Enhancement of Dorsal Hippocampal Activity by Knockdown of HCN1 Channels Leads to Anxiolytic- and Antidepressant-like Behaviors
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Items 101–159 of 159
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- Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8bYe Sun Han, Kyle A. Lyman, Matt Clutter, Gary E. Schiltz, Quratul-Ain Ismail, Xiangying Cheng, Chi-Hao Luan, Dane M. Chetkovich · 2016 · Journal of Visualized Experiments
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- Downregulation of the HCN1 Channel Alleviates Anxiety- and Depression-Like Behaviors in Mice With Cerebral Ischemia-Reperfusion Injury by Suppressing the NLRP3 InflammasomeZhou, Mei, Tao, Xiaoqin, Lin, Kuan, Leng, Changlong, Yang, Youhua, Gui, Yuran, Sun, Yaojian, Zhou, Meiling, Sun, Binlian, Xia, Yiyuan et al. · 2025 · Journal of the American Heart Association
- Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotypeTeichman, Emily M., Hu, Jianping, Lin, Hsiao-yun, Fisher-Foye, Rachel L., Blando, Anthony, Hu, Xiaoping, Kaniskan, H. Ümit, Montgomery, Sarah E., Cai, Min, Parise, Lyonna F. et al. · 2025 · Molecular Psychiatry
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- Chronic Cerebral Hypoperfusion-induced Dysregulations of Hyperpolarization- activated Cyclic Nucleotide-gated, KCNQ and G Protein-coupled Inwardly Rectifying Potassium Channels Correlated with Susceptibility and Unsusceptibility to Anxiety BehaviorsPan Luo, Wei Da Liu, Mei Ling Zhou, Youwei Li, Kuan Lin · 2022 · Current Neurovascular Research
- Structural mechanism of human HCN1 hyperpolarization-activated channel inhibition by ivabradineTong Che, Wei Zhang, Xinyu Cheng, Sijia Lv, Minqing Zhang, Yuting Zhang, Tingting Yang, Weiwei Nan, Shuangyan Wan, Bo Zeng et al. · 2024 · Journal of Biological Chemistry
- Anti-nociceptive and anxiolytic effects of systemic flupirtine and its direct inhibitory actions on in vivo neuronal mechanical sensory responses in the adult rat anterior cingulate cortexYu Matsumoto, Yuji Fujino, Hidemasa Furue · 2020 · Biochemical and Biophysical Research Communications
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- The Role of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in the Pathophysiology of Absence EpilepsyMelis Yavuz · 2018 · Journal of the Turkish Epilepsi Society
- Identification of HCN1 as a 14-3-3 clientColten K. Lankford, Jon C. D. Houtman, Sheila A. Baker · 2022 · PLoS ONE
- The Effect of SIRT3/Ac-SOD2 Mediated Oxidative Stress and HCN1 Channel Activity on Anesthesia/Surgery Induced Anxiety-Like Behavior in MiceHuihui Miao, Qiang Liu, Ning Wang, Yanping Liu, Chen Chen, Hai‐Bi Wang, Hui Huang, Wei-Feng Wu, Jia-Tao Lin, Yongkang Qiu et al. · 2022 · Frontiers in Medicine
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- Antidepressant and anxiolytic-like activities of the dichloromethane/methanol extract of Crateva adansonii in mice exposed to chronic mild stressGalba Jean Beppe, Nanou Gael Allah-Doum, Bertrand Mpoo Barga, Alice Irène Folefack, Alain Bertrand Dongmo · 2023 · Notulae Scientia Biologicae
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- Ketamine Reverses Depressive-Like Behavior Induced by Optogenetic Stimulation of Glutamatergic Neurons in the Dorsal HippocampusUliana S. Drozd, Ekaterina V. Sukhareva, Veta V. Bulygina, Tatyana S. Kalinina, Н. Н. Дыгало, Dmitriy A. Lanshakov · 2025 · Neurochemical Journal
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- Clonidine Ameliorates Anxiety-Like Behavior via GRIN2B Demethylation and NR2B Activation in a Two-Vessel Occlusion Rat ModelKe Wang, Wenxin Zhang, Qing Wang, Gang Li, Yue Chen, Zhi He · 2026 · Research Square