylcholine (ACh) and gamma-aminobutyric acid (GABA), but the synaptic organization and function of ACh-GABA corelease remain unclear. Here, we show that SACs make cholinergic synapses onto On-Off direction-selective ganglion cells (DSGCs) from all directions but make GABAergic synapses onto DSGCs only from the null direction. ACh and GABA were released differentially in a Ca(2+) level-specific manner, suggesting the two transmitters were released from different vesicle populations. Despite the symmetric cholinergic connection, the light-evoked cholinergic input to a DSGC, detected at both light onset and offset, was motion- and direction-sensitive. This input was facilitated by two-spot apparent motion in the preferred direction but supressed in the null direction, presumably by a GABAergic mechanism. The results revealed a high level of synaptic intricacy in the starburst circuit and suggested differential, yet synergistic, roles of ACh-GABA cotransmission in motion sensitivity and direction selectivity.
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“More recently, an elegant study employing paired recordings from neighboring retinal neurons demonstrated monosynaptic transmission of both Ach and GABA from SACs to direction-sensitive retinal ganglion cells (DSGCs).86”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [86]
In the citing paper
“Ach and GABA release are differentially sensitive to calcium concentration and calcium channel antagonists, suggesting separate vesicle populations.86”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [86]
In the citing paper
“Release of GABA from SACs is restricted to the dendrites of the postsynaptic DSGCs' null direction, whereas release of Ach is not spatially restricted.”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [86]
In the citing paper
“These studies suggest that Ach and GABA are segregated into different synaptic vesicles and/or axonal boutons to endow single SACs with spatial selectivity over cotransmission of neurotransmitters.”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [86]
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Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Corelease of Two Fast Neurotransmitters at a Central Synapse
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Directionally selective calcium signals in dendrites of starburst amacrine cells
Euler, T., Detwiler, P. B., & Denk, W. T. (2002) · Nature · doi:10.1038/nature00931 · Cited by 588
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Short-term plasticity at the calyx of held
von Gersdorff, H., & Borst, J. G. G. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn705 · Cited by 388
The shape and arrangement of the cholinergic neurons in the rabbit retina
Tauchi, M., & Masland, R. H. (1984) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1984.0085 · Cited by 385
A shared vesicular carrier allows synaptic corelease of GABA and glycine
Wojcik, S. M., Katsurabayashi, S., Guillemin, I., Friauf, E., Rosenmund, C., Brose, N., & Rhee, J.-S. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.016 · Cited by 374
Chapter 2 The mosaic of amacrine cells in the mammalian retina
Vaney, D. I. (1990) · Progress in Retinal Research · doi:10.1016/0278-4327(90)90004-2 · Cited by 372
Mechanisms and circuitry underlying directional selectivity in the retina
Fried, S. I., Münch, T. A., & Werblin, F. S. (2002) · Nature · doi:10.1038/nature01179 · Cited by 368
Yoshida, K., Watanabe, D., Ishikane, H., Tachibana, M., Pastan, I. H., & Nakanishi, S. (2001) · Neuron · doi:10.1016/s0896-6273(01)00316-6 · Cited by 363
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Wiring specificity in the direction-selectivity circuit of the retina
Briggman, K. L., Helmstaedter, M., & Denk, W. (2011) · Nature · doi:10.1038/nature09818 · Cited by 883
Kay, J. N., la Huerta, I. D., Kim, I.-J., Zhang, Y., Yamagata, M., Chu, M. W., Meister, M., & Sanes, J. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0907-11.2011 · Cited by 351
Direction selectivity in the retina: symmetry and asymmetry in structure and function
Vaney, D. I., Sivyer, B., & Taylor, W. R. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3165 · Cited by 330
Neurotransmitter Corelease: Mechanism and Physiological Role
Hnasko, T. S., & Edwards, R. H. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153315 · Cited by 284
Seeing Things in Motion: Models, Circuits, and Mechanisms
Borst, A., & Euler, T. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.031 · Cited by 291
Metadata
- Authors
- Lee, S., Kim, K., & Zhou, Z. J.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Yale University (US)
- Corresponding author
- Zhou, Z. Jimmy
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 68
- Issue
- 6
- Pages
- 1159-1172
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3094727
- OpenAlex
- W1991368688
- Cited by
- 241
- References
- 68
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 25 · 2023: 22 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 11 · 2018: 14 · 2017: 17 · 2016: 23 · 2015: 15 · 2014: 14 · 2013: 14 · 2012: 15
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Research to Prevent Blindness
- National Institutes of Health
- National Eye Institute (R01 EY10894, R01EY010894, P30EY000785, R01EY017353)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Keywords
- acetylcholine, GABA, co-transmission, starburst amacrine cells, direction-selective ganglion cells, motion detection, direction selectivity, cholinergic synapses, GABAergic synapses, calcium-dependent neurotransmitter release, retinal circuitry
- MeSH terms
- Acetylcholine, Animals, gamma-Aminobutyric Acid, Motion Perception, Synaptic Transmission, Photic Stimulation, Rabbits, Retina, Synapses, Amacrine Cells
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