Cited by 241Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanismsRetinal Development and Disorders

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Role of ACh-GABA Cotransmission in Detecting Image Motion and Motion Direction

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Lee, Seunghoon, Kim, Kyongmin, Zhou, Z. Jimmy·2010·Neuron

DOI 10.1016/j.neuron.2010.11.031PMC PMC3094727

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Abstract

Starburst amacrine cells (SACs) process complex visual signals in the retina using both acetylcholine (ACh) and gamma-aminobutyric acid (GABA), but the synaptic organization and function of ACh-GABA corelease remain unclear. Here, we show that SACs make cholinergic synapses onto On-Off direction-selective ganglion cells (DSGCs) from all directions but make GABAergic synapses onto DSGCs only from the null direction. ACh and GABA were released differentially in a Ca(2+) level-specific manner, suggesting the two transmitters were released from different vesicle populations. Despite the symmetric cholinergic connection, the light-evoked cholinergic input to a DSGC, detected at both light onset and offset, was motion- and direction-sensitive. This input was facilitated by two-spot apparent motion in the preferred direction but supressed in the null direction, presumably by a GABAergic mechanism. The results revealed a high level of synaptic intricacy in the starburst circuit and suggested differential, yet synergistic, roles of ACh-GABA cotransmission in motion sensitivity and direction selectivity.

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Authors: Lee, S., Kim, K., & Zhou, Z. J.
Affiliations: University of Arkansas for Medical Sciences (US)
Yale University (US)
Corresponding author: Zhou, Z. Jimmy
ORCID: Kim, Kyongmin
Zhou, Z. Jimmy
Venue: Neuron
Publisher: Elsevier BV
Published: 2010-12
Volume: 68
Issue: 6
Pages: 1159-1172
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2010.11.031
PMC: PMC3094727
OpenAlex: W1991368688
Cited by: 241
References: 68
Citations by year: 2026: 12 · 2025: 9 · 2024: 25 · 2023: 22 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 11 · 2018: 14 · 2017: 17 · 2016: 23 · 2015: 15 · 2014: 14 · 2013: 14 · 2012: 15
FWCI: 5.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 959 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Research to Prevent Blindness
National Institutes of Health
National Eye Institute (R01 EY10894, R01EY010894, P30EY000785, R01EY017353)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords: acetylcholine, GABA, co-transmission, starburst amacrine cells, direction-selective ganglion cells, motion detection, direction selectivity, cholinergic synapses, GABAergic synapses, calcium-dependent neurotransmitter release, retinal circuitry
MeSH terms: Acetylcholine, Animals, gamma-Aminobutyric Acid, Motion Perception, Synaptic Transmission, Photic Stimulation, Rabbits, Retina, Synapses, Amacrine Cells

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Role of ACh-GABA Cotransmission in Detecting Image Motion and Motion Direction

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